{"id":"https://openalex.org/W2024324088","doi":"https://doi.org/10.1002/hep.21745","title":"Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers","display_name":"Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers","publication_year":2007,"publication_date":"2007-08-02","ids":{"openalex":"https://openalex.org/W2024324088","doi":"https://doi.org/10.1002/hep.21745","mag":"2024324088","pmid":"https://pubmed.ncbi.nlm.nih.gov/17668884"},"language":"en","primary_location":{"id":"doi:10.1002/hep.21745","doi":"https://doi.org/10.1002/hep.21745","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.21745","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.21745","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.21745","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030303456","display_name":"Marc Brulport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]},{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Marc Brulport","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany. brulport@ifado.de","Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Henryk Zulewski, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","Jan G. Hengstler, Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Hebelstra\u00dfe 22, CH-4031 Basel, Switzerland===","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","Marc Brulport, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany==="],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany. brulport@ifado.de","institution_ids":["https://openalex.org/I4210166399"]},{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Henryk Zulewski, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","institution_ids":["https://openalex.org/I4210166399"]},{"raw_affiliation_string":"Jan G. Hengstler, Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Hebelstra\u00dfe 22, CH-4031 Basel, Switzerland===","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]},{"raw_affiliation_string":"Marc Brulport, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079304983","display_name":"Wiebke Schormann","orcid":"https://orcid.org/0000-0003-3055-2706","observed_orcids":["https://orcid.org/0000-0003-3055-2706"]},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wiebke Schormann","raw_affiliation_strings":["Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084543023","display_name":"Alexander Bauer","orcid":"https://orcid.org/0000-0001-5262-4315","observed_orcids":["https://orcid.org/0000-0001-5262-4315"]},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Bauer","raw_affiliation_strings":["Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111601883","display_name":"Matthias Hermes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Hermes","raw_affiliation_strings":["Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049249101","display_name":"Carolin Elsner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Elsner","raw_affiliation_strings":["Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013006939","display_name":"Friedrich Jakob Hammersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedrich Jakob Hammersen","raw_affiliation_strings":["Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039861046","display_name":"Walter Beerheide","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Beerheide","raw_affiliation_strings":["Siam Life Science, Limited, Suriyawong Bangrak, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siam Life Science, Limited, Suriyawong Bangrak, Bangkok, Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113774902","display_name":"Dimitry Spitkovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dimitry Spitkovsky","raw_affiliation_strings":["Institute for Vegetative Physiology, University of Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Vegetative Physiology, University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103847497","display_name":"Wolfgang H\u00e4rtig","orcid":"https://orcid.org/0000-0002-1904-0796","observed_orcids":["https://orcid.org/0000-0002-1904-0796"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang H\u00e4rtig","raw_affiliation_strings":["Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026380931","display_name":"Andreas Klaus Nussler","orcid":"https://orcid.org/0000-0002-6666-6791","observed_orcids":["https://orcid.org/0000-0002-6666-6791"]},"institutions":[{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]},{"id":"https://openalex.org/I4210142323","display_name":"Neovii Biotech (Germany)","ror":"https://ror.org/043f79m81","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210142323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Nussler","raw_affiliation_strings":["Fresenius Biotech GmbH, Bad Homburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Biotech GmbH, Bad Homburg, Germany","institution_ids":["https://openalex.org/I4210108778","https://openalex.org/I4210142323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107318975","display_name":"Lars Christian Horn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Christian Horn","raw_affiliation_strings":["Institute of Pathology, Division of Gynaecopathology, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Division of Gynaecopathology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108426986","display_name":"Jeanett Edelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jeanett Edelmann","raw_affiliation_strings":["Institute of Legal Medicine, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Legal Medicine, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024885448","display_name":"Oliver Pelz-Ackermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Pelz-Ackermann","raw_affiliation_strings":["Laboratory of Molecular Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine, Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113556175","display_name":"J\u00f6rg Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137251492","display_name":"Leibniz Institute of Virology (LIV)","ror":"https://ror.org/02r2q1d96","country_code":"DE","type":"facility","lineage":["https://openalex.org/I137251492","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Petersen","raw_affiliation_strings":["Heinrich Pette Institute for Experimental Virology, University of Hamburg, Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heinrich Pette Institute for Experimental Virology, University of Hamburg, Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I137251492","https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006517477","display_name":"Manja Kamprad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manja Kamprad","raw_affiliation_strings":["Institute of Clinical Immunology, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Immunology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005023216","display_name":"Marc von Mach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc von Mach","raw_affiliation_strings":["II Medical Department, University of Mainz, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"II Medical Department, University of Mainz, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038796778","display_name":"Amelie Lupp","orcid":"https://orcid.org/0000-0003-0141-7310","observed_orcids":["https://orcid.org/0000-0003-0141-7310"]},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Amelie Lupp","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062976269","display_name":"Henryk Zulewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]},{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Henryk Zulewski","raw_affiliation_strings":["Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Basel, Switzerland","Henryk Zulewski, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","Jan G. Hengstler and Henryk Zulewski share senior authorship","Jan G. Hengstler, Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Hebelstra\u00dfe 22, CH-4031 Basel, Switzerland===","Marc Brulport, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany==="],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Henryk Zulewski, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","institution_ids":["https://openalex.org/I4210166399"]},{"raw_affiliation_string":"Jan G. Hengstler and Henryk Zulewski share senior authorship","institution_ids":[]},{"raw_affiliation_string":"Jan G. Hengstler, Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Hebelstra\u00dfe 22, CH-4031 Basel, Switzerland===","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Marc Brulport, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","institution_ids":["https://openalex.org/I4210166399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044367456","display_name":"Jan Georg Hengstler","orcid":"https://orcid.org/0000-0002-1427-5246","observed_orcids":["https://orcid.org/0000-0002-1427-5246"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]},{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Jan G. Hengstler","raw_affiliation_strings":["Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","Henryk Zulewski, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","Jan G. Hengstler and Henryk Zulewski share senior authorship","Jan G. Hengstler, Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Hebelstra\u00dfe 22, CH-4031 Basel, Switzerland===","Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","Marc Brulport, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany==="],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Toxicology, Institute of Legal Medicine and Rudolf-Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Henryk Zulewski, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","institution_ids":["https://openalex.org/I4210166399"]},{"raw_affiliation_string":"Jan G. Hengstler and Henryk Zulewski share senior authorship","institution_ids":[]},{"raw_affiliation_string":"Jan G. Hengstler, Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Hebelstra\u00dfe 22, CH-4031 Basel, Switzerland===","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany","institution_ids":["https://openalex.org/I4210166399"]},{"raw_affiliation_string":"Marc Brulport, Leibniz Research Centre for Working Environment and Human Factors, Ardeystra\u00dfe 67, D-44139 Dortmund, Germany===","institution_ids":["https://openalex.org/I4210166399"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5030303456","https://openalex.org/A5044367456","https://openalex.org/A5062976269"],"corresponding_institution_ids":["https://openalex.org/I2802542264","https://openalex.org/I4210166399","https://openalex.org/I926574661"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":10.9336,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.98728497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"3","first_page":"861","last_page":"870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-stem-cells","display_name":"human stem cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/precursor-cells","display_name":"precursor cells","score":0.6579999923706055},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"horizontal gene transfer","score":0.968999981880188},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.8980000019073486},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.6349999904632568},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7749999761581421},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pancreatic-cells","display_name":"pancreatic cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nod-scid-mice","display_name":"NOD/SCID mice","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mixed-cell-populations","display_name":"mixed cell populations","score":0.44699999690055847},{"id":"https://openalex.org/keywords/partial-differentiation","display_name":"partial differentiation","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.8996249437332153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7108272910118103},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6184649467468262},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5839416980743408},{"id":"https://openalex.org/C138851942","wikidata":"https://www.wikidata.org/wiki/Q4747406","display_name":"Amniotic epithelial cells","level":5,"score":0.43964913487434387},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.43742942810058594},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4372228980064392},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.40301790833473206},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35554325580596924},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35075512528419495},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34965789318084717},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.29548776149749756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2008504867553711},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12756764888763428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09819549322128296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08840659260749817}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.21745","doi":"https://doi.org/10.1002/hep.21745","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.21745","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.21745","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:17668884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17668884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:fraunhofer.de:N-75021","doi":null,"is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/N-75021.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer IZI","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/214614","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/214614","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1002/hep.21745","doi":"https://doi.org/10.1002/hep.21745","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.21745","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.21745","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2024324088.pdf"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1966450565","https://openalex.org/W1973278012","https://openalex.org/W1976895035","https://openalex.org/W1979499836","https://openalex.org/W1982022033","https://openalex.org/W2002282552","https://openalex.org/W2006749692","https://openalex.org/W2007964754","https://openalex.org/W2010463798","https://openalex.org/W2017380992","https://openalex.org/W2020375403","https://openalex.org/W2027264065","https://openalex.org/W2032105048","https://openalex.org/W2040404307","https://openalex.org/W2055071452","https://openalex.org/W2056361728","https://openalex.org/W2061141747","https://openalex.org/W2066439022","https://openalex.org/W2068460003","https://openalex.org/W2073454501","https://openalex.org/W2075284857","https://openalex.org/W2087990357","https://openalex.org/W2095192751","https://openalex.org/W2101693715","https://openalex.org/W2109191124","https://openalex.org/W2113106533","https://openalex.org/W2123389370","https://openalex.org/W2140675859","https://openalex.org/W2147164277","https://openalex.org/W2150646028","https://openalex.org/W2153773005","https://openalex.org/W2154502936","https://openalex.org/W2425787395","https://openalex.org/W4211173486","https://openalex.org/W4285719527","https://openalex.org/W6807366397"],"related_works":["https://openalex.org/W2017380992","https://openalex.org/W2386723792","https://openalex.org/W2087990357","https://openalex.org/W2572199427","https://openalex.org/W2030100501","https://openalex.org/W2488275614","https://openalex.org/W2980159556","https://openalex.org/W2082929405","https://openalex.org/W2006749692","https://openalex.org/W2055145999"],"abstract_inverted_index":{"UNLABELLED:":[0],"In":[1],"recent":[2],"years,":[3],"a":[4,105,122,140,164,168,193,249],"large":[5],"number":[6],"of":[7,12,18,24,35,51,65,176,202,229,236],"groups":[8],"studied":[9],"the":[10,22,25,66,152,234],"fate":[11],"human":[13,36,68,87,135,142,169,177,203,222],"stem":[14],"cells":[15,39,69,98,120,155,162,207],"in":[16,74,205],"livers":[17,50],"immunodeficient":[19],"animals.":[20],"However,":[21,97],"interpretation":[23],"results":[26,216],"is":[27,172],"quite":[28],"controversial.":[29],"We":[30,240],"transplanted":[31,67,212],"4":[32,221],"different":[33,227],"types":[34,225],"extrahepatic":[37],"precursor":[38,223],"(derived":[40],"from":[41,128,151,210],"cord":[42],"blood,":[43],"monocytes,":[44],"bone":[45],"marrow,":[46],"and":[47,89,108,115,166,232,255],"pancreas)":[48],"into":[49],"nonobese":[52],"diabetic/severe":[53],"combined":[54],"immunodeficiency":[55],"mice.":[56],"Human":[57],"hepatocytes":[58],"were":[59,93,217],"used":[60],"as":[61,192],"positive":[62,85],"controls.":[63],"Tracking":[64],"could":[70,147],"be":[71,148],"achieved":[72],"by":[73,156,174],"situ":[75],"hybridization":[76],"with":[77,81,99,219,231],"alu":[78],"probes.":[79],"Cells":[80],"alu-positive":[82,100],"nuclei":[83,101,204],"stained":[84],"for":[86,134,244,248],"albumin":[88],"glycogen.":[90],"Both":[91],"markers":[92],"negative":[94],"before":[95],"transplantation.":[96],"did":[102,109],"not":[103,110,167,182,243],"show":[104],"hepatocyte-like":[106,158],"morphology":[107],"express":[111],"cytochrome":[112],"P450":[113],"3A4,":[114],"this":[116],"suggests":[117],"that":[118,146,208],"these":[119,161],"represent":[121],"mixed":[123],"cell":[124,144,224],"type":[125,145],"possibly":[126,256],"resulting":[127],"partial":[129,253],"transdifferentiation.":[130],"Using":[131],"antibodies":[132],"specific":[133],"albumin,":[136],"we":[137,187,198],"also":[138],"observed":[139,199,241],"second":[141],"albumin-positive":[143],"clearly":[149],"distinguished":[150],"previously":[153],"described":[154],"its":[157],"morphology.":[159],"Surprisingly,":[160],"had":[163],"mouse":[165,206],"nucleus":[170],"which":[171],"explained":[173],"transdifferentiation":[175,245],"cells.":[178,213],"Although":[179],"it":[180],"has":[181],"yet":[183],"been":[184],"formally":[185],"proven,":[186],"suggest":[188],"horizontal":[189,257],"gene":[190,258],"transfer":[191],"likely":[194],"mechanism,":[195],"especially":[196],"because":[197],"small":[200],"fragments":[201],"originated":[209],"deteriorating":[211],"Qualitatively":[214],"similar":[215],"obtained":[218],"all":[220],"through":[226],"routes":[228],"administration":[230],"without":[233],"induction":[235],"liver":[237],"damage.":[238],"CONCLUSION:":[239],"evidence":[242],"but":[246],"instead":[247],"complex":[250],"situation":[251],"including":[252],"differentiation":[254],"transfer.":[259]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}