{"id":"https://openalex.org/W2023948557","doi":"https://doi.org/10.1182/blood-2009-03-209601","title":"A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma","display_name":"A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma","publication_year":2009,"publication_date":"2009-09-08","ids":{"openalex":"https://openalex.org/W2023948557","doi":"https://doi.org/10.1182/blood-2009-03-209601","mag":"2023948557","pmid":"https://pubmed.ncbi.nlm.nih.gov/19738032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2774542"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2009-03-209601","doi":"https://doi.org/10.1182/blood-2009-03-209601","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2009-03-209601","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2774542","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044526750","display_name":"Wendy Cozen","orcid":"https://orcid.org/0000-0003-3415-8247","observed_orcids":["https://orcid.org/0000-0003-3415-8247"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Cozen","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and","Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090789371","display_name":"Ann S. Hamilton","orcid":"https://orcid.org/0000-0001-5898-2308","observed_orcids":["https://orcid.org/0000-0001-5898-2308"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann S. Hamilton","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058548650","display_name":"Peng Zhao","orcid":"https://orcid.org/0000-0002-5479-899X","observed_orcids":["https://orcid.org/0000-0002-5479-899X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Zhao","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040972674","display_name":"Muhammad Towhid Salam","orcid":"https://orcid.org/0000-0002-3565-8916","observed_orcids":["https://orcid.org/0000-0002-3565-8916"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad T. Salam","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043249159","display_name":"Dennis Deapen","orcid":"https://orcid.org/0000-0002-0037-0277","observed_orcids":["https://orcid.org/0000-0002-0037-0277"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis M. Deapen","raw_affiliation_strings":["Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110349197","display_name":"Bharat N. Nathwani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat N. Nathwani","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112182874","display_name":"Lawrence Martin Weiss","orcid":"https://orcid.org/0000-0002-2356-535X","observed_orcids":["https://orcid.org/0000-0002-2356-535X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence M. Weiss","raw_affiliation_strings":["Department of Pathology, City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029377806","display_name":"Thomas M. Mack","orcid":"https://orcid.org/0000-0003-3775-3885","observed_orcids":["https://orcid.org/0000-0003-3775-3885"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Mack","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and","Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles;","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.5821,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.88444309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"114","issue":"19","first_page":"4014","last_page":"4020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.6700000166893005},{"id":"https://openalex.org/keywords/early-life-microbial-exposure","display_name":"early life microbial exposure","score":0.7059999704360962},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9399999976158142},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.9710000157356262},{"id":"https://openalex.org/keywords/appendectomy","display_name":"appendectomy","score":0.5220000147819519},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9869999885559082},{"id":"https://openalex.org/keywords/twin-discordance","display_name":"twin discordance","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cancer-etiology","display_name":"cancer etiology","score":0.5479999780654907},{"id":"https://openalex.org/keywords/protective-factors","display_name":"protective factors","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.6092907786369324},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5681495666503906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5426817536354065},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5339174866676331},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49985194206237793},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41067248582839966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763381540775299}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2009-03-209601","doi":"https://doi.org/10.1182/blood-2009-03-209601","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2009-03-209601","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2774542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2774542","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:19738032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19738032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2774542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2774542","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2882676462","display_name":null,"funder_award_id":"1R01CA58839","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6157114570","display_name":"Cytokine Polymorphisms and Hodgkin Lymphoma Risk","funder_award_id":"R03CA110836","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G633822576","display_name":"RISK FACTORS FOR YOUNG ADULT HODGKIN'S DISEASE IN TWINS","funder_award_id":"R03CA108336","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8829251156","display_name":"EPIDEMIOLOGY OF HD IN TWINS--INFECTIONS/T-CELL FUNCTION","funder_award_id":"5r01ca058839-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W17871461","https://openalex.org/W1527957830","https://openalex.org/W1582554697","https://openalex.org/W1585124497","https://openalex.org/W1947948867","https://openalex.org/W1972168709","https://openalex.org/W1985122351","https://openalex.org/W1986319272","https://openalex.org/W1988066089","https://openalex.org/W1993215668","https://openalex.org/W1996539502","https://openalex.org/W2004264592","https://openalex.org/W2019449022","https://openalex.org/W2025192174","https://openalex.org/W2032137791","https://openalex.org/W2033822810","https://openalex.org/W2037347206","https://openalex.org/W2041310846","https://openalex.org/W2060057102","https://openalex.org/W2074350983","https://openalex.org/W2074589325","https://openalex.org/W2076000688","https://openalex.org/W2082403106","https://openalex.org/W2085250121","https://openalex.org/W2086874336","https://openalex.org/W2128019846","https://openalex.org/W2132229447","https://openalex.org/W2136405679","https://openalex.org/W2137430034","https://openalex.org/W2138539334","https://openalex.org/W2141330149","https://openalex.org/W2142354113","https://openalex.org/W2142758173","https://openalex.org/W2145457899","https://openalex.org/W2146453846","https://openalex.org/W2150002636","https://openalex.org/W2151286180","https://openalex.org/W2155915629","https://openalex.org/W2159377933","https://openalex.org/W2163551998","https://openalex.org/W2185800594","https://openalex.org/W2284380051","https://openalex.org/W2309811352","https://openalex.org/W2327007930","https://openalex.org/W2339957067","https://openalex.org/W2410810535","https://openalex.org/W2517346518","https://openalex.org/W4254512323","https://openalex.org/W6634884468"],"related_works":["https://openalex.org/W2558727489","https://openalex.org/W3096472670","https://openalex.org/W3110240575","https://openalex.org/W2060057102","https://openalex.org/W2174681564","https://openalex.org/W2137430034","https://openalex.org/W2111816077","https://openalex.org/W2309981242","https://openalex.org/W2557248934","https://openalex.org/W2530244246"],"abstract_inverted_index":{"The":[0],"pattern":[1],"of":[2,61,89,96],"adolescent/young":[3],"adult":[4],"Hodgkin":[5],"lymphoma":[6],"(YAHL)":[7],"suggests":[8],"causation":[9],"by":[10],"a":[11,16,190],"relatively":[12,160],"late":[13],"infection":[14],"with":[15,94,165,205],"common":[17],"childhood":[18],"virus,":[19],"but":[20],"no":[21],"causal":[22],"virus":[23],"has":[24],"been":[25],"found.":[26],"Susceptibility":[27],"is":[28],"heritable":[29],"and":[30,66,159,208],"linked":[31],"to":[32,57,107,114,118,198,215],"lower":[33],"interleukin":[34],"12":[35],"(IL12)":[36],"levels,":[37],"which":[38],"can":[39],"also":[40],"result":[41],"from":[42,78],"fewer":[43],"fecal-oral":[44],"microbial":[45],"exposures":[46,59,167],"early":[47,195],"in":[48,122],"life.":[49],"We":[50],"studied":[51],"twin":[52,76],"pairs":[53,77,106],"discordant":[54],"for":[55,104,137,176,183,193],"YAHL":[56,90],"examine":[58],"capable":[60],"altering":[62],"the":[63,79,199],"IL12":[64],"response":[65],"T-helper":[67],"type":[68],"1":[69],"(Th1)-Th2":[70],"balance.":[71],"One":[72],"hundred":[73],"eighty-eight":[74],"YAHL-discordant":[75],"International":[80],"Twin":[81],"Study":[82],"returned":[83],"questionnaires":[84],"(70%":[85],"response).":[86],"Exposure":[87],"history":[88],"case-twins":[91],"was":[92],"compared":[93],"that":[95,202],"their":[97],"unaffected":[98],"control-twins":[99],"using":[100],"conditional":[101],"logistic":[102],"regression":[103],"matched":[105],"calculate":[108],"odds":[109],"ratios":[110],"(ORs).":[111],"Behaviors":[112],"likely":[113],"produce":[115],"oral":[116,166,196],"exposure":[117,197],"microbes":[119],"conveyed":[120],"decreases":[121],"risk":[123],"(univariable":[124],"OR":[125],"range":[126],"=":[127,130,140,143,147,150,154,157,169,172],"0.2-0.5,":[128],"P":[129,142,149,156,171],".003-.11).":[131],"Significant":[132],"adjusted":[133],"ORs":[134],"were":[135,179],"seen":[136],"appendectomy":[138],"(OR":[139,146,153,168],"4.3,":[141],".001),":[144],"eczema":[145],"4.2,":[148],".025),":[151],"smoking":[152],"2.2,":[155],".054),":[158],"more":[161],"frequent":[162],"behaviors":[163],"associated":[164,204],"0.1;":[170],".004).":[173],"Kappa":[174],"statistics":[175],"intrapair":[177],"agreement":[178],"higher":[180],"than":[181],"0.8":[182],"each":[184],"significant":[185],"finding.":[186],"Our":[187],"observations":[188],"support":[189],"protective":[191],"role":[192],"increased":[194,206],"microbiome,":[200],"suggesting":[201],"factors":[203],"Th2":[207],"decreased":[209],"Th1":[210],"cytokines":[211],"are":[212],"etiologically":[213],"relevant":[214],"YAHL.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}