{"id":"https://openalex.org/W2024465865","doi":"https://doi.org/10.2131/jts.37.899","title":"Effects of butane-2,3-dione thiosemicarbazone oxime on testicular damage induced by cadmium in mice","display_name":"Effects of butane-2,3-dione thiosemicarbazone oxime on testicular damage induced by cadmium in mice","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2024465865","doi":"https://doi.org/10.2131/jts.37.899","mag":"2024465865","pmid":"https://pubmed.ncbi.nlm.nih.gov/23038000"},"language":"en","primary_location":{"id":"doi:10.2131/jts.37.899","doi":"https://doi.org/10.2131/jts.37.899","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.37.899","pdf_url":"https://www.jstage.jst.go.jp/article/jts/37/5/37_899/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jts/37/5/37_899/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062056990","display_name":"Mayara L\u00fctchemeyer de Freitas","orcid":"https://orcid.org/0000-0002-9977-4406","observed_orcids":["https://orcid.org/0000-0002-9977-4406"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mayara Lutchemeyer de Freitas","raw_affiliation_strings":["Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010755638","display_name":"La\u00edza Dalmolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"La\u00edza Dalmolin","raw_affiliation_strings":["Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087622678","display_name":"Lia Pavelacki Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lia Pavelacki Oliveira","raw_affiliation_strings":["Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034178270","display_name":"La\u00eds da Rosa Moreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"La\u00eds da Rosa Moreira","raw_affiliation_strings":["Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026470426","display_name":"Silvane Souza Roman","orcid":"https://orcid.org/0000-0002-7769-9759","observed_orcids":["https://orcid.org/0000-0002-7769-9759"]},"institutions":[{"id":"https://openalex.org/I4210149719","display_name":"Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es","ror":"https://ror.org/05bnh4739","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210149719"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvane Souza Roman","raw_affiliation_strings":["Departamento de Ci\u00eancias da Sa\u00fade, Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es,Campus de Erechim, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias da Sa\u00fade, Universidade Regional Integrada do Alto Uruguai e das Miss\u00f5es,Campus de Erechim, Brazil","institution_ids":["https://openalex.org/I4210149719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025576109","display_name":"F\u00e9lix Alexandre Antunes Soares","orcid":"https://orcid.org/0000-0002-6453-7902","observed_orcids":["https://orcid.org/0000-0002-6453-7902","https://orcid.org/0000-0002-7541-7295"]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F\u00e9lix Alexandre Antunes Soares","raw_affiliation_strings":["Departamento de Qu\u00edmica, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria,Campus UFSM, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica, Centro de Ci\u00eancias Naturais e Exatas, Universidade Federal de Santa Maria,Campus UFSM, Brazil","institution_ids":["https://openalex.org/I33501960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036928361","display_name":"Leandro Bresolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leandro Bresolin","raw_affiliation_strings":["Departamento de Qu\u00edmica, Funda\u00e7\u00e3o Universidade de Rio Grande, Campus Carreiros, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica, Funda\u00e7\u00e3o Universidade de Rio Grande, Campus Carreiros, Brazil","institution_ids":["https://openalex.org/I126460647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103045391","display_name":"Marta Maria Medeiros Frescura Duarte","orcid":"https://orcid.org/0000-0003-4371-4989","observed_orcids":["https://orcid.org/0000-0003-4371-4989"]},"institutions":[{"id":"https://openalex.org/I51882195","display_name":"Universidade Luterana do Brasil","ror":"https://ror.org/00kde4z41","country_code":"BR","type":"education","lineage":["https://openalex.org/I51882195"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marta Maria Medeiros Frescura Duarte","raw_affiliation_strings":["Departamento de Ci\u00eancias da Sa\u00fade, Universidade Luterana do Brasil, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias da Sa\u00fade, Universidade Luterana do Brasil, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I51882195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111786556","display_name":"Ricardo Brand\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33501960","display_name":"Universidade Federal de Santa Maria","ror":"https://ror.org/01b78mz79","country_code":"BR","type":"education","lineage":["https://openalex.org/I33501960"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo Brand\u00e3o","raw_affiliation_strings":["Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Centro de Ci\u00eancias da Sa\u00fade, Universidade Federal de Santa Maria, Campus UFSM, Brazil","institution_ids":["https://openalex.org/I33501960"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.601,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.63213811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"5","first_page":"899","last_page":"910"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium-chloride","display_name":"cadmium chloride","score":0.8309999704360962},{"id":"https://openalex.org/keywords/testicular-injury","display_name":"testicular damage","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cadmium-toxicity","display_name":"cadmium toxicity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7120000123977661},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6769999861717224},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.7279999852180481},{"id":"https://openalex.org/keywords/delta-aminolevulinic-acid-dehydratase","display_name":"delta-aminolevulinic acid dehydratase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/non-protein-thiols","display_name":"non-protein thiols","score":0.6880000233650208},{"id":"https://openalex.org/keywords/testicular-histopathology","display_name":"testicular histopathology","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.8589380383491516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7984973788261414},{"id":"https://openalex.org/C2779648554","wikidata":"https://www.wikidata.org/wiki/Q182738","display_name":"Oxime","level":2,"score":0.6781063079833984},{"id":"https://openalex.org/C56673219","wikidata":"https://www.wikidata.org/wiki/Q2632337","display_name":"NPSH","level":4,"score":0.6734501123428345},{"id":"https://openalex.org/C2778643788","wikidata":"https://www.wikidata.org/wiki/Q411840","display_name":"Cadmium chloride","level":3,"score":0.5240780711174011},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48350146412849426},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.4672776460647583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4291716516017914},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41024279594421387},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4007033407688141},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3747352957725525},{"id":"https://openalex.org/C544657597","wikidata":"https://www.wikidata.org/wiki/Q1091","display_name":"Cadmium","level":2,"score":0.3639943301677704},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.35847213864326477},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.33132994174957275},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13214018940925598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12297987937927246},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08254790306091309}],"mesh":[{"descriptor_ui":"D000623","descriptor_name":"Porphobilinogen Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013733","descriptor_name":"Testicular Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013733","descriptor_name":"Testicular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013733","descriptor_name":"Testicular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013733","descriptor_name":"Testicular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013882","descriptor_name":"Thiosemicarbazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013882","descriptor_name":"Thiosemicarbazones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2131/jts.37.899","doi":"https://doi.org/10.2131/jts.37.899","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.37.899","pdf_url":"https://www.jstage.jst.go.jp/article/jts/37/5/37_899/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:23038000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23038000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of toxicological sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2131/jts.37.899","doi":"https://doi.org/10.2131/jts.37.899","is_oa":true,"landing_page_url":"https://doi.org/10.2131/jts.37.899","pdf_url":"https://www.jstage.jst.go.jp/article/jts/37/5/37_899/_pdf","source":{"id":"https://openalex.org/S148595626","display_name":"The Journal of Toxicological Sciences","issn_l":"0388-1350","issn":["0388-1350","1880-3989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322697822","host_organization_name":"Japanese Society of Toxicological Sciences","host_organization_lineage":["https://openalex.org/P4322697822"],"host_organization_lineage_names":["Japanese Society of Toxicological Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1568588350","display_name":null,"funder_award_id":"01.06.0842-00","funder_id":"https://openalex.org/F4320322502","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul"},{"id":"https://openalex.org/G2495279202","display_name":null,"funder_award_id":"01.06.0842-00","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G335965535","display_name":null,"funder_award_id":"01.06.0842\u201000","funder_id":"https://openalex.org/F4320322904","funder_display_name":"Financiadora de Estudos e Projetos"},{"id":"https://openalex.org/G5453541169","display_name":null,"funder_award_id":"01.06.0842-00","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322502","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","ror":"https://ror.org/05k49za97"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"},{"id":"https://openalex.org/F4320332390","display_name":"Federal Aviation Administration","ror":"https://ror.org/05q0y0j38"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024465865.pdf","grobid_xml":"https://content.openalex.org/works/W2024465865.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W129370812","https://openalex.org/W182540526","https://openalex.org/W1122013619","https://openalex.org/W1563378268","https://openalex.org/W1581414347","https://openalex.org/W1965834241","https://openalex.org/W1972646235","https://openalex.org/W1973624081","https://openalex.org/W1975220274","https://openalex.org/W1983066436","https://openalex.org/W1983310681","https://openalex.org/W1984571847","https://openalex.org/W1986752439","https://openalex.org/W1988397659","https://openalex.org/W1989953524","https://openalex.org/W1990229605","https://openalex.org/W1991535520","https://openalex.org/W1991626506","https://openalex.org/W1993112159","https://openalex.org/W1993747925","https://openalex.org/W1996960515","https://openalex.org/W1997656957","https://openalex.org/W1999180950","https://openalex.org/W1999292652","https://openalex.org/W2003051737","https://openalex.org/W2003490882","https://openalex.org/W2006370393","https://openalex.org/W2007235707","https://openalex.org/W2009414893","https://openalex.org/W2010820975","https://openalex.org/W2016537201","https://openalex.org/W2018994512","https://openalex.org/W2024432240","https://openalex.org/W2031623505","https://openalex.org/W2035554117","https://openalex.org/W2036301368","https://openalex.org/W2038600241","https://openalex.org/W2041750631","https://openalex.org/W2042868758","https://openalex.org/W2044213031","https://openalex.org/W2049407206","https://openalex.org/W2049730127","https://openalex.org/W2057426634","https://openalex.org/W2058409230","https://openalex.org/W2059336697","https://openalex.org/W2059829735","https://openalex.org/W2060169326","https://openalex.org/W2060330834","https://openalex.org/W2061643619","https://openalex.org/W2069139836","https://openalex.org/W2069171960","https://openalex.org/W2071764352","https://openalex.org/W2071829959","https://openalex.org/W2072080603","https://openalex.org/W2075214517","https://openalex.org/W2075635449","https://openalex.org/W2077240758","https://openalex.org/W2081745487","https://openalex.org/W2082863092","https://openalex.org/W2085951179","https://openalex.org/W2089636719","https://openalex.org/W2105090342","https://openalex.org/W2108791332","https://openalex.org/W2115158780","https://openalex.org/W2127895812","https://openalex.org/W2128635872","https://openalex.org/W2131764123","https://openalex.org/W2147769323","https://openalex.org/W2151093371","https://openalex.org/W2165179719","https://openalex.org/W2170481593","https://openalex.org/W2258951291","https://openalex.org/W2397016505","https://openalex.org/W2400418602","https://openalex.org/W2463805562","https://openalex.org/W2998412404","https://openalex.org/W4386873877"],"related_works":["https://openalex.org/W2077240758","https://openalex.org/W2060330834","https://openalex.org/W2103854160","https://openalex.org/W1966593669","https://openalex.org/W1982044211","https://openalex.org/W2952714118","https://openalex.org/W2764332303","https://openalex.org/W1973624081","https://openalex.org/W2089988283","https://openalex.org/W2399242455"],"abstract_inverted_index":{"Our":[0,115,187],"group":[1],"of":[2,7,27,84,135,236],"studies":[3],"investigated":[4],"the":[5,12,36,47,50,58,119,125,167,173,179,196,209,218,225],"action":[6],"butane-2,3-dione":[8],"thiosemicarbazone":[9],"oxime":[10,37,120,163,168,191,204,219,238],"against":[11],"testicular":[13,226],"damage":[14,227],"caused":[15],"by":[16,54,131,147,152,158,162,185,200,213,229],"cadmium":[17,94,214],"chloride":[18],"(CdCl(2))":[19],"in":[20,123,127,139,171,175,194,223,231],"mice.":[21,232],"Mice":[22],"received":[23],"a":[24],"single":[25],"injection":[26],"CdCl(2":[28],")(5":[29],"mg/kg,":[30,39],"intraperitoneally)":[31],"and,":[32],"after":[33,46],"thirty":[34],"minutes,":[35],"(10":[38],"subcutaneously)":[40],"was":[41,121,156,160,169,192,205,221],"administered.":[42],"Twenty":[43],"four":[44],"hours":[45],"last":[48],"administration,":[49],"animals":[51],"were":[52,62,69,97,113,149],"killed":[53],"cervical":[55],"dislocation":[56],"and":[57,60,77,95,104,111,137,143,178,244],"testes":[59],"serum":[61],"removed":[63],"for":[64],"analysis.":[65],"The":[66,82,133,233],"parameters":[67],"determined":[68],"\u03b4-aminolevulinate":[70],"dehydratase":[71],"(\u03b4-ALA-D),":[72],"myeloperoxidase":[73],"(MPO),":[74],"glutathione-S-transferase":[75],"(GST)":[76],"glutathione":[78],"peroxidase":[79],"(GPx)":[80],"activities.":[81],"levels":[83,145,177,183],"thiobarbituric":[85],"acid-reactive":[86],"substances":[87],"(TBARS),":[88],"nonprotein":[89],"thiols":[90],"(NPSH),":[91],"ascorbic":[92],"acid,":[93],"testosterone":[96,210],"also":[98,150],"determined.":[99],"In":[100,165,202,216],"addition,":[101,166,203],"histological":[102,197],"analysis":[103],"cytokines":[105],"quantification":[106],"(IL-1,":[107],"IL-6,":[108,141],"IL-10,":[109,154],"TNF-\u03b1":[110,142],"IFN-\u03b3)":[112],"performed.":[114],"results":[116,188],"demonstrated":[117,189],"that":[118,190],"effective":[122,170,193,222],"restoring":[124,172],"inhibition":[126],"\u03b4-ALA-D":[128],"activity":[129],"induced":[130,146,184,199,228],"CdCl(2).":[132,186,201],"activation":[134],"MPO":[136],"increase":[138,174,208],"IL-1,":[140],"IFN-\u03b3":[144],"CdCl(2)":[148,230],"reduced":[151,157,212],"oxime.":[153],"which":[155],"cadmium,":[159],"restored":[161],"administration.":[164],"TBARS":[176],"reduction":[180],"on":[181],"NPSH":[182],"containing":[195],"alterations":[198],"able":[206],"to":[207,241],"levels,":[211],"exposure.":[215],"conclusion,":[217],"tested":[220],"reducing":[224],"beneficial":[234],"effects":[235],"this":[237],"are":[239],"related":[240],"its":[242],"antioxidant":[243],"anti-inflammatory":[245],"action.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}