{"id":"https://openalex.org/W2023837293","doi":"https://doi.org/10.1002/tox.2540020208","title":"Assessment for mutagenicity of 10 pharmaceutical products following ames, micronucleus, and sperm morphology testing","display_name":"Assessment for mutagenicity of 10 pharmaceutical products following ames, micronucleus, and sperm morphology testing","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W2023837293","doi":"https://doi.org/10.1002/tox.2540020208","mag":"2023837293"},"language":"en","primary_location":{"id":"doi:10.1002/tox.2540020208","doi":"https://doi.org/10.1002/tox.2540020208","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tox.2540020208","pdf_url":null,"source":{"id":"https://openalex.org/S4210189190","display_name":"Environmental Toxicology and Water Quality","issn_l":"0884-8181","issn":["0884-8181","1053-4725","1098-2256"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicity Assessment","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052867995","display_name":"I. S. Stoyanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114693","display_name":"Military Medical Academy","ror":"https://ror.org/032y5zj91","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210114693"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"I. S. Stoyanov","raw_affiliation_strings":["Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria","institution_ids":["https://openalex.org/I4210114693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051151239","display_name":"I. G. Nicolov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114693","display_name":"Military Medical Academy","ror":"https://ror.org/032y5zj91","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210114693"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"I. G. Nicolov","raw_affiliation_strings":["Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria","institution_ids":["https://openalex.org/I4210114693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052070227","display_name":"I. N. Chernozemsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114693","display_name":"Military Medical Academy","ror":"https://ror.org/032y5zj91","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210114693"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"I. N. Chernozemsky","raw_affiliation_strings":["Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria","institution_ids":["https://openalex.org/I4210114693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026333705","display_name":"I. Stoichev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114693","display_name":"Military Medical Academy","ror":"https://ror.org/032y5zj91","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210114693"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"I. Stoichev","raw_affiliation_strings":["Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oncology, Medical Academy, Sofia 1156, Bulgaria","institution_ids":["https://openalex.org/I4210114693"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114693"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.10208735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2","issue":"2","first_page":"207","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pharmaceuticals","display_name":"pharmaceuticals","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ames-test","display_name":"Ames test","score":0.8809999823570251},{"id":"https://openalex.org/keywords/micronucleus-test","display_name":"micronucleus test","score":0.890999972820282},{"id":"https://openalex.org/keywords/sperm-morphology","display_name":"sperm morphology","score":0.8059999942779541},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bdf1-mice","display_name":"BDF1 mice","score":0.8009999990463257},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.6069999933242798},{"id":"https://openalex.org/keywords/psychotropic-drugs","display_name":"psychotropic drugs","score":0.6800000071525574},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.9010000228881836},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.7039999961853027},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.8370000123977661},{"id":"https://openalex.org/keywords/isosorbide-dinitrate","display_name":"isosorbide dinitrate","score":0.8180000185966492},{"id":"https://openalex.org/keywords/trimethoprim","display_name":"trimethoprim","score":0.6380000114440918},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.7850000262260437},{"id":"https://openalex.org/keywords/false-negative-results","display_name":"false-negative results","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C117632636","wikidata":"https://www.wikidata.org/wiki/Q30912","display_name":"Ames test","level":4,"score":0.8594145774841309},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.7866085767745972},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.5316016674041748},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.49820566177368164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49168330430984497},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.4837627410888672},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4493086338043213},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.43779486417770386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31136736273765564},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.21373385190963745},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13792535662651062},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13157996535301208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09702029824256897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/tox.2540020208","doi":"https://doi.org/10.1002/tox.2540020208","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tox.2540020208","pdf_url":null,"source":{"id":"https://openalex.org/S4210189190","display_name":"Environmental Toxicology and Water Quality","issn_l":"0884-8181","issn":["0884-8181","1053-4725","1098-2256"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicity Assessment","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1601932516","https://openalex.org/W1925364214","https://openalex.org/W1971828811","https://openalex.org/W1973195696","https://openalex.org/W1997602782","https://openalex.org/W2005156172","https://openalex.org/W2018437991","https://openalex.org/W2042085026","https://openalex.org/W2047123751","https://openalex.org/W2056918710","https://openalex.org/W2110655913","https://openalex.org/W2162623233","https://openalex.org/W2167064556","https://openalex.org/W2400010363","https://openalex.org/W2411900205","https://openalex.org/W2508807672","https://openalex.org/W4231836309"],"related_works":["https://openalex.org/W2393621947","https://openalex.org/W2912903086","https://openalex.org/W1986255994","https://openalex.org/W4234392789","https://openalex.org/W2012555038","https://openalex.org/W1997602782","https://openalex.org/W2070313053","https://openalex.org/W2001039422","https://openalex.org/W2409451806","https://openalex.org/W2071187863"],"abstract_inverted_index":{"Abstract":[0],"Ten":[1],"widely":[2],"used":[3],"pharmaceutical":[4],"agents":[5],"for":[6],"which":[7],"mutagenicity":[8,24],"or":[9],"carcinogenicity":[10],"data":[11],"are":[12,97],"still":[13],"lacking":[14],"were":[15,56,88],"tested":[16,49],"in":[17],"parallel":[18],"with":[19],"three":[20],"methods:":[21],"Ames'":[22],"bacterial":[23],"test":[25],"(TA1535,":[26],"TA1537,":[27],"TA98,":[28],"and":[29,36,44,78],"TA100":[30],"Salmonella":[31],"strains),":[32],"micronucleus":[33],"(mice":[34],"BDF1),":[35],"sperm":[37],"morphology":[38],"abnormality":[39],"(mice)":[40],"tests.":[41],"The":[42],"groups":[43],"generic":[45],"names":[46],"of":[47],"the":[48,79],"products,":[50],"all":[51,84],"produced":[52],"by":[53],"Pharmachim":[54],"(Bulgaria),":[55],"as":[57],"follows:":[58],"Psychopharmaca":[59],"(Loxapinsuccinate,":[60],"Medazepam":[61],"hydrochloride,":[62],"Nomifensinmaleate,":[63],"Viloxazine":[64],"hydrochloride),":[65],"Vasodilatators":[66],"(Nitroprussid":[67],"Na,":[68],"Isosorbid":[69,71],"mononitrate,":[70],"dinitrate),":[72],"Spasmolytica":[73],"(Trimetoquinol),":[74],"Antirheumatica":[75],"(Diclofenac":[76],"Na),":[77],"antimycotic":[80],"agent":[81],"Lavendotricin.":[82],"In":[83],"tests,":[85],"negative":[86,93],"results":[87],"obtained.":[89],"To":[90],"avoid":[91],"false":[92],"results,":[94],"several":[95],"suggestions":[96],"made.":[98]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}