{"id":"https://openalex.org/W2024036818","doi":"https://doi.org/10.1586/14737140.3.3.367","title":"Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer","display_name":"Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2024036818","doi":"https://doi.org/10.1586/14737140.3.3.367","mag":"2024036818","pmid":"https://pubmed.ncbi.nlm.nih.gov/12820779"},"language":"en","primary_location":{"id":"doi:10.1586/14737140.3.3.367","doi":"https://doi.org/10.1586/14737140.3.3.367","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737140.3.3.367","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074000911","display_name":"Mazen Y. Khalil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090793","display_name":"Shadyside Hospital","ror":"https://ror.org/00b4wat71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090793","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mazen Y Khalil","raw_affiliation_strings":["Department of Medicine, University of Pittsburgh Medical Center, Shadyside, PA 15232, USA. khalilm@msx.upmc.edu","Department of Medicine, University of Pittsburgh Medical Center Shadyside, 5230 Centre Avenue, Pittsburgh, PA 15232, USA. khalilm@msx.upmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh Medical Center, Shadyside, PA 15232, USA. khalilm@msx.upmc.edu","institution_ids":["https://openalex.org/I4210090793","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Medicine, University of Pittsburgh Medical Center Shadyside, 5230 Centre Avenue, Pittsburgh, PA 15232, USA. khalilm@msx.upmc.edu","institution_ids":["https://openalex.org/I4210090793","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088286120","display_name":"Jennifer Rubin Grandis","orcid":"https://orcid.org/0000-0002-1013-8965","observed_orcids":["https://orcid.org/0000-0002-1013-8965"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer R Grandis","raw_affiliation_strings":["Department of Otolaryngology, University of Pittsburgh Medical Center, The Eye and Ear Institute, 203 Lothrop Street, Suite 500, Pittsburgh, PA 15213, USA. jgrandis@pitt.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Pittsburgh Medical Center, The Eye and Ear Institute, 203 Lothrop Street, Suite 500, Pittsburgh, PA 15213, USA. jgrandis@pitt.edu","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010399375","display_name":"Dong Moon Shin","orcid":"https://orcid.org/0000-0002-8245-4174","observed_orcids":["https://orcid.org/0000-0002-8245-4174"]},"institutions":[{"id":"https://openalex.org/I4210098814","display_name":"UPMC Health System","ror":"https://ror.org/011htkb76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong M Shin","raw_affiliation_strings":["Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, USA. shindm@msx.upmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, USA. shindm@msx.upmc.edu","institution_ids":["https://openalex.org/I4210098814","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3522,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.79584261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"3","first_page":"367","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9829999804496765},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8169999718666077},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.42899999022483826},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8528921604156494},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6530486941337585},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49834680557250977},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4743049144744873},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.45189619064331055},{"id":"https://openalex.org/C2908728163","wikidata":"https://www.wikidata.org/wiki/Q415271","display_name":"Human Epidermal Growth Factor Receptor 2","level":4,"score":0.4378279745578766},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42905017733573914},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4121479392051697},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3385929465293884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28072962164878845},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.18577000498771667}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/14737140.3.3.367","doi":"https://doi.org/10.1586/14737140.3.3.367","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737140.3.3.367","pdf_url":null,"source":{"id":"https://openalex.org/S93370067","display_name":"Expert Review of Anticancer Therapy","issn_l":"1473-7140","issn":["1473-7140","1744-8328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Anticancer Therapy","raw_type":"journal-article"},{"id":"pmid:12820779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12820779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of anticancer therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W26155307","https://openalex.org/W90292846","https://openalex.org/W101504470","https://openalex.org/W135877420","https://openalex.org/W141627170","https://openalex.org/W141806765","https://openalex.org/W1490790087","https://openalex.org/W1492692780","https://openalex.org/W1507805464","https://openalex.org/W1526030166","https://openalex.org/W1532588163","https://openalex.org/W1546210634","https://openalex.org/W1553189784","https://openalex.org/W1554880727","https://openalex.org/W1569865130","https://openalex.org/W1582315378","https://openalex.org/W1605429420","https://openalex.org/W1659692600","https://openalex.org/W1679497203","https://openalex.org/W1736865258","https://openalex.org/W1779286308","https://openalex.org/W1804903119","https://openalex.org/W1913061990","https://openalex.org/W1929145004","https://openalex.org/W1939364580","https://openalex.org/W1945415917","https://openalex.org/W1967726190","https://openalex.org/W1972004339","https://openalex.org/W1972169338","https://openalex.org/W1972474762","https://openalex.org/W1976806852","https://openalex.org/W1979145099","https://openalex.org/W1981608739","https://openalex.org/W1983104536","https://openalex.org/W1988561129","https://openalex.org/W1989055139","https://openalex.org/W1993373872","https://openalex.org/W1999585013","https://openalex.org/W2000957614","https://openalex.org/W2005204942","https://openalex.org/W2005496035","https://openalex.org/W2007030561","https://openalex.org/W2014530502","https://openalex.org/W2015394676","https://openalex.org/W2016008185","https://openalex.org/W2017091728","https://openalex.org/W2019995422","https://openalex.org/W2021568924","https://openalex.org/W2023447434","https://openalex.org/W2026175788","https://openalex.org/W2029548655","https://openalex.org/W2029667363","https://openalex.org/W2036363901","https://openalex.org/W2037491928","https://openalex.org/W2038443998","https://openalex.org/W2040264246","https://openalex.org/W2045508611","https://openalex.org/W2056780782","https://openalex.org/W2058156534","https://openalex.org/W2059048157","https://openalex.org/W2064047613","https://openalex.org/W2064973618","https://openalex.org/W2067172685","https://openalex.org/W2069637592","https://openalex.org/W2072218566","https://openalex.org/W2073464554","https://openalex.org/W2074518737","https://openalex.org/W2078342447","https://openalex.org/W2079366424","https://openalex.org/W2080299223","https://openalex.org/W2081625464","https://openalex.org/W2082601735","https://openalex.org/W2085141824","https://openalex.org/W2088658971","https://openalex.org/W2088716222","https://openalex.org/W2093222764","https://openalex.org/W2095483608","https://openalex.org/W2100960099","https://openalex.org/W2103174300","https://openalex.org/W2104036338","https://openalex.org/W2105516763","https://openalex.org/W2106764013","https://openalex.org/W2108523633","https://openalex.org/W2109823193","https://openalex.org/W2112522176","https://openalex.org/W2112964045","https://openalex.org/W2116398087","https://openalex.org/W2121997189","https://openalex.org/W2123284520","https://openalex.org/W2132750264","https://openalex.org/W2133453529","https://openalex.org/W2135422811","https://openalex.org/W2136861363","https://openalex.org/W2137622686","https://openalex.org/W2138899227","https://openalex.org/W2146441381","https://openalex.org/W2148505656","https://openalex.org/W2151220251","https://openalex.org/W2155022531","https://openalex.org/W2156875255","https://openalex.org/W2159506251","https://openalex.org/W2159542715","https://openalex.org/W2163402367","https://openalex.org/W2170517479","https://openalex.org/W2171685800","https://openalex.org/W2232770029","https://openalex.org/W2286614396","https://openalex.org/W2291334052","https://openalex.org/W2326413988","https://openalex.org/W2331056746","https://openalex.org/W2339422318","https://openalex.org/W2394588678","https://openalex.org/W2395521642","https://openalex.org/W2396242123","https://openalex.org/W2400430244","https://openalex.org/W2416808238","https://openalex.org/W2474195763","https://openalex.org/W4242286941","https://openalex.org/W4255169631"],"related_works":["https://openalex.org/W2152006092","https://openalex.org/W2066715163","https://openalex.org/W195048485","https://openalex.org/W1967330952","https://openalex.org/W2044926114","https://openalex.org/W1803620880","https://openalex.org/W2144315144","https://openalex.org/W2000480359","https://openalex.org/W2437757278","https://openalex.org/W2055994355"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,56,60,84,97,111,162,225,236,246],"epidermal":[2],"growth":[3],"factor":[4],"receptor":[5],"(EGFR)":[6],"in":[7,88,102,120,126,144,150,177,182,192,197,252],"epithelial":[8],"tumors,":[9,20],"including":[10,164],"head":[11],"and":[12,17,41,52,63,72,82,108,137,172,211,227,233,257],"neck,":[13],"lung,":[14],"breast,":[15],"colon":[16],"other":[18],"solid":[19],"has":[21],"frequently":[22],"been":[23,70,175,216],"correlated":[24],"with":[25,104,122,152,184,199,242],"poor":[26],"prognosis,":[27],"thus":[28],"stimulating":[29],"efforts":[30],"to":[31,78,141,218,222],"develop":[32],"new":[33],"cancer":[34],"therapies":[35],"that":[36],"target":[37],"EGFR.":[38],"Monoclonal":[39],"antibodies":[40,62,210],"tyrosine":[42,64,212],"kinase":[43,65,156,213],"inhibitors":[44,66,157,214],"specifically":[45],"targeting":[46,67,86,145,158],"EGFR":[47,68,205,248],"are":[48,75],"the":[49,80,159,223,254],"most":[50],"well-studied":[51],"hold":[53],"substantial":[54],"promise":[55],"success.":[57],"Several":[58],"compounds":[59,131,238],"monoclonal":[61,209],"have":[69,139,174,215],"studied":[71,176,191],"clinical":[73,178],"trials":[74],"now":[76],"underway":[77],"test":[79],"safety":[81],"efficacy":[83],"these":[85,98,112,237],"strategies":[87],"several":[89],"human":[90],"tumors.":[91],"This":[92],"review":[93],"will":[94],"address":[95],"each":[96],"agents":[99,250],"alone":[100,148,180],"or":[101,106,124,149,181,186],"combination":[103,121,151,183],"radiation":[105,123,185,228],"chemotherapy":[107,125,226],"highlight":[109],"some":[110],"promising":[113],"developments.":[114],"Cetuximab":[115],"(Erbitux)":[116],"is":[117,189],"being":[118,190],"evaluated":[119],"Phase":[127,194],"III":[128,195],"trials.":[129],"Other":[130],"such":[132],"as":[133],"h-R3,":[134],"ABX-EGF,":[135],"EMD-55900":[136],"ICR-62":[138],"proved":[140],"be":[142],"effective":[143],"malignant":[146],"cells":[147,221],"traditional":[153],"therapies.":[154],"Tyrosine":[155],"intracellular":[160],"domain":[161],"EGFR,":[163],"ZD-1839":[165,188],"(gefitinib,":[166],"Iressa),":[167],"OSI-774":[168],"(Erlotinib/Tarceva),":[169],"PD-153053,":[170],"PD-168393":[171],"CI-1033,":[173],"setting":[179],"chemotherapy.":[187],"a":[193],"trial":[196],"patients":[198],"advanced":[200],"non-small":[201],"cell":[202],"lung":[203],"cancer.":[204],"targeted":[206,249],"treatment":[207],"by":[208],"proven":[217],"sensitize":[219],"tumor":[220],"effects":[224],"therapy.":[229,244],"The":[230],"synergistic":[231],"activities":[232],"nonoverlapping":[234],"toxicities":[235],"allow":[239],"concomitant":[240],"administration":[241],"cytotoxic":[243],"Challenges":[245],"evaluating":[247],"exist":[251],"selecting":[253],"optimal":[255],"dosages":[256],"determining":[258],"long-term":[259],"toxicity.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}