{"id":"https://openalex.org/W2023964353","doi":"https://doi.org/10.1159/000016363","title":"Tyrosine Kinases Open Lymphocyte Chloride Channels","display_name":"Tyrosine Kinases Open Lymphocyte Chloride Channels","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2023964353","doi":"https://doi.org/10.1159/000016363","mag":"2023964353","pmid":"https://pubmed.ncbi.nlm.nih.gov/11125210"},"language":"en","primary_location":{"id":"doi:10.1159/000016363","doi":"https://doi.org/10.1159/000016363","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000016363","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1159/000016363","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109220801","display_name":"Albrecht Lepple\u2010Wienhues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Albrecht Lepple-Wienhues","raw_affiliation_strings":["Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany. alepplew@uni-tuebingen.de","Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany. alepplew@uni-tuebingen.de","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075678380","display_name":"Ildik\u00f2 Szab\u00f3","orcid":"https://orcid.org/0000-0002-3637-3947","observed_orcids":["https://orcid.org/0000-0002-3637-3947","https://orcid.org/0000-0002-9844-7841"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ildik\u00f2 Szab\u00f2","raw_affiliation_strings":["Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028795920","display_name":"Ulrich Wieland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Wieland","raw_affiliation_strings":["Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026772751","display_name":"Luzia Heil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luzia Heil","raw_affiliation_strings":["Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041073789","display_name":"Erich Gulbins","orcid":"https://orcid.org/0000-0002-3117-1342","observed_orcids":["https://orcid.org/0000-0002-3117-1342"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erich Gulbins","raw_affiliation_strings":["Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084208566","display_name":"Florian J.W. Lang","orcid":"https://orcid.org/0000-0003-2962-1540","observed_orcids":["https://orcid.org/0000-0003-2962-1540"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Lang","raw_affiliation_strings":["Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology I, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8087733"],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":1.493,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80694186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"5-6","first_page":"307","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.34769999980926514,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lck","display_name":"Lck","score":0.8920000195503235},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.6570000052452087},{"id":"https://openalex.org/keywords/outwardly-rectifying-chloride-channel","display_name":"outwardly rectifying chloride channel","score":0.890999972820282},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/osmotic-swelling","display_name":"osmotic swelling","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6200000047683716},{"id":"https://openalex.org/keywords/chloride-conductance","display_name":"chloride conductance","score":0.7850000262260437},{"id":"https://openalex.org/keywords/osmoregulation","display_name":"osmoregulation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cell-volume-regulation","display_name":"cell volume regulation","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.7162420749664307},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5624687075614929},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5488291382789612},{"id":"https://openalex.org/C145822097","wikidata":"https://www.wikidata.org/wiki/Q106916978","display_name":"Chloride channel","level":2,"score":0.5198924541473389},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.487792044878006},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4691323935985565},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4585106670856476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4340288043022156},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4154050350189209},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3780165910720825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3363853394985199},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29952582716941833}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018118","descriptor_name":"Chloride Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000016363","doi":"https://doi.org/10.1159/000016363","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000016363","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:11125210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11125210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/1370926","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/1370926","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1159/000016363","doi":"https://doi.org/10.1159/000016363","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000016363","pdf_url":null,"source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W139123032","https://openalex.org/W1580762299","https://openalex.org/W1967456581","https://openalex.org/W1974852645","https://openalex.org/W1979423218","https://openalex.org/W1988031803","https://openalex.org/W1994409241","https://openalex.org/W2000492865","https://openalex.org/W2003724450","https://openalex.org/W2020142217","https://openalex.org/W2022681454","https://openalex.org/W2038701031","https://openalex.org/W2039864751","https://openalex.org/W2041466047","https://openalex.org/W2042217094","https://openalex.org/W2044145603","https://openalex.org/W2045986542","https://openalex.org/W2051329437","https://openalex.org/W2052531952","https://openalex.org/W2057474701","https://openalex.org/W2059813259","https://openalex.org/W2063002473","https://openalex.org/W2079302183","https://openalex.org/W2079720722","https://openalex.org/W2080443532","https://openalex.org/W2083232083","https://openalex.org/W2089914475","https://openalex.org/W2101626632","https://openalex.org/W2115375806","https://openalex.org/W2136018765","https://openalex.org/W2136782902","https://openalex.org/W2141989775","https://openalex.org/W2156986177","https://openalex.org/W2224021986","https://openalex.org/W2406075271","https://openalex.org/W2415551463","https://openalex.org/W2695194357"],"related_works":["https://openalex.org/W2042217094","https://openalex.org/W2001453486","https://openalex.org/W2101626632","https://openalex.org/W2032586838","https://openalex.org/W2126430478","https://openalex.org/W2047233384","https://openalex.org/W2005313327","https://openalex.org/W2013951269","https://openalex.org/W2154944652","https://openalex.org/W1995490018"],"abstract_inverted_index":{"Osmotic":[0,90],"swelling":[1,62],"of":[2,18,31,39,92,108,117,152,164],"lymphocytes":[3,45,77],"opens":[4],"outwardly":[5],"rectifying":[6],"Cl(-)":[7],"channels":[8,166],"(ORCC)":[9],"through":[10],"the":[11,32,98,153],"src-like":[12],"kinase":[13,22,100,155],"p56(lck).":[14],"The":[15],"central":[16],"role":[17,139],"this":[19],"tyrosine":[20,99,154],"protein":[21],"has":[23],"been":[24],"shown":[25],"by":[26,58,81,87,97,110],"genetic":[27],"and":[28,46,149],"pharmacologic":[29],"manipulation":[30],"enzyme.":[33],"Furthermore,":[34],"p56(lck)":[35,68,85,111,156],"activates":[36],"ORCC":[37,43,71,78,93,109],"independently":[38],"cell":[40,105],"volume":[41],"increase.":[42],"in":[44,72,103,126,167],"epithelial":[47],"cells":[48,141],"from":[49],"cystic":[50,127],"fibrosis":[51],"(CF)":[52],"patients":[53],"are":[54],"resistant":[55],"to":[56,131],"activation":[57,91],"cAMP.":[59],"However,":[60],"osmotic":[61,88],"as":[63,65],"well":[64],"intracellular":[66,83],"purified":[67],"can":[69,94],"activate":[70],"CF":[73],"lymphocytes.":[74,168],"In":[75,129],"non-CF":[76],"is":[79,123,157],"opened":[80],"either,":[82],"cAMP,":[84],"or":[86],"swelling.":[89],"be":[95],"blocked":[96],"inhibitor":[101],"lavendustin":[102],"both":[104],"types.":[106],"Regulation":[107],"thus":[112],"represents":[113],"an":[114,158],"alternative":[115],"pathway":[116],"stimulating":[118],"membrane":[119],"chloride":[120,165],"conductance":[121],"that":[122],"left":[124],"functional":[125],"fibrosis.":[128],"addition":[130],"osmoregulation":[132],"these":[133],"mechanisms":[134],"could":[135],"play":[136],"a":[137],"major":[138],"when":[140],"actively":[142],"change":[143],"their":[144],"volume,":[145],"i.e.":[146],"during":[147],"proliferation":[148],"apoptosis.":[150],"Activation":[151],"important":[159],"regulatory":[160],"step":[161],"for":[162],"opening":[163]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}