{"id":"https://openalex.org/W2024607222","doi":"https://doi.org/10.3109/02841869209088291","title":"Normal Tissue Reactions in Mice after Combined Treatment with Metoclopramide and Ionizing Radiation","display_name":"Normal Tissue Reactions in Mice after Combined Treatment with Metoclopramide and Ionizing Radiation","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2024607222","doi":"https://doi.org/10.3109/02841869209088291","mag":"2024607222","pmid":"https://pubmed.ncbi.nlm.nih.gov/1632984"},"language":"en","primary_location":{"id":"doi:10.3109/02841869209088291","doi":"https://doi.org/10.3109/02841869209088291","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841869209088291","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869209088291?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869209088291?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049920110","display_name":"Stein Lybak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stein Lybak","raw_affiliation_strings":["Department of Oto-rhino-laryngology, University Hospital of Lund, Sweden","Department of Molecular Ecogenetics, University Hospital of Lund, Sweden","Department of Oncology, University Hospital of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-rhino-laryngology, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Molecular Ecogenetics, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Oncology, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088127482","display_name":"Elisabeth Kjell\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elisabeth Kjellen","raw_affiliation_strings":["Department of Oncology, University Hospital of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026199499","display_name":"Per Gunnar Nilsson","orcid":"https://orcid.org/0000-0002-7983-9778","observed_orcids":["https://orcid.org/0000-0002-7983-9778"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Nilsson","raw_affiliation_strings":["Department of Radiation Physics, University Hospital of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Physics, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008368610","display_name":"A Tomaszewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andrejs Tomaszewicz","raw_affiliation_strings":["Department of Radiation Physics, University Hospital of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Physics, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103277461","display_name":"Johan P. Wennerberg","orcid":"https://orcid.org/0000-0002-5336-4014","observed_orcids":["https://orcid.org/0000-0002-5336-4014"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Wennerberg","raw_affiliation_strings":["Department of Oto-rhino-laryngology, University Hospital of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oto-rhino-laryngology, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112072836","display_name":"Ronald W. Pero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ronald W. Pero","raw_affiliation_strings":["Department of Molecular Ecogenetics, University Hospital of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Ecogenetics, University Hospital of Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7159,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83680021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"4","first_page":"469","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.15760000050067902,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":1.0},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.7639999985694885},{"id":"https://openalex.org/keywords/normal-tissue-toxicity","display_name":"normal tissue toxicity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8550000190734863},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dose-scheduling","display_name":"dose scheduling","score":0.746999979019165},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.6639999747276306},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.41200000047683716},{"id":"https://openalex.org/keywords/129-mice","display_name":"129 mice","score":0.6919999718666077},{"id":"https://openalex.org/keywords/balb-c-nude-mice","display_name":"BALB/c nude mice","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2778479196","wikidata":"https://www.wikidata.org/wiki/Q421095","display_name":"Metoclopramide","level":3,"score":0.9713771939277649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7551147937774658},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6958390474319458},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6080857515335083},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5601121187210083},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5012106895446777},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4782899022102356},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4241238236427307},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.3625675439834595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34837818145751953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10031938552856445},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008787","descriptor_name":"Metoclopramide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008787","descriptor_name":"Metoclopramide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/02841869209088291","doi":"https://doi.org/10.3109/02841869209088291","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841869209088291","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869209088291?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},{"id":"pmid:1632984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oncologica (Stockholm, Sweden)","raw_type":"Journal Article"},{"id":"pmh:oai:lup.lub.lu.se:c719a65d-9127-4c4b-b479-51d7b6457a32","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1106375","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1651-226X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3109/02841869209088291","doi":"https://doi.org/10.3109/02841869209088291","is_oa":true,"landing_page_url":"https://doi.org/10.3109/02841869209088291","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/02841869209088291?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024607222.pdf","grobid_xml":"https://content.openalex.org/works/W2024607222.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W159690873","https://openalex.org/W1966934669","https://openalex.org/W1975470610","https://openalex.org/W1979855134","https://openalex.org/W1984568013","https://openalex.org/W1995241334","https://openalex.org/W2020372336","https://openalex.org/W2025080283","https://openalex.org/W2025392650","https://openalex.org/W2044689050","https://openalex.org/W2059250970","https://openalex.org/W2060251624","https://openalex.org/W2064336212","https://openalex.org/W2073053104","https://openalex.org/W2086389710","https://openalex.org/W2086586925","https://openalex.org/W2086637334","https://openalex.org/W2088274783","https://openalex.org/W2108669634","https://openalex.org/W2128243528","https://openalex.org/W2162515678","https://openalex.org/W2163342607","https://openalex.org/W2164832682","https://openalex.org/W2258039169","https://openalex.org/W4238480726"],"related_works":["https://openalex.org/W2128243528","https://openalex.org/W2035022677","https://openalex.org/W2056954726","https://openalex.org/W2080170849","https://openalex.org/W1996234301","https://openalex.org/W2071376994","https://openalex.org/W1910786419","https://openalex.org/W41076772","https://openalex.org/W2912943142","https://openalex.org/W2050333620"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"shown":[3,49],"that":[4],"metoclopramide":[5,39,47,74,97,157],"potentiates":[6],"the":[7,21,31,35,56,101,135],"effect":[8,58,68],"of":[9,15,38,59,69,125,144,146],"ionizing":[10],"radiation":[11,43,60,70,89,147],"and":[12,23,46,96],"cisplatin":[13],"treatment":[14],"human":[16],"squamous":[17],"cell":[18],"carcinomas":[19],"from":[20],"head":[22],"neck":[24],"region":[25],"xenografted":[26],"to":[27,50,88,133,149],"nude":[28],"mice.":[29],"In":[30],"present":[32],"tumor":[33],"study,":[34],"dose":[36],"scheduling":[37],"in":[40,54,71,81,93,105,107,117,137,139,152],"combination":[41,72],"with":[42,73],"was":[44,48,78,115,130],"evaluated,":[45],"be":[51],"most":[52],"effective":[53],"potentiating":[55],"cytotoxic":[57],"when":[61],"administered":[62],"one":[63],"hour":[64],"before":[65],"radiation.":[66],"The":[67,142],"on":[75],"normal":[76,150],"tissue":[77,151],"also":[79],"studied":[80,92,116],"two":[82],"well-established":[83],"models.":[84],"Acute":[85],"skin":[86,103],"reactions":[87],"exposure":[90],"were":[91],"129-type":[94],"mice,":[95],"did":[98],"not":[99,131],"enhance":[100],"acute":[102],"reaction":[104],"this":[106,138],"vivo":[108,140],"model.":[109,141],"Survival":[110],"after":[111],"whole":[112],"body":[113],"irradiation":[114],"heterozygote":[118],"Balb/c":[119],"nu/+":[120],"mice":[121],"as":[122],"a":[123],"measure":[124],"bone":[126],"marrow":[127],"toxicity.":[128],"Metoclopramide":[129],"found":[132],"affect":[134],"LD50/30":[136],"absence":[143],"potentiation":[145],"damage":[148],"these":[153],"animal":[154],"studies,":[155],"makes":[156],"an":[158],"interesting":[159],"possibility":[160],"for":[161],"future":[162],"clinical":[163],"evaluation.":[164]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}