{"id":"https://openalex.org/W2024438554","doi":"https://doi.org/10.1159/000226816","title":"Influence of Metoclopramide and Bromocriptine upon the Growth of Human and Murine Neuroblastoma Cells","display_name":"Influence of Metoclopramide and Bromocriptine upon the Growth of Human and Murine Neuroblastoma Cells","publication_year":2009,"publication_date":"2009-06-26","ids":{"openalex":"https://openalex.org/W2024438554","doi":"https://doi.org/10.1159/000226816","mag":"2024438554","pmid":"https://pubmed.ncbi.nlm.nih.gov/1969134"},"language":"en","primary_location":{"id":"doi:10.1159/000226816","doi":"https://doi.org/10.1159/000226816","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226816","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110395593","display_name":"E. Busse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Busse","raw_affiliation_strings":["Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD","Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036724454","display_name":"Oliver Bartsch","orcid":"https://orcid.org/0000-0001-6329-696X","observed_orcids":["https://orcid.org/0000-0001-6329-696X"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Bartsch","raw_affiliation_strings":["Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Schneider","raw_affiliation_strings":["Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110054716","display_name":"B. Kornhuber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Kornhuber","raw_affiliation_strings":["Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum der Kinderheilkunde, Abteilung f\u00fcr H\u00e4motologie und Onkologie, Johann-Wolfgang-Goethe-Universit\u00e4t, Frankfurt, BRD","institution_ids":["https://openalex.org/I114090438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114090438"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.18453417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"2","first_page":"199","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bromocriptine","display_name":"bromocriptine","score":1.0},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.921999990940094},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dopamine-binding","display_name":"dopamine binding","score":0.5139999985694885},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6940000057220459},{"id":"https://openalex.org/keywords/serum-copper","display_name":"serum copper","score":0.9169999957084656},{"id":"https://openalex.org/keywords/peripheral-blood-counts","display_name":"peripheral blood cell counts","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2776856834","wikidata":"https://www.wikidata.org/wiki/Q413581","display_name":"Bromocriptine","level":4,"score":0.806508481502533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7041909098625183},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7021476626396179},{"id":"https://openalex.org/C2778479196","wikidata":"https://www.wikidata.org/wiki/Q421095","display_name":"Metoclopramide","level":3,"score":0.693166971206665},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6554400324821472},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.5943344831466675},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5434924960136414},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5433810353279114},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45038464665412903},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4461796283721924},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4083629250526428},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.397779643535614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38507112860679626},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37634554505348206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1446792185306549},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1297335922718048},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001772","descriptor_name":"Blood Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008787","descriptor_name":"Metoclopramide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000226816","doi":"https://doi.org/10.1159/000226816","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000226816","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:1969134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1969134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2044096430","https://openalex.org/W2103990315","https://openalex.org/W2087537692","https://openalex.org/W2013370493","https://openalex.org/W1966907903","https://openalex.org/W2422782421","https://openalex.org/W2059088809","https://openalex.org/W2052939333","https://openalex.org/W4281658179","https://openalex.org/W2080677411"],"abstract_inverted_index":{"The":[0,160],"effects":[1,124],"of":[2,11,23,32,108,125],"metoclopramide":[3],"(MCP)":[4],"and":[5,15,43,61,79,117,127,149,173],"bromocriptine":[6],"(BC)":[7],"on":[8,18],"the":[9,19,29,68,73,105,109,113,120,123,138,152,166,175],"growth":[10,132,144,155],"neuroblastoma":[12],"(NB)":[13],"cells":[14,58,78],"their":[16],"influence":[17],"plasma":[20,110],"membrane":[21,111],"binding":[22,106],"several":[24],"neurotransmitters":[25],"were":[26,38,133,145],"studied.":[27],"In":[28,119],"first":[30],"part":[31],"this":[33],"study,":[34],"in":[35,59,76,92,135,137,142,156,170,174],"vitro":[36,60],"experiments":[37],"done":[39],"with":[40,165],"three":[41],"human":[42],"two":[44],"murine":[45],"NB":[46,57,77,130,153],"cell":[47,95],"lines.":[48],"Dibutyryl":[49],"cyclic":[50,100],"3',5'-adenosine":[51,101],"monophosphate":[52],"is":[53],"known":[54],"to":[55,98],"differentiate":[56],"served":[62],"as":[63,85,87],"a":[64,157],"reference":[65],"substance":[66],"during":[67],"experiments.":[69],"MCP":[70,103,128,150],"significantly":[71],"reduced":[72],"replication":[74],"rate":[75],"increased":[80,104],"cellular":[81],"differentiation":[82],"by":[83,88],"morphological":[84],"well":[86],"functional":[89],"criteria.":[90],"BC,":[91],"contrast,":[93],"stimulated":[94],"replication.":[96],"Similar":[97],"dibutyryl":[99],"monophosphate,":[102],"capacity":[107],"for":[112],"beta-adrenergic":[114],"hormones":[115],"dopamine":[116],"noradrenaline.":[118],"second":[121],"part,":[122],"BC":[126,147],"upon":[129],"tumor":[131,143,154],"investigated":[134],"vivo":[136],"mouse.":[139],"Significant":[140],"changes":[141,169],"induced;":[146],"promoted":[148],"inhibited":[151],"dose-dependent":[158],"relationship.":[159],"findings":[161],"are":[162],"discussed,":[163],"along":[164],"observed":[167],"accompanying":[168],"serum":[171],"copper":[172],"peripheral":[176],"blood":[177],"count.":[178]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
