{"id":"https://openalex.org/W2023822010","doi":"https://doi.org/10.1210/jcem-70-5-1426","title":"Infusion of Low Dose Etomidate: Correction of Hypercortisolemia in Patients with Cushing's Syndrome and Dose-Response Relationship in Normal Subjects","display_name":"Infusion of Low Dose Etomidate: Correction of Hypercortisolemia in Patients with Cushing's Syndrome and Dose-Response Relationship in Normal Subjects","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W2023822010","doi":"https://doi.org/10.1210/jcem-70-5-1426","mag":"2023822010","pmid":"https://pubmed.ncbi.nlm.nih.gov/2159485"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-70-5-1426","doi":"https://doi.org/10.1210/jcem-70-5-1426","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-70-5-1426","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111728692","display_name":"Heinrich M. Schulte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"HEINRICH M. SCHULTE","raw_affiliation_strings":["I. Medizinische Klinik und Kinderklinik, Christian-Albrecht-Universit\u00e4t zu Kiel, West Germany","Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Medizinische Klinik und Kinderklinik, Christian-Albrecht-Universit\u00e4t zu Kiel, West Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017787563","display_name":"Georg Benker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"GEORG BENKER","raw_affiliation_strings":["Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073136435","display_name":"DANKWART REINWEIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"DANKWART REINWEIN","raw_affiliation_strings":["Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111694764","display_name":"Wolfgang G. Sippell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"WOLFGANG G. SIPPELL","raw_affiliation_strings":["Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090695853","display_name":"Bruno Allolio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"BRUNO ALLOLIO","raw_affiliation_strings":["Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel; Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen; und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik (H.M.S.) und Kinderklinik (W.G.S.) der Christian-Albrecht-Universit\u00e4t zu Kiel Kiel","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Medizinische Klinik und Poliklinik der Universitdt Essen (G.B., D.R.) Essen","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"und Medizinische Klinik II der Uniuersitat zu K\u00f6ln (BA) K\u00f6ln West Germany","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.5688,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.6566543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"70","issue":"5","first_page":"1426","last_page":"1430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etomidate","display_name":"etomidate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cortisol-suppression","display_name":"cortisol suppression","score":0.6240000128746033},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8579999804496765},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.7519999742507935},{"id":"https://openalex.org/keywords/11-deoxycortisol","display_name":"11-deoxycortisol","score":0.9390000104904175},{"id":"https://openalex.org/keywords/deoxycorticosterone","display_name":"deoxycorticosterone","score":0.890999972820282},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9440000057220459},{"id":"https://openalex.org/keywords/corticosterone","display_name":"corticosterone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/urinary-free-cortisol","display_name":"urinary free cortisol","score":0.6460000276565552},{"id":"https://openalex.org/keywords/adrenal-suppression","display_name":"adrenal suppression","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2779676917","wikidata":"https://www.wikidata.org/wiki/Q418445","display_name":"Etomidate","level":3,"score":0.9833387136459351},{"id":"https://openalex.org/C2910616045","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Hypercortisolemia","level":3,"score":0.7593368291854858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7029886245727539},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6782447099685669},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6314111948013306},{"id":"https://openalex.org/C2780352252","wikidata":"https://www.wikidata.org/wiki/Q422543","display_name":"Corticosterone","level":3,"score":0.6302527785301208},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6043104529380798},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5840552449226379},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.5249338746070862},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.49463674426078796},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.42307204008102417},{"id":"https://openalex.org/C3020190219","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous bolus","level":2,"score":0.4133342504501343},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2522653043270111},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19500267505645752},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005045","descriptor_name":"Etomidate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005045","descriptor_name":"Etomidate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-70-5-1426","doi":"https://doi.org/10.1210/jcem-70-5-1426","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-70-5-1426","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:2159485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2159485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1976463720","https://openalex.org/W1987857749","https://openalex.org/W1991729220","https://openalex.org/W1993116170","https://openalex.org/W1995094702","https://openalex.org/W1997406671","https://openalex.org/W2016508402","https://openalex.org/W2030473138","https://openalex.org/W2056649871","https://openalex.org/W2080720860","https://openalex.org/W2084727852","https://openalex.org/W2097430884","https://openalex.org/W2106187923","https://openalex.org/W2130159151","https://openalex.org/W2135414391","https://openalex.org/W2157313332","https://openalex.org/W4322703198"],"related_works":["https://openalex.org/W2094918838","https://openalex.org/W7100136347","https://openalex.org/W4405536924","https://openalex.org/W3021064512","https://openalex.org/W2905244054","https://openalex.org/W2066117697","https://openalex.org/W2981384003","https://openalex.org/W3094441435","https://openalex.org/W4252289853","https://openalex.org/W3026737635"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,84,96,127,130,157,200,215,249,302],"adrenostatic":[3],"potential":[4],"of":[5,25,50,55,70,120,129,142,161,239,242,291,304],"a":[6,18,165,234,265,274,289],"nonhypnotic":[7,267],"low":[8,125,181,266],"dose":[9,69,268,290],"etomidate":[10,16,61,85,121,162,201,251,263,287],"infusion,":[11,88],"we":[12],"administered":[13,77,262],"0.03":[14,71],"mg/kg":[15],"in":[17,44,91,168,196,219,228,233,264,273,277],"bolus":[19,68],"injection,":[20],"followed":[21],"by":[22,138],"constant":[23],"infusion":[24,122,212],"0.3":[26,59],"mg/kg.h":[27,60,293],"for":[28,62,301],"24":[29,139],"h":[30,64,119],"to":[31,75,112,135,151,164,174,186,191,199,209,226,237],"6":[32],"patients":[33],"with":[34],"severe":[35,305],"Cushing's":[36],"syndrome.":[37],"The":[38,73],"dose-response":[39],"relationship":[40],"also":[41],"was":[42,89],"determined":[43,90],"15":[45],"normal":[46,93,158,210,244],"subjects.":[47,94,282],"Three":[48],"groups":[49],"5":[51,63],"received,":[52],"respectively,":[53],"doses":[54],"0.03,":[56],"0.1,":[57],"and":[58,123,221,230,280],"after":[65,83,117,214],"an":[66,298],"initial":[67],"mg/kg.":[72],"response":[74,190],"exogenously":[76],"ACTH":[78],"[0.25":[79],"mg":[80],"ACTH-(1-24)],":[81],"injected":[82],"or":[86,182,294],"control":[87,303],"all":[92],"In":[95,156,189],"six":[97],"hypercortisolemic":[98],"patients,":[99],"serum":[100,169,270],"cortisol":[101,145,170,193,271],"concentrations":[102,137,223,272],"decreased":[103,146],"from":[104,147,171,180],"1374":[105],"+/-":[106,110,114,149,153],"436":[107],"nmol/L":[108,116],"(mean":[109],"SEM)":[111],"188":[113],"91":[115],"11":[118],"remained":[124],"until":[126],"end":[128],"infusion.":[131,252],"Cortisol":[132],"levels":[133,184,194],"returned":[134],"pretreatment":[136],"h.":[140],"Excretion":[141],"urinary":[143],"free":[144],"1180":[148],"196":[150],"185":[152],"66":[154],"nmol/day.":[155],"subjects,":[159],"administration":[160],"led":[163],"dose-dependent":[166,275],"decrease":[167],"about":[172],"550":[173],"83":[175],"nmol/L,":[176],"while":[177],"11-deoxycortisol":[178],"rose":[179,195],"undetectable":[183],"up":[185],"346":[187],"nmol/L.":[188],"ACTH,":[192],"inverse":[197],"proportion":[198],"dose.":[202,217],"It":[203],"was,":[204],"however,":[205],"significantly":[206],"reduced":[207],"compared":[208],"saline":[211],"even":[213],"lowest":[216],"Changes":[218],"aldosterone":[220],"corticosterone":[222],"were":[224,256],"similar":[225,236],"those":[227],"cortisol,":[229],"11-deoxycorticosterone":[231],"changed":[232],"pattern":[235],"that":[238,260,286],"11-deoxycortisol.":[240],"Two":[241],"five":[243],"subjects":[245],"reported":[246],"tiredness":[247],"during":[248],"highest":[250],"No":[253],"other":[254],"side-effects":[255],"noted.":[257],"We":[258],"conclude":[259],"iv":[261],"reduces":[269],"manner":[276],"both":[278],"hyper-":[279],"eucortisolemic":[281],"This":[283],"study":[284],"suggests":[285],"at":[288],"0.1":[292],"lower":[295],"may":[296],"be":[297],"effective":[299],"strategy":[300],"hypercortisolemia.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
