{"id":"https://openalex.org/W2024435329","doi":"https://doi.org/10.1182/blood-2002-07-2018","title":"Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress\u2013induced apoptosis","display_name":"Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress\u2013induced apoptosis","publication_year":2003,"publication_date":"2003-05-20","ids":{"openalex":"https://openalex.org/W2024435329","doi":"https://doi.org/10.1182/blood-2002-07-2018","mag":"2024435329","pmid":"https://pubmed.ncbi.nlm.nih.gov/12586632"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2002-07-2018","doi":"https://doi.org/10.1182/blood-2002-07-2018","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2002-07-2018","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025921282","display_name":"Rosalie M. Luiten","orcid":"https://orcid.org/0000-0002-0800-0721","observed_orcids":["https://orcid.org/0000-0002-0800-0721"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Rosalie M. Luiten","raw_affiliation_strings":["From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040746428","display_name":"J\u00e9r\u00f4me P\u00e8ne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Je\u0301ro\u0302me Pe\u0300ne","raw_affiliation_strings":["From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036491309","display_name":"Hans Yssel","orcid":"https://orcid.org/0000-0001-7454-1836","observed_orcids":["https://orcid.org/0000-0001-7454-1836"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Hans Yssel","raw_affiliation_strings":["From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089955013","display_name":"Hergen Spits","orcid":"https://orcid.org/0000-0003-3269-8338","observed_orcids":["https://orcid.org/0000-0003-3269-8338"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Hergen Spits","raw_affiliation_strings":["From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands; and the Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM) U454, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.0209,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.91723889,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"101","issue":"11","first_page":"4512","last_page":"4519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.8740000128746033},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.8939999938011169},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7670000195503235},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.8809999823570251},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-cell-clones","display_name":"T cell clones","score":0.7390000224113464},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.8342146873474121},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7498582601547241},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.7323662638664246},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7069984674453735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6729053854942322},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6164637804031372},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5641214847564697},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.499159574508667},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48160502314567566},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47569286823272705},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.45138153433799744},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4486706554889679},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35818642377853394},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3398120105266571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19167008996009827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12831807136535645}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1182/blood-2002-07-2018","doi":"https://doi.org/10.1182/blood-2002-07-2018","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2002-07-2018","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:12586632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12586632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/e5b9466f-86fb-4ef5-a4d9-3da76925d0c3","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/e5b9466f-86fb-4ef5-a4d9-3da76925d0c3","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Luiten, R M, P\u00e9ne, J, Yssel, H & Spits, H 2003, 'Ectopic hTERT expression extends the life span of human CD4(+) helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis', Blood, vol. 101, no. 11, pp. 4512-4519. https://doi.org/10.1182/blood-2002-07-2018","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/2d42b5ab-9c8a-4c09-b3a3-56a8508170ed","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/ectopic-htert-expression-extends-the-life-span-of-human-cd4-helper-and-regulatory-tcell-clones-and-confers-resistance-to-oxidative-stressinduced-apoptosis(2d42b5ab-9c8a-4c09-b3a3-56a8508170ed).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 101(11), 4512 - 4519. American Society of Hematology","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2740410151","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Rosalie_Luiten/publication/10899752_Ectopic_hTERT_expression_extends_the_life_span_of_human_CD4_helper_and_regulatory_T-cell_clones_and_confers_resistance_to_oxidative_stress-induced_apoptosis/links/0deec52932e07967bb000000.pdf?disableCoverPage=true","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W199729741","https://openalex.org/W1521209045","https://openalex.org/W1574658543","https://openalex.org/W1611610664","https://openalex.org/W1679527748","https://openalex.org/W1968325292","https://openalex.org/W1973573758","https://openalex.org/W1977225005","https://openalex.org/W1982538054","https://openalex.org/W1983673827","https://openalex.org/W2025791374","https://openalex.org/W2027598856","https://openalex.org/W2030288414","https://openalex.org/W2030490116","https://openalex.org/W2045928865","https://openalex.org/W2052260390","https://openalex.org/W2054678965","https://openalex.org/W2057392346","https://openalex.org/W2060975096","https://openalex.org/W2062591638","https://openalex.org/W2063096720","https://openalex.org/W2067809407","https://openalex.org/W2088672106","https://openalex.org/W2090325842","https://openalex.org/W2096448104","https://openalex.org/W2100550233","https://openalex.org/W2106291988","https://openalex.org/W2108482850","https://openalex.org/W2139137777","https://openalex.org/W2140627356","https://openalex.org/W2142865919","https://openalex.org/W2147646689","https://openalex.org/W2314273878"],"related_works":["https://openalex.org/W2740410151","https://openalex.org/W2057392346","https://openalex.org/W1995552443","https://openalex.org/W2091428457","https://openalex.org/W7095348641","https://openalex.org/W7015557542","https://openalex.org/W2096448104","https://openalex.org/W2333403728","https://openalex.org/W2146966857","https://openalex.org/W1968325292"],"abstract_inverted_index":{"Human":[0],"somatic":[1],"cells":[2,43,106,162,168,180,208],"have":[3,54],"a":[4],"limited":[5],"life":[6,38,62],"span":[7,39,63],"in":[8,80,101,136,192],"vitro.":[9],"Upon":[10],"aging":[11],"and":[12,72,76,169],"with":[13,175],"each":[14],"cell":[15,26,92,123,148,152],"division,":[16],"shortening":[17],"of":[18,40,64,107,128,150,158,166],"telomeres":[19],"occurs,":[20],"which":[21,187],"eventually":[22],"will":[23],"lead":[24],"to":[25,35,99,120,146,184,216],"cycle":[27],"arrest.":[28],"Ectopic":[29],"hTERT":[30,58,201],"expression":[31,59,202],"has":[32],"been":[33],"shown":[34,55],"extend":[36],"the":[37,50,61,79,108,144],"human":[41],"T":[42,66,161,207],"by":[44,219],"preventing":[45],"this":[46],"telomere":[47],"erosion.":[48],"In":[49,90],"present":[51],"study,":[52],"we":[53],"that":[56,199],"ectopic":[57,94,113,200],"extends":[60],"CD4+":[65],"helper":[67],"type":[68],"1":[69],"or":[70,126],"2":[71],"regulatory":[73],"T-cell":[74,131],"clones":[75,96],"affected":[77],"neither":[78],"vitro":[81],"cytokine":[82],"production":[83],"profile":[84],"nor":[85],"their":[86],"specificity":[87],"for":[88],"antigen.":[89],"mixed":[91],"cultures,":[93],"hTERT-expressing":[95],"were":[97,181],"found":[98],"expand":[100],"greater":[102],"numbers":[103],"than":[104],"untransduced":[105],"same":[109],"replicative":[110,210],"age.":[111],"This":[112],"hTERT-induced":[114],"growth":[115],"advantage":[116],"was":[117,154],"not":[118,203],"due":[119],"an":[121],"enhanced":[122],"division":[124],"rate":[125],"number":[127],"divisions":[129],"following":[130],"receptor-mediated":[132],"activation,":[133],"as":[134],"determined":[135],"carboxyfluorescein":[137],"diacetate":[138],"succinimidyl":[139],"ester":[140],"(CFSE)-labeling":[141],"experiments.":[142],"Moreover,":[143],"susceptibility":[145],"activation-induced":[147],"death":[149],"both":[151],"types":[153],"similar.":[155],"However,":[156],"cultures":[157],"resting":[159],"hTERT-transduced":[160,179],"contained":[163],"higher":[164],"frequencies":[165],"Bcl-2-expressing":[167],"lower":[170],"active":[171],"caspase-3-expressing":[172],"cells,":[173],"compared":[174],"wild-type":[176],"cells.":[177],"Furthermore,":[178],"more":[182],"resistant":[183],"oxidative":[185,220],"stress,":[186],"causes":[188],"preferential":[189],"DNA":[190],"damage":[191],"telomeres.":[193],"Taken":[194],"together,":[195],"these":[196],"results":[197],"show":[198],"only":[204],"protects":[205],"proliferating":[206],"from":[209],"senescence":[211],"but":[212],"also":[213],"confers":[214],"resistance":[215],"apoptosis":[217],"induced":[218],"stress.":[221]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}