{"id":"https://openalex.org/W2024178355","doi":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","title":"Oncogene expression is modulated by recombinant human interferon-\u03b2 in human breast-cancer cells","display_name":"Oncogene expression is modulated by recombinant human interferon-\u03b2 in human breast-cancer cells","publication_year":1996,"publication_date":"1996-07-29","ids":{"openalex":"https://openalex.org/W2024178355","doi":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","mag":"2024178355","pmid":"https://pubmed.ncbi.nlm.nih.gov/8707422"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","doi":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819960729%2967%3A3%3C441%3A%3AAID-IJC21%3E3.0.CO%3B2-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111940441","display_name":"Gigliola Sica","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gigliola Sica","raw_affiliation_strings":["Institute of Histology and Embryology, Catholic University of the Sacred Heart, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033846239","display_name":"Cristiana Angelucci","orcid":"https://orcid.org/0000-0002-5177-6533","observed_orcids":["https://orcid.org/0000-0002-5177-6533"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristiana Angelucci","raw_affiliation_strings":["Institute of Histology and Embryology, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110234923","display_name":"Luca Marini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Marini","raw_affiliation_strings":["Institute of Histology and Embryology, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Histology and Embryology, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037065405","display_name":"Ferdinando Maria Milazzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferdinando Milazzo","raw_affiliation_strings":["\u201cCesare Serono\u201d Institute of Research, Via di Valle Caia 22, 00040 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cCesare Serono\u201d Institute of Research, Via di Valle Caia 22, 00040 Rome, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028241443","display_name":"S. Donini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvia Donini","raw_affiliation_strings":["\u201cCesare Serono\u201d Institute of Research, Via di Valle Caia 22, 00040 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u201cCesare Serono\u201d Institute of Research, Via di Valle Caia 22, 00040 Rome, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111940441"],"corresponding_institution_ids":["https://openalex.org/I103320735"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.3816,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58098244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"67","issue":"3","first_page":"441","last_page":"446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9480000138282776},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/oncoprotein-expression","display_name":"oncoprotein expression","score":0.847000002861023},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9940000176429749},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/zr-75-1-cells","display_name":"ZR-75-1 cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mda-mb-453-cells","display_name":"MDA-MB-453 cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6791136264801025},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6777931451797485},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6169049739837646},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6051545739173889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6035957336425781},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5859151482582092},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5549983382225037},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5544278025627136},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4750376045703888},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4517384171485901},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43094491958618164},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4138530492782593},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.4113411009311676},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.40504488348960876},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30404192209243774},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29581189155578613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2519540786743164},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.19836607575416565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12099218368530273}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","doi":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.0.co;2-9","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.3.co;2-y","doi":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.3.co;2-y","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.3.co;2-y","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819960729%2967%3A3%3C441%3A%3AAID-IJC21%3E3.0.CO%3B2-9","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:8707422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8707422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.3.co;2-y","doi":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.3.co;2-y","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0215(19960729)67:3<441::aid-ijc21>3.3.co;2-y","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291097-0215%2819960729%2967%3A3%3C441%3A%3AAID-IJC21%3E3.0.CO%3B2-9","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024178355.pdf","grobid_xml":"https://content.openalex.org/works/W2024178355.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1482175312","https://openalex.org/W1521909328","https://openalex.org/W1528036810","https://openalex.org/W1665239406","https://openalex.org/W1977125175","https://openalex.org/W1980983392","https://openalex.org/W1986567149","https://openalex.org/W1990602667","https://openalex.org/W1990632557","https://openalex.org/W2014296185","https://openalex.org/W2015770184","https://openalex.org/W2017941945","https://openalex.org/W2033856885","https://openalex.org/W2040676382","https://openalex.org/W2042006108","https://openalex.org/W2046804830","https://openalex.org/W2060546037","https://openalex.org/W2061126177","https://openalex.org/W2073379232","https://openalex.org/W2089336373","https://openalex.org/W2093501816","https://openalex.org/W2101572118","https://openalex.org/W2102131116","https://openalex.org/W2112549075","https://openalex.org/W2115576520","https://openalex.org/W2136548258","https://openalex.org/W2144284338","https://openalex.org/W2209641406","https://openalex.org/W2296627767","https://openalex.org/W2366808642","https://openalex.org/W2403593794","https://openalex.org/W2432664607","https://openalex.org/W2439512156"],"related_works":["https://openalex.org/W2439512156","https://openalex.org/W2073379232","https://openalex.org/W2432664607","https://openalex.org/W1967553714","https://openalex.org/W2023125797","https://openalex.org/W2408965471","https://openalex.org/W2061628667","https://openalex.org/W2056702424","https://openalex.org/W1977125175","https://openalex.org/W2889145473"],"abstract_inverted_index":{"The":[0,40,99,123],"effect":[1],"of":[2,32,36,43,51,83,101,120,125,149,152,170],"recombinant":[3,133],"human":[4,15,134],"interferon-beta":[5,135],"on":[6],"growth":[7],"and":[8,56,69,76,127],"oncoprotein":[9],"expression":[10,124],"was":[11,46,129,155],"investigated":[12],"in":[13,61,67,105,141],"several":[14],"breast-cancer":[16],"cell":[17,23,44,121],"lines":[18,24],"with":[19],"different":[20],"characteristics.":[21],"All":[22],"tested":[25],"were":[26],"sensitive":[27],"to":[28,108,117,175],"the":[29,33,102,118,138,167],"antiproliferative":[30],"action":[31],"drug,":[34],"regardless":[35],"their":[37],"estrogen":[38],"sensitivity.":[39],"maximal":[41],"inhibition":[42],"proliferation":[45],"seen":[47],"after":[48,73,80,132,160],"6":[49],"days":[50],"treatment.":[52],"In":[53],"estrogen-sensitive":[54],"CG-5":[55,142],"ZR-75-1":[57],"cells,":[58,64],"but":[59,92],"not":[60,90,114],"MDA-MB-453":[62],"estrogen-insensitive":[63],"a":[65],"reduction":[66,169],"c-myc":[68,128,153],"c-erbB2":[70,126,150],"oncoproteins":[71,106,171],"occurred":[72],"48-72":[74],"hr":[75,82],"became":[77],"more":[78],"pronounced":[79],"120-168":[81,161],"treatment,":[84,136],"suggesting":[85],"that":[86,110,166],"this":[87,111],"down-regulation":[88],"is":[89,93,113],"direct":[91],"mediated":[94],"by":[95],"undefined":[96],"molecular":[97],"mechanisms.":[98,177],"time-course":[100],"IFN-mediated":[103],"decrease":[104],"seems":[107],"indicate":[109],"event":[112],"strictly":[115],"related":[116],"IFN-regulation":[119],"proliferation.":[122],"also":[130],"analyzed,":[131],"at":[137],"mRNA":[139,154],"level":[140],"cells.":[143],"Surprisingly,":[144],"no":[145],"statistically":[146],"significant":[147],"variation":[148],"or":[151,159],"found":[156],"either":[157],"before":[158],"hr.":[162],"Thus,":[163],"we":[164],"surmise":[165],"observed":[168],"may":[172],"be":[173],"due":[174],"post-transcriptional":[176]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}