{"id":"https://openalex.org/W2023902879","doi":"https://doi.org/10.1164/ajrccm.152.2.7633700","title":"Regional Control of Venous Return: Liver Blood Flow","display_name":"Regional Control of Venous Return: Liver Blood Flow","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2023902879","doi":"https://doi.org/10.1164/ajrccm.152.2.7633700","mag":"2023902879","pmid":"https://pubmed.ncbi.nlm.nih.gov/7633700"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.152.2.7633700","doi":"https://doi.org/10.1164/ajrccm.152.2.7633700","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.152.2.7633700","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104490190","display_name":"Nicola Brienza","orcid":"https://orcid.org/0000-0002-7582-3189","observed_orcids":["https://orcid.org/0000-0002-7582-3189"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Brienza","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075122815","display_name":"Takao Ayuse","orcid":"https://orcid.org/0000-0002-6202-1312","observed_orcids":["https://orcid.org/0000-0002-6202-1312","https://orcid.org/0000-0003-2326-6816"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Ayuse","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050022583","display_name":"Christopher Paul O'Donnell","orcid":"https://orcid.org/0000-0002-9120-6850","observed_orcids":["https://orcid.org/0000-0002-9120-6850"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C P O'Donnell","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602044","display_name":"Solbert Permutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Permutt","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110429494","display_name":"J. L. Robotham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Robotham","raw_affiliation_strings":["Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287-4965, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5856,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7302445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"152","issue":"2","first_page":"511","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venous-return","display_name":"venous return","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hepatic-blood-flow","display_name":"hepatic blood flow","score":0.6589999794960022},{"id":"https://openalex.org/keywords/portal-vein","display_name":"portal vein","score":0.6809999942779541},{"id":"https://openalex.org/keywords/hepatic-artery","display_name":"hepatic artery","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vascular-distensibility","display_name":"vascular distensibility","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pressure-flow-relationship","display_name":"pressure-flow relationship","score":0.8149999976158142},{"id":"https://openalex.org/keywords/zero-flow-pressure","display_name":"zero-flow pressure","score":0.8629999756813049},{"id":"https://openalex.org/keywords/central-venous-pressure","display_name":"central venous pressure","score":0.7630000114440918},{"id":"https://openalex.org/keywords/right-atrial-pressure","display_name":"right atrial pressure","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7187929749488831},{"id":"https://openalex.org/C56900294","wikidata":"https://www.wikidata.org/wiki/Q7231497","display_name":"Portal venous pressure","level":4,"score":0.6084241271018982},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5175713300704956},{"id":"https://openalex.org/C35207712","wikidata":"https://www.wikidata.org/wiki/Q190402","display_name":"Central venous pressure","level":4,"score":0.5033156275749207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44932985305786133},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44775575399398804},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.44312170147895813},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.31420034170150757},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.30575886368751526},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.11731305718421936},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.07025384902954102}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002496","descriptor_name":"Central Venous Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006499","descriptor_name":"Hepatic Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006503","descriptor_name":"Hepatic Veins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008102","descriptor_name":"Liver Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011169","descriptor_name":"Portal Vein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014690","descriptor_name":"Venous Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016280","descriptor_name":"Atrial Function, Right","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017082","descriptor_name":"Portal Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1164/ajrccm.152.2.7633700","doi":"https://doi.org/10.1164/ajrccm.152.2.7633700","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.152.2.7633700","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},{"id":"pmid:7633700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7633700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"},{"id":"pmh:oai:ricerca.uniba.it:11586/75684","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/75684","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G282342756","display_name":null,"funder_award_id":"R01-HL39138-04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6938721223","display_name":"TRANSIENT ANALYSIS OF CARDIORESPIRATORY INTERACTIONS","funder_award_id":"R01HL039138","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W195034981","https://openalex.org/W1880249534","https://openalex.org/W1927995007","https://openalex.org/W1954463628","https://openalex.org/W1964903138","https://openalex.org/W1968393536","https://openalex.org/W1970975423","https://openalex.org/W1972683398","https://openalex.org/W2006920342","https://openalex.org/W2039309934","https://openalex.org/W2100552924","https://openalex.org/W2131264636","https://openalex.org/W2256991736","https://openalex.org/W2273793512","https://openalex.org/W2305495481","https://openalex.org/W2347122814","https://openalex.org/W2400082435","https://openalex.org/W2400656214","https://openalex.org/W2401799840","https://openalex.org/W2412277753","https://openalex.org/W2417273825","https://openalex.org/W2417862931","https://openalex.org/W2418038315","https://openalex.org/W2427932062"],"related_works":["https://openalex.org/W2088955692","https://openalex.org/W2347122814","https://openalex.org/W2109667952","https://openalex.org/W2404818363","https://openalex.org/W7208121706","https://openalex.org/W2407151823","https://openalex.org/W2043065218","https://openalex.org/W2182120746","https://openalex.org/W2417499161","https://openalex.org/W2413050751"],"abstract_inverted_index":{"The":[0,28,97,187],"aim":[1],"of":[2,44,52,59,68,72,124,151,189],"the":[3,41,76,87,122,125,155,190,210,219,232,245],"study":[4,29],"was":[5,30,81,101,147],"to":[6,17,94,118,169,217],"determine":[7],"whether":[8],"closing":[9],"pressures":[10],"or":[11],"vascular":[12,204],"distensibility":[13],"can":[14],"be":[15],"used":[16],"describe":[18],"liver":[19,37,61,191],"venous":[20,222,228],"hemodynamics":[21],"when":[22],"right":[23],"atrial":[24],"pressure":[25,54,88,100,144,162,180,200],"is":[26,194,212,235],"raised.":[27],"performed":[31],"using":[32],"a":[33,84,135,159,177,197,202,251],"vascularly":[34],"isolated":[35],"pig":[36],"preparation":[38],"that":[39],"allowed":[40],"independent":[42],"control":[43],"portal":[45,77,126],"vein":[46,78,127,192],"and":[47,51,145,171,206],"hepatic":[48,156,233],"artery":[49,157,234],"inflows":[50],"outflow":[53],"(Pout).":[55],"Pressure-flow":[56],"(P-Q)":[57],"relationships":[58,129],"both":[60],"vessels":[62],"were":[63],"generated":[64],"at":[65,90],"multiple":[66],"levels":[67],"Pout.":[69,164],"At":[70,149],"Pout":[71,109,115,146,150,166,183],"0":[73,117,152,168],"mm":[74,105,120,153,173],"Hg,":[75,106,121,154],"P-Q":[79,128],"relationship":[80],"linear,":[82,133],"with":[83,134,224],"convexity":[85],"toward":[86],"axis":[89],"low":[91],"flows":[92],"(5":[93],"10":[95],"ml/min/kg).":[96],"zero":[98,142,160,178,198],"flow":[99,143,161,179,199],"1.5":[102],"+/-":[103],"0.2":[104],"greater":[107],"than":[108],"(p":[110,184],"<":[111,185],"0.05).":[112,186],"On":[113],"raising":[114],"from":[116,167,244],"15":[119,170],"shape":[123],"became":[130],"progressively":[131],"more":[132],"decrease":[136],"in":[137,176,221,240],"slope;":[138],"no":[139],"difference":[140],"between":[141],"observed.":[148],"presented":[158],">":[163,182],"Raising":[165],"30":[172],"Hg":[174],"resulted":[175],"always":[181],"behavior":[188],"system":[193],"characterized":[195],"by":[196,207,237],"mimicking":[201],"classic":[203],"waterfall":[205,211],"distensibility,":[208],"once":[209],"exceeded.":[213],"Both":[214],"factors":[215],"act":[216],"minimize":[218],"reduction":[220],"return":[223],"an":[225,238],"increased":[226],"central":[227],"pressure.":[229,254],"Flow":[230],"through":[231],"affected":[236],"increase":[239],"backpressure":[241],"occurring":[242],"upstream":[243],"sinusoids,":[246],"reducing":[247],"arterial":[248],"inflow":[249],"for":[250],"constant":[252],"perfusion":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
