{"id":"https://openalex.org/W202443568","doi":null,"title":"Determinants of disease severity in primary Sj\u00f6gren\u2019s syndrome","display_name":"Determinants of disease severity in primary Sj\u00f6gren\u2019s syndrome","publication_year":2014,"publication_date":"2014-11-11","ids":{"openalex":"https://openalex.org/W202443568","mag":"202443568"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/299916","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299916","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/299916","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112159323","display_name":"Anna P Risselada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna P Risselada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112159323"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/salivary-gland-histology","display_name":"salivary gland histology","score":0.9779999852180481},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9599999785423279},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.9169999957084656},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.5139999985694885},{"id":"https://openalex.org/keywords/extraglandular-manifestations","display_name":"extraglandular manifestations","score":0.7580000162124634},{"id":"https://openalex.org/keywords/vasculitis","display_name":"vasculitis","score":0.652999997138977},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8623065948486328},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.682660698890686},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.5516975522041321},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.5109716653823853},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47832441329956055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4539312422275543},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.44692158699035645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4427640438079834},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4291015863418579},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4234044849872589},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.4200475215911865},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3862614333629608},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34807059168815613},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3469238579273224},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/299916","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299916","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/299916","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299916","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/299916","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/299916","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:202443568","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/bitstream/1874/299916/1/AR_Book_08.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/299916","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/299916","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":177,"referenced_works":["https://openalex.org/W4633738","https://openalex.org/W15017595","https://openalex.org/W26013339","https://openalex.org/W72193657","https://openalex.org/W112689046","https://openalex.org/W118044844","https://openalex.org/W119393901","https://openalex.org/W172676584","https://openalex.org/W174502258","https://openalex.org/W1527009171","https://openalex.org/W1592663750","https://openalex.org/W1596938010","https://openalex.org/W1599848769","https://openalex.org/W1678932852","https://openalex.org/W1701395117","https://openalex.org/W1748698773","https://openalex.org/W1769013904","https://openalex.org/W1790195495","https://openalex.org/W1964113835","https://openalex.org/W1965158064","https://openalex.org/W1967834717","https://openalex.org/W1969338599","https://openalex.org/W1970895045","https://openalex.org/W1971387596","https://openalex.org/W1973295061","https://openalex.org/W1973533990","https://openalex.org/W1974030711","https://openalex.org/W1975092086","https://openalex.org/W1976199811","https://openalex.org/W1977100347","https://openalex.org/W1979369716","https://openalex.org/W1980627635","https://openalex.org/W1985012268","https://openalex.org/W1988081732","https://openalex.org/W1988476615","https://openalex.org/W1990197514","https://openalex.org/W1990227093","https://openalex.org/W1994088252","https://openalex.org/W1994855638","https://openalex.org/W1997948306","https://openalex.org/W1999996997","https://openalex.org/W2000671641","https://openalex.org/W2000969329","https://openalex.org/W2001847454","https://openalex.org/W2004696645","https://openalex.org/W2006629258","https://openalex.org/W2008394861","https://openalex.org/W2009603759","https://openalex.org/W2010111291","https://openalex.org/W2013192365","https://openalex.org/W2015995273","https://openalex.org/W2016307205","https://openalex.org/W2018509420","https://openalex.org/W2020510817","https://openalex.org/W2021654680","https://openalex.org/W2024308747","https://openalex.org/W2025608060","https://openalex.org/W2028514870","https://openalex.org/W2030711090","https://openalex.org/W2031978413","https://openalex.org/W2032094344","https://openalex.org/W2033913781","https://openalex.org/W2034528584","https://openalex.org/W2034882426","https://openalex.org/W2036003620","https://openalex.org/W2036440041","https://openalex.org/W2039623273","https://openalex.org/W2040098460","https://openalex.org/W2040113869","https://openalex.org/W2040158528","https://openalex.org/W2041619077","https://openalex.org/W2041765359","https://openalex.org/W2043239230","https://openalex.org/W2044072165","https://openalex.org/W2044570210","https://openalex.org/W2045106632","https://openalex.org/W2045779817","https://openalex.org/W2046545831","https://openalex.org/W2050442107","https://openalex.org/W2051333656","https://openalex.org/W2051597710","https://openalex.org/W2052059548","https://openalex.org/W2054934010","https://openalex.org/W2055671309","https://openalex.org/W2056009708","https://openalex.org/W2057102103","https://openalex.org/W2057332383","https://openalex.org/W2059189040","https://openalex.org/W2059903231","https://openalex.org/W2062121752","https://openalex.org/W2063943150","https://openalex.org/W2064622089","https://openalex.org/W2065856920","https://openalex.org/W2066772092","https://openalex.org/W2067407074","https://openalex.org/W2068113234","https://openalex.org/W2068439980","https://openalex.org/W2068784018","https://openalex.org/W2071131425","https://openalex.org/W2073531991","https://openalex.org/W2073650658","https://openalex.org/W2074112183","https://openalex.org/W2074759176","https://openalex.org/W2076563645","https://openalex.org/W2078924871","https://openalex.org/W2078958726","https://openalex.org/W2079670423","https://openalex.org/W2080894267","https://openalex.org/W2085412199","https://openalex.org/W2085452771","https://openalex.org/W2085927474","https://openalex.org/W2090838256","https://openalex.org/W2094910932","https://openalex.org/W2096073475","https://openalex.org/W2096334725","https://openalex.org/W2097783436","https://openalex.org/W2099163887","https://openalex.org/W2099430274","https://openalex.org/W2101075621","https://openalex.org/W2101382380","https://openalex.org/W2104594053","https://openalex.org/W2104961731","https://openalex.org/W2107202569","https://openalex.org/W2107908044","https://openalex.org/W2108393103","https://openalex.org/W2112346826","https://openalex.org/W2114351006","https://openalex.org/W2114850377","https://openalex.org/W2115283623","https://openalex.org/W2118981613","https://openalex.org/W2119179953","https://openalex.org/W2120385612","https://openalex.org/W2120713232","https://openalex.org/W2124127816","https://openalex.org/W2129127554","https://openalex.org/W2132180982","https://openalex.org/W2133054066","https://openalex.org/W2134342374","https://openalex.org/W2134547857","https://openalex.org/W2134654633","https://openalex.org/W2135808122","https://openalex.org/W2136147869","https://openalex.org/W2138879607","https://openalex.org/W2138899248","https://openalex.org/W2139639021","https://openalex.org/W2140193145","https://openalex.org/W2141866180","https://openalex.org/W2143105825","https://openalex.org/W2144768135","https://openalex.org/W2151557366","https://openalex.org/W2154059578","https://openalex.org/W2157978685","https://openalex.org/W2159708138","https://openalex.org/W2160501643","https://openalex.org/W2160675339","https://openalex.org/W2161633259","https://openalex.org/W2162411149","https://openalex.org/W2163433558","https://openalex.org/W2163879223","https://openalex.org/W2164540037","https://openalex.org/W2166409015","https://openalex.org/W2166684356","https://openalex.org/W2167192875","https://openalex.org/W2167385753","https://openalex.org/W2168610878","https://openalex.org/W2168877333","https://openalex.org/W2170025585","https://openalex.org/W2214327097","https://openalex.org/W2215806678","https://openalex.org/W2250040640","https://openalex.org/W2263954167","https://openalex.org/W2319059128","https://openalex.org/W2344337327","https://openalex.org/W2399266797","https://openalex.org/W2417395415","https://openalex.org/W2467637424","https://openalex.org/W4244409142"],"related_works":["https://openalex.org/W1990197514","https://openalex.org/W4411395329","https://openalex.org/W2144768135","https://openalex.org/W2419629526","https://openalex.org/W3023492609","https://openalex.org/W2556762163","https://openalex.org/W4399484569","https://openalex.org/W4390768270","https://openalex.org/W2952894662","https://openalex.org/W3004215176"],"abstract_inverted_index":{"Primary":[0],"Sj\u00f6gren\u2019s":[1,235],"syndrome":[2],"(pSS)":[3],"is":[4,29,42,58,189,226,241],"a":[5,161,175,197,242,299,314,332,354,401],"chronic":[6],"systemic":[7,351,382],"autoimmune":[8],"disease":[9,93,237,248,280,303,327,383,417],"primarily":[10],"targeting":[11],"salivary":[12,107,115],"and":[13,22,33,81,99,106,171,214,269,295,341,350,409],"lacrimal":[14],"glands,":[15],"leading":[16],"to":[17,121,246,261,320,345,369,396,415],"dryness":[18],"of":[19,26,38,51,92,104,114,128,141,144,163,166,178,186,194,199,202,219,223,324,348,356,374,391,419],"predominantly":[20],"eyes":[21],"mouth.":[23],"Additionally,":[24,372],"inflammation":[25,180],"other":[27,182],"organs":[28],"seen,":[30],"like":[31,102],"arthritis":[32],"skin":[34,203],"lesions.":[35],"The":[36,221,233,388],"risk":[37,65,177],"B":[39],"cell":[40],"lymphoma":[41,138,195,231],"increased":[43],"in":[44,67,75,133,139,181,196,205,209,212,217,255,271,279,290,335,339,379,400],"pSS":[45,52,274,326,358,420],"patients:":[46,200],"approximately":[47],"3":[48],"\u2013":[49,60],"11%":[50],"patient":[53,262],"will":[54,150],"be":[55,119,397,413],"affected,":[56],"which":[57,250],"15":[59],"18x":[61],"higher":[62,176,378],"than":[63],"the":[64,68,76,90,112,134,192,272,288,322,325,336,346],"seen":[66],"general":[69,273],"population.":[70],"This":[71],"retrospective":[72],"research":[73],"performed":[74],"UMC":[77],"Utrecht":[78],"(195":[79],"patients)":[80,87],"St.":[82],"Antonius":[83],"Hospital":[84],"Nieuwegein":[85],"(65":[86],"focusses":[88],"on":[89],"prediction":[91],"severity":[94,323],"by":[95],"using":[96],"clinical":[97,256],"manifestations":[98,225],"diagnostic":[100],"tests":[101],"presence":[103,193,222],"auto-antibodies":[105,164],"gland":[108,116],"histology.":[109],"Most":[110],"importantly,":[111],"results":[113],"histology":[117],"can":[118,412],"used":[120,414],"estimate":[122,416],"prognosis.":[123],"Patients":[124],"with":[125,146,156,191,381],"\u22653":[126],"clusters":[127,148,159],"lymphocytes":[129],"per":[130],"4":[131],"mm2":[132],"biopsy":[135],"specimen":[136],"develop":[137,152],"14%":[140],"patients,":[142],"whereas":[143],"patients":[145,155,359,380],"less":[147],"98%":[149],"NOT":[151],"lymphoma.":[153],"Furthermore,":[154],"more":[157],"inflammatory":[158,224],"and/or":[160],"diversity":[162],"(\u22653":[165],"ANA,":[167],"rheumatoid":[168],"factor,":[169],"anti-SSA":[170],"anti-SSB":[172],"antibodies)":[173],"have":[174],"developing":[179],"organs.":[183],"New":[184],"occurrence":[185],"certain":[187,291],"symptoms":[188],"associated":[190],"percentage":[198],"vasculitis":[201],"(purpura)":[204],"16%,":[206],"peripheral":[207],"neuropathy":[208],"24%,":[210],"glomerulonephritis":[211],"100%":[213],"IgM-kappa":[215],"paraprotein":[216],"64%":[218],"cases.":[220],"important":[227],"for":[228,302],"decisions":[229],"regarding":[230],"treatment.":[232],"EULAR":[234],"Syndrome":[236],"activity":[238,249,281],"index":[239],"(ESSDAI)":[240],"novel":[243],"European":[244],"score":[245,317],"assess":[247],"has":[251,395],"not":[252],"been":[253],"tested":[254],"practice,":[257],"yet.":[258],"Retrospectively":[259],"applied":[260],"charts,":[263],"mean":[264],"ESSDAI":[265,306,316],"scores":[266,289,308],"are":[267,282,298],"low":[268],"stable":[270],"population,":[275],"but":[276],"individual":[277],"changes":[278],"well":[283],"captured.":[284],"Questions":[285],"remain":[286],"whether":[287],"domains,":[292,297],"e.g.":[293],"pulmonary":[294],"muscular":[296],"good":[300],"representative":[301],"severity.":[304],"Since":[305],"only":[307],"new":[309],"or":[310],"worsening":[311],"manifestations,":[312],"calculating":[313],"cumulative":[315],"was":[318],"proposed":[319],"describe":[321],"course.":[328],"Interleukin-7":[329],"(IL-7)":[330],"plays":[331],"critical":[333],"role":[334],"immunopathologic":[337],"pathways":[338],"pSS,":[340],"IL-7":[342],"levels":[343,364,373],"correlate":[344],"extent":[347],"local":[349],"disease.":[352],"In":[353,404],"cohort":[355],"41":[357],"soluble":[360],"IL7":[361],"receptor":[362],"(sIL7r)":[363],"were":[365,376],"significantly":[366,377],"increased,":[367],"compared":[368],"age-matched":[370],"controls.":[371],"sIL7r":[375,392],"during":[384],"10":[385],"year":[386],"follow-up.":[387],"additive":[389],"value":[390],"as":[393],"biomarker":[394],"further":[398],"studied":[399],"larger":[402],"cohort.":[403],"conclusion,":[405],"several":[406],"clinical,":[407],"laboratory":[408],"histologic":[410],"markers":[411],"prognosis":[418],"patients.":[421]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
