{"id":"https://openalex.org/W2023988893","doi":"https://doi.org/10.1007/s10350-005-0171-0","title":"Mechanisms of Microsatellite Instability in Colorectal Cancer Patients in Different Age Groups","display_name":"Mechanisms of Microsatellite Instability in Colorectal Cancer Patients in Different Age Groups","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2023988893","doi":"https://doi.org/10.1007/s10350-005-0171-0","mag":"2023988893","pmid":"https://pubmed.ncbi.nlm.nih.gov/16374936"},"language":"en","primary_location":{"id":"doi:10.1007/s10350-005-0171-0","doi":"https://doi.org/10.1007/s10350-005-0171-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10350-005-0171-0","pdf_url":null,"source":{"id":"https://openalex.org/S170496595","display_name":"Diseases of the Colon & Rectum","issn_l":"0012-3706","issn":["0012-3706","1530-0358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Colon &amp; Rectum","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111566639","display_name":"Raymond Y. C. Yiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Yiu","raw_affiliation_strings":["Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota, USA","Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010081931","display_name":"Hongming Qiu","orcid":"https://orcid.org/0000-0002-2478-2401","observed_orcids":["https://orcid.org/0000-0002-2478-2401"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongming Qiu","raw_affiliation_strings":["Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101679452","display_name":"Suk-Hwan Lee","orcid":"https://orcid.org/0000-0001-6470-8620","observed_orcids":["https://orcid.org/0000-0001-6470-8620"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suk-Hwan Lee","raw_affiliation_strings":["Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010136395","display_name":"Julio Garc\u00eda\u2010Aguilar","orcid":"https://orcid.org/0000-0003-2451-0948","observed_orcids":["https://orcid.org/0000-0003-2451-0948"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio Garc\u00eda-Aguilar","raw_affiliation_strings":["Center for Colorectal Surgery, University of California San Francisco, 2330 Post Street, Suite 260, Box 0144, San Francisco, California, 94143-0144, e-mail","Department of Surgery, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Colorectal Surgery, University of California San Francisco, 2330 Post Street, Suite 260, Box 0144, San Francisco, California, 94143-0144, e-mail","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9557,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.90583406,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"48","issue":"11","first_page":"2061","last_page":"2069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9660000205039978},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/proximal-colon","display_name":"proximal colon","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mlh1-promoter-methylation","display_name":"MLH1 promoter methylation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.9697123765945435},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.8607414960861206},{"id":"https://openalex.org/C2779115348","wikidata":"https://www.wikidata.org/wiki/Q14911688","display_name":"MSH2","level":5,"score":0.7600392699241638},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7182101011276245},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.7144377827644348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5146666169166565},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.43211299180984497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4001062214374542},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38381069898605347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.378188818693161},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3602859377861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3568355143070221},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.34203866124153137},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3357142210006714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32022207975387573},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.30086392164230347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1859813928604126}],"mesh":[{"descriptor_ui":"D000070957","descriptor_name":"MutL Protein Homolog 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007420","descriptor_name":"Intestine, Large","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051718","descriptor_name":"MutS Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10350-005-0171-0","doi":"https://doi.org/10.1007/s10350-005-0171-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10350-005-0171-0","pdf_url":null,"source":{"id":"https://openalex.org/S170496595","display_name":"Diseases of the Colon & Rectum","issn_l":"0012-3706","issn":["0012-3706","1530-0358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the Colon &amp; Rectum","raw_type":"journal-article"},{"id":"pmid:16374936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16374936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases of the colon and rectum","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1499941079","https://openalex.org/W1544851750","https://openalex.org/W1583086124","https://openalex.org/W1856093855","https://openalex.org/W1907599506","https://openalex.org/W1978229269","https://openalex.org/W1982471925","https://openalex.org/W1983521494","https://openalex.org/W1986937402","https://openalex.org/W1989305101","https://openalex.org/W1990913299","https://openalex.org/W1991087105","https://openalex.org/W1994006697","https://openalex.org/W1994085819","https://openalex.org/W1994465394","https://openalex.org/W1995819860","https://openalex.org/W1998336855","https://openalex.org/W1999403773","https://openalex.org/W2003363961","https://openalex.org/W2012116455","https://openalex.org/W2016991845","https://openalex.org/W2018009295","https://openalex.org/W2024661574","https://openalex.org/W2027396428","https://openalex.org/W2027679130","https://openalex.org/W2037948309","https://openalex.org/W2040610490","https://openalex.org/W2040907303","https://openalex.org/W2043120427","https://openalex.org/W2044584637","https://openalex.org/W2045590775","https://openalex.org/W2048103082","https://openalex.org/W2069732891","https://openalex.org/W2077873083","https://openalex.org/W2078145123","https://openalex.org/W2080308138","https://openalex.org/W2082040301","https://openalex.org/W2085759774","https://openalex.org/W2087409829","https://openalex.org/W2089287416","https://openalex.org/W2089287779","https://openalex.org/W2107972234","https://openalex.org/W2119905136","https://openalex.org/W2126122220","https://openalex.org/W2126163659","https://openalex.org/W2127330908","https://openalex.org/W2128146359","https://openalex.org/W2129215293","https://openalex.org/W2134554242","https://openalex.org/W2154546296","https://openalex.org/W2322029840","https://openalex.org/W2329714940","https://openalex.org/W6689416344"],"related_works":["https://openalex.org/W2081549764","https://openalex.org/W9458506","https://openalex.org/W2089287416","https://openalex.org/W2003334760","https://openalex.org/W2049245075","https://openalex.org/W7100757887","https://openalex.org/W2605929286","https://openalex.org/W2028601156","https://openalex.org/W2113679793","https://openalex.org/W4399887491"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,83,105,150,263],"proportion":[2,151],"of":[3,17,33,56,63,82,101,107,136,152,154,181,208,267],"colorectal":[4,34,57,65,268],"cancers":[5,16,66,269],"located":[6,24],"proximal":[7,27,187,234,265],"to":[8,43],"the":[9,18,26,31,52,137,155,163,169,176,182,198,204,209,214,243,273],"splenic":[10],"flexure":[11],"increases":[12],"with":[13,36,189,219,248,272],"age.":[14],"Colorectal":[15],"microsatellite":[19,103,109,119,125,156,183,210,274],"instability":[20,91,157,184,211,275],"phenotype":[21,38,158,185,212],"are":[22],"preferentially":[23],"in":[25,39,54,162,168,175,192,213,242],"colon.":[28],"We":[29],"investigated":[30],"location":[32,235,257],"cancer":[35],"this":[37],"different":[40,46],"age":[41,69,195],"groups":[42,70],"determine":[44],"whether":[45],"molecular":[47],"mechanisms":[48],"could":[49],"account":[50],"for":[51,203],"changes":[53],"distribution":[55],"cancers.":[58],"METHODS:":[59],"A":[60],"representative":[61],"sample":[62],"230":[64],"from":[67,79],"three":[68,194],"(<45":[71],"years,":[72,74],"60-70":[73],">87":[75],"years)":[76],"was":[77,92,116,131,141,159],"selected":[78],"a":[80,99],"subset":[81],"Upper":[84],"Midwest":[85],"Oncology":[86],"Medical":[87],"Registries":[88],"database.":[89],"Microsatellite":[90],"determined":[93,132,142],"by":[94,133,143],"polymerase":[95,145],"chain":[96,146],"reaction":[97,147],"using":[98],"panel":[100],"five":[102],"markers.":[104],"presence":[106],"new":[108],"alleles":[110],"at":[111],"two":[112],"or":[113,223,230,237,252,259],"more":[114],"loci":[115],"scored":[117],"as":[118],"instability.":[120],"Tumors":[121,207],"were":[122,186,200,217,246],"otherwise":[123],"considered":[124],"stable.":[126],"MLH1":[127,138,220,226,277,280],"and":[128,172,233,255,279],"MSH2":[129,249],"expression":[130],"immunohistochemistry.":[134],"Methylation":[135],"gene":[139],"promotor":[140],"methylation-specific":[144],"assay.":[148],"RESULTS:":[149],"tumors":[153,180,191,241],"21":[160],"percent":[161,167,174],"young":[164,244],"group,":[165,171],"15":[166],"middle":[170],"33":[173],"old":[177,205],"group.":[178,206],"More":[179],"compared":[188],"microsatellite-stable":[190],"all":[193],"groups,":[196],"but":[197],"differences":[199],"significant":[201],"only":[202],"older":[215],"group":[216,245],"associated":[218,247,271],"inactivation":[221,250],"(24/29":[222],"83":[224],"percent),":[225,232,239],"promoter":[227,281],"methylation":[228],"(18/29":[229],"62":[231,260],"(25/29":[236],"86":[238],"while":[240],"(8/18":[251],"44":[253],"percent)":[254],"distal":[256],"(11/18":[258],"percent).":[261],"CONCLUSION:":[262],"age-related":[264],"shift":[266],"is":[270],"phenotype,":[276],"inactivation,":[278],"hypermethylation.":[282]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}