{"id":"https://openalex.org/W2024405236","doi":"https://doi.org/10.1172/jci42345","title":"Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas","display_name":"Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas","publication_year":2010,"publication_date":"2010-02-23","ids":{"openalex":"https://openalex.org/W2024405236","doi":"https://doi.org/10.1172/jci42345","mag":"2024405236","pmid":"https://pubmed.ncbi.nlm.nih.gov/20179347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2827970"},"language":"en","primary_location":{"id":"doi:10.1172/jci42345","doi":"https://doi.org/10.1172/jci42345","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci42345","pdf_url":"http://www.jci.org/articles/view/42345/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/42345/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014733785","display_name":"Jeffrey Peter Greenfield","orcid":"https://orcid.org/0000-0003-1904-1040","observed_orcids":["https://orcid.org/0000-0003-1904-1040"]},"institutions":[{"id":"https://openalex.org/I4210109411","display_name":"Children's Cancer and Blood Foundation","ror":"https://ror.org/01p7z6793","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210109411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey P. Greenfield","raw_affiliation_strings":["Pediatric Brain Tumor Research and Children's Cancer and Blood Foundation Laboratories, Champalimaud Metastasis Programme, New York, New York, USA. jpgreenf@med.cornell.edu","Pediatric Brain Tumor Research and Children's Cancer and Blood Foundation Laboratories, Champalimaud Metastasis Programme, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Research and Children's Cancer and Blood Foundation Laboratories, Champalimaud Metastasis Programme, New York, New York, USA. jpgreenf@med.cornell.edu","institution_ids":["https://openalex.org/I4210109411"]},{"raw_affiliation_string":"Pediatric Brain Tumor Research and Children's Cancer and Blood Foundation Laboratories, Champalimaud Metastasis Programme, New York, New York, USA","institution_ids":["https://openalex.org/I4210109411"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William S. Cobb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William S. Cobb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044701800","display_name":"David C. Lyden","orcid":"https://orcid.org/0000-0003-0193-4131","observed_orcids":["https://orcid.org/0000-0003-0193-4131"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Lyden","raw_affiliation_strings":["Department of Pediatrics , Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center , New York , New York","Pediatric Brain Tumor Research and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics , Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center , New York , New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Pediatric Brain Tumor Research and the","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.1841,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.75308406,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"120","issue":"3","first_page":"663","last_page":"667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-malignant-glioma","display_name":"recurrent malignant glioma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/vasculogenesis","display_name":"vasculogenesis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gliomagenesis","display_name":"gliomagenesis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.8270000219345093},{"id":"https://openalex.org/keywords/glioma-progression","display_name":"glioma progression","score":0.6470000147819519},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C60781801","wikidata":"https://www.wikidata.org/wiki/Q1424593","display_name":"Vasculogenesis","level":4,"score":0.8871758580207825},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8073581457138062},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6538896560668945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5922785997390747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5477924346923828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26469123363494873},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.14226165413856506},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07179233431816101},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000080027","descriptor_name":"Cyclams","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001596","descriptor_name":"Benzylamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006571","descriptor_name":"Heterocyclic Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039481","descriptor_name":"CD11b Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci42345","doi":"https://doi.org/10.1172/jci42345","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci42345","pdf_url":"http://www.jci.org/articles/view/42345/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2827970","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2827970","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:20179347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20179347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci42345","doi":"https://doi.org/10.1172/jci42345","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci42345","pdf_url":"http://www.jci.org/articles/view/42345/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306777","display_name":"National Foundation for Cancer Research","ror":"https://ror.org/04v83ky93"},{"id":"https://openalex.org/F4320309331","display_name":"Hartwell Foundation","ror":"https://ror.org/038cgyc59"},{"id":"https://openalex.org/F4320328273","display_name":"Funda\u00e7\u00e3o Champalimaud","ror":"https://ror.org/03g001n57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024405236.pdf","grobid_xml":"https://content.openalex.org/works/W2024405236.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1485875137","https://openalex.org/W1585754595","https://openalex.org/W1892975896","https://openalex.org/W1965346422","https://openalex.org/W1970849733","https://openalex.org/W1977392502","https://openalex.org/W1978041336","https://openalex.org/W1980275866","https://openalex.org/W1989838140","https://openalex.org/W2001009247","https://openalex.org/W2002727873","https://openalex.org/W2021268612","https://openalex.org/W2032118383","https://openalex.org/W2053674306","https://openalex.org/W2058901785","https://openalex.org/W2078481843","https://openalex.org/W2078924802","https://openalex.org/W2085241853","https://openalex.org/W2096287682","https://openalex.org/W2098611941","https://openalex.org/W2100303404","https://openalex.org/W2109947902","https://openalex.org/W2115538252","https://openalex.org/W2139877124","https://openalex.org/W2169424184"],"related_works":["https://openalex.org/W2060959126","https://openalex.org/W1990824001","https://openalex.org/W2024059336","https://openalex.org/W7100001240","https://openalex.org/W37613957","https://openalex.org/W350102749","https://openalex.org/W2090171472","https://openalex.org/W2381681695","https://openalex.org/W2577946238","https://openalex.org/W2006527466"],"abstract_inverted_index":{"The":[0,16],"cellular":[1],"and":[2,7,44,55],"molecular":[3],"events":[4],"that":[5,42,60],"initiate":[6],"promote":[8,21],"malignant":[9,57],"glioma":[10],"development":[11],"are":[12,24],"not":[13],"completely":[14],"understood.":[15],"treatment":[17],"modalities":[18],"designed":[19],"to":[20,29],"its":[22],"demise":[23],"all":[25],"ultimately":[26],"ineffective,":[27],"leading":[28],"disease":[30],"progression.":[31],"In":[32],"this":[33],"issue":[34],"of":[35,53,78],"the":[36,51,69],"JCI,":[37],"Kioi":[38],"et":[39],"al.":[40],"demonstrate":[41],"vasculogenesis":[43],"angiogenesis":[45],"potentially":[46],"play":[47],"distinct":[48],"roles":[49],"in":[50],"etiology":[52],"primary":[54],"recurrent":[56],"gliomas,":[58],"suggesting":[59],"patient":[61],"therapy":[62],"should":[63],"perhaps":[64],"be":[65],"tailored":[66],"specifically":[67],"against":[68],"predominant":[70],"vasculature":[71],"pathway":[72],"at":[73],"a":[74],"given":[75],"specific":[76],"stage":[77],"gliomagenesis.":[79]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}