{"id":"https://openalex.org/W2023937509","doi":"https://doi.org/10.1165/rcmb.2013-0294oc","title":"Gata5 Deficiency Causes Airway Constrictor Hyperresponsiveness in Mice","display_name":"Gata5 Deficiency Causes Airway Constrictor Hyperresponsiveness in Mice","publication_year":2013,"publication_date":"2013-11-07","ids":{"openalex":"https://openalex.org/W2023937509","doi":"https://doi.org/10.1165/rcmb.2013-0294oc","mag":"2023937509","pmid":"https://pubmed.ncbi.nlm.nih.gov/24199649","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4068924"},"language":"en","primary_location":{"id":"doi:10.1165/rcmb.2013-0294oc","doi":"https://doi.org/10.1165/rcmb.2013-0294oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2013-0294oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4068924","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bohao Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bohao Chen","raw_affiliation_strings":["Department of Medicine and","1 Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]},{"raw_affiliation_string":"1 Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057559856","display_name":"Tamson V. Moore","orcid":"https://orcid.org/0000-0003-3770-3503","observed_orcids":["https://orcid.org/0000-0003-3770-3503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamson V. Moore","raw_affiliation_strings":["Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenping Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenping Li","raw_affiliation_strings":["Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088420409","display_name":"Anne I. Sperling","orcid":"https://orcid.org/0000-0002-4265-9212","observed_orcids":["https://orcid.org/0000-0002-4265-9212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne I. Sperling","raw_affiliation_strings":["Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439753","display_name":"Chunling Zhang","orcid":"https://orcid.org/0000-0003-2752-1028","observed_orcids":["https://orcid.org/0000-0003-2752-1028"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunling Zhang","raw_affiliation_strings":["Center for Research Informatics, University of Chicago, Chicago, Illinois; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics, University of Chicago, Chicago, Illinois; and","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006838633","display_name":"Jorge Andrade","orcid":"https://orcid.org/0000-0003-3210-2186","observed_orcids":["https://orcid.org/0000-0003-3210-2186"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Andrade","raw_affiliation_strings":["Center for Research Informatics, University of Chicago, Chicago, Illinois; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics, University of Chicago, Chicago, Illinois; and","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alex Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Rodriguez","raw_affiliation_strings":["Center for Research Informatics, University of Chicago, Chicago, Illinois; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics, University of Chicago, Chicago, Illinois; and","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004793396","display_name":"Neil Bahroos","orcid":"https://orcid.org/0000-0002-6522-1213","observed_orcids":["https://orcid.org/0000-0002-6522-1213"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Bahroos","raw_affiliation_strings":["Center for Research Informatics, University of Chicago, Chicago, Illinois; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research Informatics, University of Chicago, Chicago, Illinois; and","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065670232","display_name":"Edward E. Morrisey","orcid":"https://orcid.org/0000-0001-5785-1939","observed_orcids":["https://orcid.org/0000-0001-5785-1939"]},"institutions":[{"id":"https://openalex.org/I4210147155","display_name":"Pediatrics and Genetics","ror":"https://ror.org/03t432d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward E. Morrisey","raw_affiliation_strings":["Departments of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and","institution_ids":["https://openalex.org/I4210147155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082923331","display_name":"Peter J. Gruber","orcid":"https://orcid.org/0000-0002-7356-905X","observed_orcids":["https://orcid.org/0000-0002-7356-905X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Gruber","raw_affiliation_strings":["Surgery, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030124621","display_name":"Julian Solway","orcid":"https://orcid.org/0000-0002-0898-8530","observed_orcids":["https://orcid.org/0000-0002-0898-8530"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julian Solway","raw_affiliation_strings":["Department of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030124621"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2402,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.64520822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"50","issue":"4","first_page":"787","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gata5","display_name":"GATA5","score":0.9929999709129333},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8029999732971191},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.9549999833106995},{"id":"https://openalex.org/keywords/experimental-asthma","display_name":"experimental asthma","score":0.6909999847412109},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.9290000200271606},{"id":"https://openalex.org/keywords/goblet-cell-metaplasia","display_name":"goblet cell metaplasia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.546999990940094},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.843999981880188},{"id":"https://openalex.org/keywords/bronchial-epithelium","display_name":"bronchial epithelium","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C3019828301","wikidata":"https://www.wikidata.org/wiki/Q3801533","display_name":"Airway hyperresponsiveness","level":3,"score":0.8583906292915344},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.6191724538803101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5012884140014648},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3704444468021393},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.07527673244476318}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016084","descriptor_name":"Bronchoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016535","descriptor_name":"Bronchial Hyperreactivity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020397","descriptor_name":"Goblet Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D050992","descriptor_name":"GATA5 Transcription Factor","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D050992","descriptor_name":"GATA5 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1165/rcmb.2013-0294oc","doi":"https://doi.org/10.1165/rcmb.2013-0294oc","is_oa":false,"landing_page_url":"https://doi.org/10.1165/rcmb.2013-0294oc","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4068924","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4068924","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},{"id":"pmid:24199649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24199649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4068924","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4068924","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Respir Cell Mol Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1292986075","display_name":"The Role of GATA6 in Lung Development","funder_award_id":"R01HL064632","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2143359991","display_name":"SCOR in Cellular and Molecular Mechanisms of Asthma","funder_award_id":"P50HL056399","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3733707689","display_name":"Re-Engineering Translational Research at the University of Chicago","funder_award_id":"UL1TR000430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4902618043","display_name":"Airway inflammation and HLA-G in asthma","funder_award_id":"U19AI095230","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5868881864","display_name":"Multidisciplinary Research Training in Asthma Genetics & Genomics","funder_award_id":"K12HL090003","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G88826057","display_name":"Epigenic Regulation of Lung Progenitor Repair and Regeneration","funder_award_id":"U01HL110942","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000907409","display_name":"Interdisciplinary Training Program in Immunology","funder_award_id":"T32AI007090","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1577509897","https://openalex.org/W1972613882","https://openalex.org/W1976355188","https://openalex.org/W1977370347","https://openalex.org/W1981728382","https://openalex.org/W2003370420","https://openalex.org/W2008233106","https://openalex.org/W2027163151","https://openalex.org/W2034968148","https://openalex.org/W2046609531","https://openalex.org/W2063014521","https://openalex.org/W2063816440","https://openalex.org/W2088126954","https://openalex.org/W2111942445","https://openalex.org/W2114352556","https://openalex.org/W2118306607","https://openalex.org/W2124554987","https://openalex.org/W2124566107","https://openalex.org/W2125805192","https://openalex.org/W2130006532","https://openalex.org/W2137295747","https://openalex.org/W2138521680","https://openalex.org/W2140411489","https://openalex.org/W2163279941","https://openalex.org/W2165933222","https://openalex.org/W2170645885","https://openalex.org/W2186357519","https://openalex.org/W2733058066"],"related_works":["https://openalex.org/W2170690637","https://openalex.org/W2141907963","https://openalex.org/W2072376737","https://openalex.org/W2066266627","https://openalex.org/W2017212450","https://openalex.org/W1889501789","https://openalex.org/W2081940646","https://openalex.org/W7100491655","https://openalex.org/W2152468431","https://openalex.org/W2140686309"],"abstract_inverted_index":{"Gata5":[0,20,86,164,233],"is":[1,13,205],"a":[2],"transcription":[3],"factor":[4],"expressed":[5],"in":[6,43,67,82,96,108,128,140,150,170,197,239],"the":[7,33,68,91,123,151,159],"lung,":[8],"but":[9,100],"its":[10,174],"physiological":[11],"role":[12],"unknown.":[14],"To":[15],"test":[16],"whether":[17],"and":[18,29,46,56,131,134,167,172,199,203,213,244],"how":[19],"regulates":[21,165],"airway":[22,37,51,63,182],"constrictor":[23,38,64,79],"responsiveness,":[24],"we":[25],"studied":[26],"Gata5(-/-),":[27],"Gata5(+/-),":[28],"wild-type":[30],"mice":[31,44,60,74,110,179],"on":[32],"C57BL/6J":[34],"background.":[35],"Cholinergic":[36],"responsiveness":[39,80],"was":[40,105,122],"assessed":[41],"invasively":[42],"without":[45],"with":[47],"induction":[48],"of":[49,70,93,153],"allergic":[50],"inflammation":[52],"through":[53],"ovalbumin":[54],"sensitization":[55,212],"aerosol":[57],"exposure.":[58],"Gata5-deficient":[59,73,129,154,178,216],"displayed":[61],"native":[62,198],"hyperresponsiveness":[65],"(AHR)":[66],"absence":[69],"allergen-induced":[71],"inflammation.":[72],"retained":[75],"their":[76],"relatively":[77],"greater":[78],"even":[81],"ovalbumin-induced":[83],"experimental":[84,200],"asthma.":[85],"deficiency":[87,234],"did":[88],"not":[89],"alter":[90],"distribution":[92],"cell":[94,208],"types":[95],"bronchoalveolar":[97],"lavage":[98],"fluid,":[99],"bronchial":[101],"epithelial":[102],"mucus":[103],"metaplasia":[104,209],"more":[106],"prominent":[107],"Gata5(-/-)":[109,141],"after":[111,210],"allergen":[112,211],"challenge.":[113,214],"Gene":[114],"expression":[115,139,169],"profiles":[116],"revealed":[117,146],"that":[118,163,173,184,187,221,232],"apolipoprotein":[119],"E":[120],"(apoE)":[121],"fifth":[124],"most":[125],"down-regulated":[126],"transcript":[127],"lungs,":[130],"quantitative":[132],"RT-PCR":[133,144],"immunostaining":[135],"confirmed":[136],"reduced":[137],"apoE":[138,166,243],"mice.":[142,155,227],"Quantitative":[143],"also":[145,218],"increased":[147],"IL-13":[148,168,246],"mRNA":[149],"lungs":[152],"These":[156],"findings":[157],"for":[158,190,225],"first":[160],"time":[161],"show":[162],"vivo":[171],"deletion":[175],"causes":[176],"AHR.":[177],"exhibit":[180,194],"an":[181],"phenotype":[183,217],"closely":[185],"resembles":[186],"previously":[188,223],"reported":[189,224],"apoE(-/-)":[191],"mice:":[192],"both":[193],"cholinergic":[195],"AHR":[196],"asthma":[201],"states,":[202],"there":[204],"excessive":[206],"goblet":[207],"The":[215],"shares":[219],"features":[220],"were":[222],"IL-13-treated":[226],"Together,":[228],"these":[229],"results":[230],"indicate":[231],"induces":[235],"AHR,":[236],"at":[237],"least":[238],"part,":[240],"by":[241],"blunting":[242],"increasing":[245],"expression.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}