{"id":"https://openalex.org/W2024348100","doi":"https://doi.org/10.1159/000246897","title":"Topical Haemotherapy for Leg Ulcers","display_name":"Topical Haemotherapy for Leg Ulcers","publication_year":2009,"publication_date":"2009-10-07","ids":{"openalex":"https://openalex.org/W2024348100","doi":"https://doi.org/10.1159/000246897","mag":"2024348100","pmid":"https://pubmed.ncbi.nlm.nih.gov/7873834"},"language":"en","primary_location":{"id":"doi:10.1159/000246897","doi":"https://doi.org/10.1159/000246897","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000246897","pdf_url":null,"source":{"id":"https://openalex.org/S135397728","display_name":"Dermatology","issn_l":"1018-8665","issn":["1018-8665","1421-9832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029339602","display_name":"B. Triquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B. Triquet","raw_affiliation_strings":["Department of Dermatology, University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079294648","display_name":"P. Ruffieux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P. Ruffieux","raw_affiliation_strings":["Department of Dermatology, University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082718014","display_name":"Carlo Mainetti","orcid":"https://orcid.org/0000-0001-6999-5593","observed_orcids":["https://orcid.org/0000-0001-6999-5593"]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Mainetti","raw_affiliation_strings":["Department of Dermatology, University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Salomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Salomon","raw_affiliation_strings":["Department of Dermatology, University Hospital, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014865981","display_name":"J.\u2010H. Saurat","orcid":"https://orcid.org/0000-0002-6668-2337","observed_orcids":["https://orcid.org/0000-0002-6668-2337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.-H. Saurat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6791,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75228162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"189","issue":"4","first_page":"418","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-leg-ulcers","display_name":"chronic leg ulcers","score":0.9369999766349792},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.7749999761581421},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8730000257492065},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.859000027179718},{"id":"https://openalex.org/keywords/autologous-skin-grafts","display_name":"autologous skin grafting","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.8457639813423157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.806962251663208},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6607380509376526},{"id":"https://openalex.org/C2777750529","wikidata":"https://www.wikidata.org/wiki/Q1591440","display_name":"Skin grafting","level":2,"score":0.6391124725341797},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5375944972038269},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4708423316478729},{"id":"https://openalex.org/C2781051411","wikidata":"https://www.wikidata.org/wiki/Q2078852","display_name":"Chronic wound","level":3,"score":0.42952635884284973}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007871","descriptor_name":"Leg Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007871","descriptor_name":"Leg Ulcer","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009779","descriptor_name":"Occlusive Dressings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000246897","doi":"https://doi.org/10.1159/000246897","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000246897","pdf_url":null,"source":{"id":"https://openalex.org/S135397728","display_name":"Dermatology","issn_l":"1018-8665","issn":["1018-8665","1421-9832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology","raw_type":"journal-article"},{"id":"pmid:7873834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7873834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatology (Basel, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028901430","https://openalex.org/W3044141885","https://openalex.org/W4416790632","https://openalex.org/W2732651143","https://openalex.org/W2574722297","https://openalex.org/W2165054101","https://openalex.org/W4237683130","https://openalex.org/W2149837482","https://openalex.org/W2994684949","https://openalex.org/W2121492654"],"abstract_inverted_index":{"Several":[0],"growth":[1],"factors,":[2],"present":[3],"in":[4,14,130],"the":[5,46,51,74,77,92,122],"plasma":[6],"or":[7,87],"delivered":[8],"by":[9,25,121],"blood":[10,31,123],"cells,":[11],"are":[12],"involved":[13],"wound":[15],"healing.":[16],"We":[17],"have":[18],"treated":[19],"15":[20],"chronic":[21,108],"atonic":[22],"leg":[23,109],"ulcers":[24,110],"topical":[26],"application":[27],"of":[28,50,61,73,76,107],"autologous":[29,82],"heparinized":[30],"under":[32],"a":[33,59,127],"hydrocolloidal":[34],"dressing.":[35],"This":[36],"'topical":[37],"haemotherapy'":[38],"(THT)":[39],"was":[40],"applied":[41],"every":[42],"other":[43],"day.":[44],"After":[45,58],"first":[47],"THT,":[48],"30%":[49],"fibrinonecrotic":[52],"material":[53],"had":[54],"already":[55],"been":[56],"removed.":[57],"mean":[60],"9":[62],"THT":[63,94],"applications":[64],"(range:":[65,79],"5-18),":[66],"granulation":[67,114],"tissue":[68],"covered":[69],"up":[70],"to":[71],"75%":[72],"surface":[75],"ulcer":[78],"30-100%)":[80],"allowing":[81],"skin":[83],"grafting.":[84],"No":[85],"local":[86],"systemic":[88],"side-effects":[89],"occurred":[90],"during":[91],"treatment.":[93],"is":[95,101],"feasible":[96],"and":[97,104,118],"well":[98],"tolerated;":[99],"it":[100],"an":[102],"easy":[103],"inexpensive":[105],"treatment":[106],"that":[111],"rapidly":[112],"induces":[113],"tissue.":[115],"Growth":[116],"factors":[117],"proteases":[119],"produced":[120],"cells":[124],"could":[125],"play":[126],"relevant":[128],"role":[129],"this":[131],"process.":[132]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}