{"id":"https://openalex.org/W2024462000","doi":"https://doi.org/10.1172/jci114299","title":"The preS1 antigen of hepatitis B virus is highly immunogenic at the T cell level in man.","display_name":"The preS1 antigen of hepatitis B virus is highly immunogenic at the T cell level in man.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2024462000","doi":"https://doi.org/10.1172/jci114299","mag":"2024462000","pmid":"https://pubmed.ncbi.nlm.nih.gov/2529268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/329792"},"language":"en","primary_location":{"id":"doi:10.1172/jci114299","doi":"https://doi.org/10.1172/jci114299","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114299","pdf_url":"http://www.jci.org/articles/view/114299/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114299/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070463166","display_name":"Carlo I. Ferrari","orcid":"https://orcid.org/0000-0002-5461-6842","observed_orcids":["https://orcid.org/0000-0002-5461-6842"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Ferrari","raw_affiliation_strings":["Cattedra di Malattie Infettive, Universit\u00e0 di Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universit\u00e0 di Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031164159","display_name":"Amalia Penna","orcid":"https://orcid.org/0000-0001-9663-1250","observed_orcids":["https://orcid.org/0000-0001-9663-1250"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Penna","raw_affiliation_strings":["Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039286311","display_name":"Antonio Bertoletti","orcid":"https://orcid.org/0000-0002-2942-0485","observed_orcids":["https://orcid.org/0000-0002-2942-0485"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Bertoletti","raw_affiliation_strings":["Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015328811","display_name":"Albertina Cavalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Cavalli","raw_affiliation_strings":["Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044038656","display_name":"Antonietta Valli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"A Valli","raw_affiliation_strings":["Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016397838","display_name":"Claudia Schianchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"C Schianchi","raw_affiliation_strings":["Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109359583","display_name":"Franco Fiaccadori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"F Fiaccadori","raw_affiliation_strings":["Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Malattie Infettive , Universita' di Parma , 43100 Parma , Italy;","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Cattedra di Malattie Infettive, Universita' di Parma, 43100 Parma, Italy; and","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"tResearch Institute ofScripps Clinic, Department ofMolecular and Experimental Medicine, La Jolla, California 92037","institution_ids":["https://openalex.org/I123431417","https://openalex.org/I4210146328"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.7286,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.92905544,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"84","issue":"4","first_page":"1314","last_page":"1319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pre-s1-antigen","display_name":"pre-S1 antigen","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pre-s2-antigen","display_name":"pre-S2 antigen","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.7940000295639038},{"id":"https://openalex.org/keywords/t-cell-immunogenicity","display_name":"T cell immunogenicity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hepatitis-b-vaccine","display_name":"hepatitis B vaccine","score":0.7599999904632568},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.796999990940094},{"id":"https://openalex.org/keywords/cd4-t-cell-clones","display_name":"CD4+ T cell clones","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2779909307","wikidata":"https://www.wikidata.org/wiki/Q1660181","display_name":"Immunogen","level":4,"score":0.8571370244026184},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7421925663948059},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.649069607257843},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6403393745422363},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5335037708282471},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.4808112382888794},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37647897005081177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3471129536628723},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3310760259628296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31942692399024963},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3057301342487335},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.24842768907546997},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13808327913284302}],"mesh":[{"descriptor_ui":"D000090266","descriptor_name":"Chromobox Protein Homolog 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014761","descriptor_name":"Viral Hepatitis Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017325","descriptor_name":"Hepatitis B Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci114299","doi":"https://doi.org/10.1172/jci114299","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114299","pdf_url":"http://www.jci.org/articles/view/114299/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:329792","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/329792","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2529268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2529268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci114299","doi":"https://doi.org/10.1172/jci114299","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114299","pdf_url":"http://www.jci.org/articles/view/114299/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2687148999","display_name":null,"funder_award_id":"AI 26626-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024462000.pdf","grobid_xml":"https://content.openalex.org/works/W2024462000.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W27307021","https://openalex.org/W1504144316","https://openalex.org/W1544257702","https://openalex.org/W1550457834","https://openalex.org/W1551214464","https://openalex.org/W1576503553","https://openalex.org/W1579254467","https://openalex.org/W1593689583","https://openalex.org/W1604356264","https://openalex.org/W1970600380","https://openalex.org/W1998135206","https://openalex.org/W2016328839","https://openalex.org/W2023494440","https://openalex.org/W2061734833","https://openalex.org/W2069480630","https://openalex.org/W2082644864","https://openalex.org/W2084602326","https://openalex.org/W2085833018","https://openalex.org/W2089451276","https://openalex.org/W2092431491","https://openalex.org/W2124731827","https://openalex.org/W2134216982","https://openalex.org/W2135438320","https://openalex.org/W2140718513","https://openalex.org/W2155586526","https://openalex.org/W2158012103","https://openalex.org/W2175735448","https://openalex.org/W2411619206","https://openalex.org/W2411917131","https://openalex.org/W4245836637"],"related_works":["https://openalex.org/W1631402034","https://openalex.org/W1492951013","https://openalex.org/W2767524834","https://openalex.org/W4235181163","https://openalex.org/W2025810603","https://openalex.org/W2361655466","https://openalex.org/W1552117346","https://openalex.org/W7061198413","https://openalex.org/W2728242435","https://openalex.org/W1990646285"],"abstract_inverted_index":{"14":[0,54],"hepatitis":[1,22,32],"B":[2,11,23,33],"vaccine":[3,26,103],"recipients":[4,104],"who":[5],"showed":[6,78],"high":[7],"titers":[8],"of":[9,31,82,95,101,109,122,137],"anti-hepatitis":[10],"surface":[12,24],"antibodies":[13],"in":[14,45,99,168],"serum":[15],"after":[16],"booster":[17],"immunization":[18],"with":[19],"a":[20,57,79,120,163],"polyvalent":[21],"antigen":[25,159],"that":[27,92,108,156],"contained":[28],"trace":[29],"amounts":[30],"virus":[34],"(HBV)":[35],"preS1":[36,144,158],"and":[37,119,146],"preS2":[38,148],"envelope":[39,66,125],"antigens":[40],"were":[41,130,140],"studied":[42],"for":[43],"their":[44],"vitro":[46],"T":[47,60,83,97,111,113,165],"cell":[48,61,84,114,166],"response":[49,62],"to":[50,63,73,86],"these":[51,102,138,153],"antigens.":[52],"All":[53],"subjects":[55],"displayed":[56],"significant":[58,80],"proliferative":[59],"the":[64,93,157],"S/p25":[65,141],"region":[67],"encoded":[68],"polypeptide;":[69],"8":[70],"also":[71],"responded":[72],"preS1,":[74],"while":[75],"only":[76],"1":[77,147],"level":[81],"proliferation":[85],"preS2.":[87],"Limiting":[88],"dilution":[89],"analysis":[90],"demonstrated":[91],"frequency":[94],"preS-specific":[96],"cells":[98],"two":[100,133],"was":[105,116],"higher":[106],"than":[107],"S/p25-specific":[110],"cells.":[112],"cloning":[115],"then":[117],"performed":[118],"total":[121],"29":[123],"HBV":[124],"antigen-reactive":[126],"CD4+":[127],"cloned":[128],"lines":[129,139],"generated":[131],"from":[132],"preS-responsive":[134],"vaccines.":[135],"21":[136],"specific,":[142,145],"7":[143],"specific.":[149],"Taken":[150],"together,":[151],"all":[152],"results":[154],"suggest":[155],"may":[160],"function":[161],"as":[162],"strong":[164],"immunogen":[167],"man.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}