{"id":"https://openalex.org/W2023947408","doi":"https://doi.org/10.1152/ajpcell.00099.2003","title":"Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress","display_name":"Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2023947408","doi":"https://doi.org/10.1152/ajpcell.00099.2003","mag":"2023947408","pmid":"https://pubmed.ncbi.nlm.nih.gov/12878488"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00099.2003","doi":"https://doi.org/10.1152/ajpcell.00099.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00099.2003","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000819682","display_name":"Silvia Muro","orcid":"https://orcid.org/0000-0003-1900-352X","observed_orcids":["https://orcid.org/0000-0003-1900-352X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia Muro","raw_affiliation_strings":["Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan/6068, 3620 Hamilton Walk, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Environmental Medicine, University of Pennsylvania School of Medicine, 1 John Morgan/6068, 3620 Hamilton Walk, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114040622","display_name":"Xiumin Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiumin Cui","raw_affiliation_strings":["","Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004856854","display_name":"Christine Gajewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Gajewski","raw_affiliation_strings":["","Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057682225","display_name":"Juan-Carlos Murciano","orcid":"https://orcid.org/0000-0002-4894-046X","observed_orcids":["https://orcid.org/0000-0002-4894-046X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan-Carlos Murciano","raw_affiliation_strings":["","Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022924802","display_name":"Vladimir R. Muzykantov","orcid":"https://orcid.org/0000-0001-6648-1204","observed_orcids":["https://orcid.org/0000-0001-6648-1204"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir R. Muzykantov","raw_affiliation_strings":["","Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082867899","display_name":"Michael H. Koval","orcid":"https://orcid.org/0000-0002-5422-5614","observed_orcids":["https://orcid.org/0000-0002-5422-5614"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Koval","raw_affiliation_strings":["","Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institute for Environmental Medicine and Departments of Pharmacology and Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":3.0464,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.90884261,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"285","issue":"5","first_page":"C1339","last_page":"C1347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7630000114440918},{"id":"https://openalex.org/keywords/intracellular-trafficking","display_name":"intracellular trafficking","score":0.7540000081062317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6389999985694885},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5609999895095825},{"id":"https://openalex.org/keywords/antibody-nanoparticle-conjugates","display_name":"antibody-nanoparticle conjugates","score":0.6959999799728394},{"id":"https://openalex.org/keywords/early-endosomes","display_name":"early endosomes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.890999972820282},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.996999979019165},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9610000252723694},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2779363559","wikidata":"https://www.wikidata.org/wiki/Q2506092","display_name":"Nocodazole","level":4,"score":0.6851429343223572},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.6384454965591431},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5728532075881958},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.5662963390350342},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5356957316398621},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5236698985099792},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5100113153457642},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4863756000995636},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.4643784761428833},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.41879695653915405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2806849181652069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2717089354991913},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.18975412845611572},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15450575947761536},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.11119753122329712}],"mesh":[{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.00099.2003","doi":"https://doi.org/10.1152/ajpcell.00099.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00099.2003","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:12878488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12878488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1623331570","display_name":null,"funder_award_id":"P01 HL 19737-26","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2939536134","display_name":"Cellular and molecular biology of lung surfactant","funder_award_id":"P01HL019737","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6677581136","display_name":"SCOR IN ACUTE LUNG INJURY","funder_award_id":"P50HL060290","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8824799604","display_name":"CONTROL OF CONNEXIN TRANSPORT AND ASSEMBLY","funder_award_id":"R01GM061012","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W19682556","https://openalex.org/W84645276","https://openalex.org/W206142983","https://openalex.org/W1488956834","https://openalex.org/W1551446381","https://openalex.org/W1578438134","https://openalex.org/W1856960941","https://openalex.org/W1875918201","https://openalex.org/W1946178771","https://openalex.org/W1966286149","https://openalex.org/W1967121463","https://openalex.org/W1975017859","https://openalex.org/W1975365119","https://openalex.org/W1985048358","https://openalex.org/W1991001058","https://openalex.org/W1994723563","https://openalex.org/W2003081532","https://openalex.org/W2009328749","https://openalex.org/W2011001489","https://openalex.org/W2013685525","https://openalex.org/W2014013678","https://openalex.org/W2020970293","https://openalex.org/W2023409962","https://openalex.org/W2034373812","https://openalex.org/W2039097438","https://openalex.org/W2050286820","https://openalex.org/W2058693442","https://openalex.org/W2062993109","https://openalex.org/W2064061284","https://openalex.org/W2066503447","https://openalex.org/W2072251818","https://openalex.org/W2074738467","https://openalex.org/W2075902865","https://openalex.org/W2079793032","https://openalex.org/W2081252914","https://openalex.org/W2087020662","https://openalex.org/W2088046959","https://openalex.org/W2088812802","https://openalex.org/W2089475265","https://openalex.org/W2090192485","https://openalex.org/W2093830420","https://openalex.org/W2105502651","https://openalex.org/W2106696513","https://openalex.org/W2107914421","https://openalex.org/W2114098292","https://openalex.org/W2152232523","https://openalex.org/W2155777849","https://openalex.org/W2156357692","https://openalex.org/W2184443404","https://openalex.org/W2189316303","https://openalex.org/W2237382470","https://openalex.org/W2281186437","https://openalex.org/W2397572162","https://openalex.org/W4231136244"],"related_works":["https://openalex.org/W2104030739","https://openalex.org/W2137452283","https://openalex.org/W2088128140","https://openalex.org/W2047053259","https://openalex.org/W1990556507","https://openalex.org/W2033048770","https://openalex.org/W1984062741","https://openalex.org/W2155785002","https://openalex.org/W2013800305","https://openalex.org/W2058693442"],"abstract_inverted_index":{"Nanotechnologies":[0],"promise":[1],"new":[2],"means":[3],"for":[4,12,70,147,182,196],"drug":[5],"delivery.":[6],"ICAM-1":[7,32],"is":[8],"a":[9,64,194],"good":[10],"target":[11],"vascular":[13,200],"immunotargeting":[14],"of":[15,87,114,128,159,166,185,198],"nanoparticles":[16,35,60,119,135,178],"to":[17,34,84,111,116,143,188],"the":[18,99,126,157,164,170],"perturbed":[19],"endothelium,":[20],"although":[21],"endothelial":[22,139,189],"cells":[23,41,140,190],"do":[24],"not":[25,49,124],"internalize":[26],"monomeric":[27],"anti-ICAM-1":[28],"antibodies.":[29],"However,":[30],"coupling":[31],"antibodies":[33],"creates":[36],"multivalent":[37],"ligands":[38],"that":[39,47,57],"enter":[40],"via":[42],"an":[43,71],"amiloride-sensitive":[44],"endocytic":[45],"pathway":[46,173],"does":[48],"require":[50],"clathrin":[51],"or":[52,131],"caveolin.":[53],"Fluorescence":[54],"microscopy":[55],"revealed":[56],"internalized":[58,176],"anti-ICAM":[59,96,108,118,177],"are":[61],"retained":[62],"in":[63,67],"stable":[65],"form":[66],"early":[68],"endosomes":[69],"unusually":[72],"long":[73],"time":[74],"(1-2":[75],"h)":[76],"and":[77,154,191],"subsequently":[78],"were":[79,136,141],"degraded":[80],"following":[81],"slow":[82],"transport":[83],"lysosomes.":[85,112],"Inhibition":[86],"lysosome":[88],"acidification":[89],"by":[90,106,162,175],"chloroquine":[91],"delayed":[92,104],"degradation":[93,105],"without":[94],"affecting":[95],"trafficking.":[97,132],"Also,":[98],"microtubule":[100],"disrupting":[101],"agent":[102],"nocodazole":[103,155],"inhibiting":[107],"nanoparticle":[109,129,151],"trafficking":[110,172],"Addition":[113],"catalase":[115],"create":[117],"with":[120],"antioxidant":[121,160],"activity":[122],"did":[123],"affect":[125],"mechanisms":[127],"uptake":[130],"Intracellular":[133],"anti-ICAM/catalase":[134,167],"active,":[137],"because":[138],"resistant":[142],"H2O2-induced":[144],"oxidative":[145,201],"injury":[146],"1-2":[148],"h":[149],"after":[150],"uptake.":[152],"Chloroquine":[153],"increased":[156],"duration":[158],"protection":[161],"decreasing":[163],"extent":[165],"degradation.":[168],"Therefore,":[169],"unique":[171],"followed":[174],"seems":[179],"well":[180],"suited":[181],"targeted":[183],"delivery":[184],"therapeutic":[186],"enzymes":[187],"may":[192],"provide":[193],"basis":[195],"treatment":[197],"acute":[199],"stress.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}