{"id":"https://openalex.org/W2023911414","doi":"https://doi.org/10.1021/bp00012a004","title":"Metabolic Activity Control of the L \u2010Lysine Fermentation by Restrained Growth Fed\u2010Batch Strategies","display_name":"Metabolic Activity Control of the L \u2010Lysine Fermentation by Restrained Growth Fed\u2010Batch Strategies","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2023911414","doi":"https://doi.org/10.1021/bp00012a004","mag":"2023911414"},"language":"en","primary_location":{"id":"doi:10.1021/bp00012a004","doi":"https://doi.org/10.1021/bp00012a004","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp00012a004","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert D Kiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D Kiss","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009763658"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":1.0013,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.73353046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"6","first_page":"501","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10864","display_name":"Fluid Dynamics and Mixing","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-lysine-production","display_name":"L-lysine production","score":0.8970000147819519},{"id":"https://openalex.org/keywords/corynebacterium-glutamicum","display_name":"Corynebacterium glutamicum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fed-batch-fermentation","display_name":"fed-batch fermentation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/respiratory-measurement","display_name":"respiratory measurement","score":0.5070000290870667},{"id":"https://openalex.org/keywords/feed-rate-control","display_name":"feed rate control","score":0.8949999809265137},{"id":"https://openalex.org/keywords/fermentation-yield","display_name":"fermentation yield","score":0.7860000133514404},{"id":"https://openalex.org/keywords/volumetric-productivity","display_name":"volumetric productivity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/online-monitoring","display_name":"online monitoring","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2776260651","wikidata":"https://www.wikidata.org/wiki/Q292314","display_name":"Corynebacterium glutamicum","level":3,"score":0.8384492993354797},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.8073248267173767},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.6676982641220093},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.6242031455039978},{"id":"https://openalex.org/C204983608","wikidata":"https://www.wikidata.org/wiki/Q2111958","display_name":"Productivity","level":2,"score":0.5617276430130005},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5394936203956604},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5196234583854675},{"id":"https://openalex.org/C167431671","wikidata":"https://www.wikidata.org/wiki/Q372004","display_name":"Fed-batch culture","level":3,"score":0.4498514235019684},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4015030860900879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3726503252983093},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.34927889704704285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3381953835487366},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.13166752457618713},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.07244497537612915},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/bp00012a004","doi":"https://doi.org/10.1021/bp00012a004","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bp00012a004","pdf_url":null,"source":{"id":"https://openalex.org/S186451451","display_name":"Biotechnology Progress","issn_l":"1520-6033","issn":["1520-6033","8756-7938"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Progress","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W624371979","https://openalex.org/W649690700","https://openalex.org/W1562172978","https://openalex.org/W1765575636","https://openalex.org/W1965111473","https://openalex.org/W1978753590","https://openalex.org/W1981669102","https://openalex.org/W1997200321","https://openalex.org/W2004429617","https://openalex.org/W2009802111","https://openalex.org/W2054343650","https://openalex.org/W2074978059","https://openalex.org/W2077959559","https://openalex.org/W2078804864","https://openalex.org/W2082856914","https://openalex.org/W2091589314","https://openalex.org/W2097642432","https://openalex.org/W2118312283","https://openalex.org/W2132510800","https://openalex.org/W2305086889","https://openalex.org/W2328932834","https://openalex.org/W2620703625"],"related_works":["https://openalex.org/W1997200321","https://openalex.org/W2149006522","https://openalex.org/W2062607982","https://openalex.org/W2043529555","https://openalex.org/W1981669102","https://openalex.org/W2081527573","https://openalex.org/W2037766217","https://openalex.org/W3194363408","https://openalex.org/W2078804864","https://openalex.org/W2385555967"],"abstract_inverted_index":{"Abstract":[0],"Batch":[1],"and":[2,18,32,45,85,99,120],"continuous":[3],"culture":[4],"experiments":[5],"were":[6,77,93],"conducted":[7],"with":[8],"the":[9,23,54,82,88,97,114],"L\u2010lysine":[10,30],"producer":[11],"Corynebacterium":[12],"glutamicum":[13],"to":[14,139],"characterize":[15],"fermentation":[16,41,83,89,116],"yields":[17],"rates,":[19],"as":[20,22,64],"well":[21],"relationship":[24],"between":[25],"biomass":[26],"catalytic":[27],"activity":[28,67],"toward":[29],"production":[31],"online":[33],"respiratory":[34,62],"measurements.":[35],"Experimental":[36],"correlations":[37],"suggested":[38],"that":[39,126],"improved":[40],"performance":[42],"(yield,":[43],"productivity,":[44,119],"titer)":[46],"could":[47],"be":[48,131],"achieved":[49],"through":[50],"fed\u2010batch":[51],"cultivation":[52],"of":[53,58,81,87,135],"organism":[55],"under":[56],"conditions":[57],"restrained":[59],"growth,":[60],"utilizing":[61],"measurements":[63],"a":[65],"metabolic":[66],"indicator":[68],"for":[69,79,105],"feed":[70],"rate":[71],"control.":[72],"Two":[73],"different":[74],"control":[75,129],"schemes":[76],"developed":[78],"maximization":[80,86],"yield":[84,98],"productivity.":[90],"Both":[91],"strategies":[92],"successful":[94],"in":[95,110,113],"maintaining":[96],"specific":[100],"productivity":[101],"at":[102],"high":[103],"levels":[104],"extended":[106],"times,":[107],"thus":[108,124],"resulting":[109],"significant":[111],"improvements":[112],"overall":[115],"yield,":[117],"volumetric":[118],"titer.":[121],"It":[122],"was":[123],"demonstrated":[125],"proper":[127],"environmental":[128],"can":[130],"an":[132],"effective":[133],"means":[134],"manipulating":[136],"microbial":[137],"metabolism":[138],"favor":[140],"metabolite":[141],"overproduction.":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
