{"id":"https://openalex.org/W2024256466","doi":"https://doi.org/10.1016/s0531-5131(03)01686-8","title":"Mitochondrial alterations and a higher oxidative status in cultured fibroblast-like cells from senescence-accelerated mice","display_name":"Mitochondrial alterations and a higher oxidative status in cultured fibroblast-like cells from senescence-accelerated mice","publication_year":2003,"publication_date":"2003-12-23","ids":{"openalex":"https://openalex.org/W2024256466","doi":"https://doi.org/10.1016/s0531-5131(03)01686-8","mag":"2024256466"},"language":"en","primary_location":{"id":"doi:10.1016/s0531-5131(03)01686-8","doi":"https://doi.org/10.1016/s0531-5131(03)01686-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5131(03)01686-8","pdf_url":null,"source":{"id":"https://openalex.org/S172137629","display_name":"International Congress Series","issn_l":"0531-5131","issn":["0531-5131","1873-6157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Congress Series","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018908254","display_name":"Yoichi Chiba","orcid":"https://orcid.org/0000-0003-1417-8689","observed_orcids":["https://orcid.org/0000-0003-1417-8689"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoichi Chiba","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan","Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan","institution_ids":["https://openalex.org/I4210160234"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshinori Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Yamashita","raw_affiliation_strings":["Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan","Laboratory of Aging Study, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan","institution_ids":["https://openalex.org/I4210160234"]},{"raw_affiliation_string":"Laboratory of Aging Study, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051773020","display_name":"Kazunori Hirayoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Hirayoshi","raw_affiliation_strings":["Department of Ultrastructural Research, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ultrastructural Research, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103144469","display_name":"Masaki Ueno","orcid":"https://orcid.org/0000-0002-6592-3573","observed_orcids":["https://orcid.org/0000-0002-6592-3573"]},"institutions":[{"id":"https://openalex.org/I201933988","display_name":"Kagawa University","ror":"https://ror.org/04j7mzp05","country_code":"JP","type":"education","lineage":["https://openalex.org/I201933988"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Ueno","raw_affiliation_strings":["The Second Department of Pathology, Kagawa Medical University, Kagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Pathology, Kagawa Medical University, Kagawa, Japan","institution_ids":["https://openalex.org/I201933988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109336242","display_name":"Hiromi Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Fujisawa","raw_affiliation_strings":["Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111604471","display_name":"Takatoshi Matsushita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takatoshi Matsushita","raw_affiliation_strings":["Division of Technical Support, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Technical Support, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452149","display_name":"Kumiko Kogishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Kogishi","raw_affiliation_strings":["Division of Technical Support, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Technical Support, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067007089","display_name":"Ichiro Akiguchi","orcid":"https://orcid.org/0000-0003-2091-2720","observed_orcids":["https://orcid.org/0000-0003-2091-2720"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Akiguchi","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012393967","display_name":"Mamoru Satoh","orcid":"https://orcid.org/0000-0002-2165-3153","observed_orcids":["https://orcid.org/0000-0002-2165-3153"]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Satoh","raw_affiliation_strings":["Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan","institution_ids":["https://openalex.org/I4210160234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008058192","display_name":"Atsuyoshi Shimada","orcid":"https://orcid.org/0000-0002-1347-7022","observed_orcids":["https://orcid.org/0000-0002-1347-7022"]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuyoshi Shimada","raw_affiliation_strings":["Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan","institution_ids":["https://openalex.org/I4210160234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103534498","display_name":"Masanori Hosokawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Hosokawa","raw_affiliation_strings":["Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kamiya-cho, Kasugai, Aichi 480-0392, Japan","institution_ids":["https://openalex.org/I4210160234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018908254"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4210160234"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09218685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1260","issue":null,"first_page":"255","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senescence-accelerated-mouse","display_name":"senescence-accelerated mice","score":0.9580000042915344},{"id":"https://openalex.org/keywords/samr1","display_name":"SAMR1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7250000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mitochondrial-morphology","display_name":"mitochondrial morphology","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8500000238418579},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/mitochondrial-degeneration","display_name":"mitochondrial degeneration","score":0.6970000267028809},{"id":"https://openalex.org/keywords/mitochondrial-cristae","display_name":"mitochondrial cristae","score":0.5109999775886536},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7662567496299744},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6813384294509888},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6798854470252991},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6341904997825623},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.6279041767120361},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6269721388816833},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6172553300857544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5861812233924866},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5307427048683167},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.5108356475830078},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.49647361040115356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4783555865287781},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4340782165527344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3799889087677002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3521210849285126},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31812283396720886},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.23338067531585693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19532009959220886},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10963663458824158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09506779909133911}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0531-5131(03)01686-8","doi":"https://doi.org/10.1016/s0531-5131(03)01686-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5131(03)01686-8","pdf_url":null,"source":{"id":"https://openalex.org/S172137629","display_name":"International Congress Series","issn_l":"0531-5131","issn":["0531-5131","1873-6157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Congress Series","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4099999964237213,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1768247331","https://openalex.org/W2016486229","https://openalex.org/W2031400881","https://openalex.org/W2039305402","https://openalex.org/W2087607820","https://openalex.org/W2115562153","https://openalex.org/W2152700834"],"related_works":["https://openalex.org/W2791511901","https://openalex.org/W2059729414","https://openalex.org/W2082627181","https://openalex.org/W2339852853","https://openalex.org/W2162414118","https://openalex.org/W2394369094","https://openalex.org/W2037680056","https://openalex.org/W3138183563","https://openalex.org/W4211174191","https://openalex.org/W1947662605"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
