{"id":"https://openalex.org/W202376510","doi":null,"title":"Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment.","display_name":"Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment.","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W202376510","mag":"202376510","pmid":"https://pubmed.ncbi.nlm.nih.gov/18065337"},"language":"en","primary_location":{"id":"pmid:18065337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18065337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091741479","display_name":"Murat \u0130kizler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Murat Ikizler","raw_affiliation_strings":["Department of Cardiovascular Surgery, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey. mikizler@ogu.edu.tr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Eski\u015fehir Osmangazi University, Eski\u015fehir, Turkey. mikizler@ogu.edu.tr","institution_ids":["https://openalex.org/I51209816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061151008","display_name":"Nil\u00fcfer Erkasap","orcid":"https://orcid.org/0000-0002-2742-3519","observed_orcids":["https://orcid.org/0000-0002-2742-3519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nil\u00fcfer Erkasap","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075748373","display_name":"Sadettin Dernek","orcid":"https://orcid.org/0000-0002-0865-7694","observed_orcids":["https://orcid.org/0000-0002-0865-7694","https://orcid.org/0000-0001-6997-6421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadettin Dernek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023706067","display_name":"Tu\u011frul Kural","orcid":"https://orcid.org/0000-0003-3499-4915","observed_orcids":["https://orcid.org/0000-0003-3499-4915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tu\u011frul Kural","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047165973","display_name":"Ziya Kayg\u0131s\u0131z","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ziya Kaygisiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6781,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.90242001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"7","issue":"4","first_page":"404","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.949999988079071},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chronic-dietary-supplementation","display_name":"chronic dietary supplementation","score":0.609000027179718},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.8379999995231628},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cardiac-troponin-i","display_name":"cardiac troponin I","score":0.7710000276565552},{"id":"https://openalex.org/keywords/myocardial-hemodynamics","display_name":"myocardial hemodynamics","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cardiac-recovery","display_name":"cardiac function recovery","score":0.45100000500679016},{"id":"https://openalex.org/keywords/red-wine-polyphenols","display_name":"red wine polyphenols","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8215218782424927},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.7403692603111267},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5320188999176025},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5256475210189819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.513480007648468},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5003063678741455},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.47832512855529785},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4704890251159668},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4485015273094177},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4231044054031372},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34880131483078003},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3421393036842346},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10802099108695984},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07879209518432617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07723882794380188}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005980","descriptor_name":"Glutathione Reductase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038441","descriptor_name":"Diet, Mediterranean","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18065337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18065337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology","raw_type":"Journal Article"},{"id":"mag:202376510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18065337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W132595253","https://openalex.org/W1569975913","https://openalex.org/W1590563400","https://openalex.org/W1630602822","https://openalex.org/W1900499697","https://openalex.org/W1968984653","https://openalex.org/W1969555927","https://openalex.org/W1983310681","https://openalex.org/W2006424114","https://openalex.org/W2010099805","https://openalex.org/W2010807769","https://openalex.org/W2022386305","https://openalex.org/W2027605059","https://openalex.org/W2040692157","https://openalex.org/W2046446382","https://openalex.org/W2060067383","https://openalex.org/W2083310921","https://openalex.org/W2145047941","https://openalex.org/W2146346788","https://openalex.org/W2165471414","https://openalex.org/W2169386176","https://openalex.org/W2210726304","https://openalex.org/W2399326962","https://openalex.org/W2409977159","https://openalex.org/W2415947839"],"related_works":["https://openalex.org/W2030341689","https://openalex.org/W2887796368","https://openalex.org/W2349303141","https://openalex.org/W4408021674","https://openalex.org/W7220702001","https://openalex.org/W1965994212","https://openalex.org/W7170039065","https://openalex.org/W1965574611","https://openalex.org/W2083310921","https://openalex.org/W2522066867"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Quercetin":[1,190],"is":[2,26,304,326],"an":[3,54,113,128],"important":[4],"member":[5],"of":[6,22,32,42,80,86,139,309,315],"dietary":[7,275],"flavonoid":[8],"family":[9],"and":[10,16,105,124,155,172,180,201,223,240,249,259,268,281,296],"widely":[11],"present":[12],"in":[13,34,47,66,186,195,198,234,256],"red":[14],"wine":[15],"Mediterranean":[17],"diet.":[18],"The":[19,141],"major":[20,274],"objective":[21],"the":[23,29,36,39,137,216,286,290,302,307],"this":[24,67,229,312,324],"study":[25],"to":[27,78,206,210,244,265,278,288],"evaluate":[28],"beneficial":[30],"effects":[31,41],"quercetin":[33,49,56,111,284],"protecting":[35],"myocardium":[37],"from":[38,169,182],"deleterious":[40],"ischemia":[43,82,295],"reperfusion":[44,297],"(I/R)":[45],"injury":[46],"chronic":[48,120,200,235,260,333],"treatment":[50,203,334],"with":[51],"or":[52],"without":[53],"acute":[55,129,202,220,257,310],"infusion":[57,132],"protocols.":[58],"METHODS:":[59],"Forty":[60],"male":[61],"Sprague-Dawley":[62],"rats":[63],"were":[64,76,90,99],"included":[65],"experimental":[68],"randomized":[69],"study/":[70],"Langendorff":[71],"perfused":[72],"isolated":[73],"rat":[74],"hearts":[75,222,225,262],"subjected":[77],"60-min":[79,85],"global":[81,294],"period":[83],"following":[84],"reperfusion.":[87],"All":[88],"animals":[89,98,107,126],"randomly":[91],"divided":[92],"into":[93],"4":[94,106,125],"groups.":[95],"Group":[96,103,122],"1":[97],"kept":[100],"as":[101,331],"controls.":[102],"3":[104,239],"received":[108,127],"50":[109],"mg/kg":[110],"via":[112],"intragastric":[114],"tube":[115],"for":[116,119,133,306,336],"7":[117],"days":[118],"treatment.":[121],"2":[123],"15":[130],"mmol/L":[131],"30":[134],"minutes":[135],"before":[136],"onset":[138],"ischemia.":[140],"myocardial":[142,196,291],"postischemic":[143],"recovery":[144,197],"was":[145,226,231],"compared":[146,205,243,264],"using":[147],"hemodynamic":[148,213],"data":[149],"(peak":[150],"systolic":[151],"pressure,":[152],"end-diastolic":[153],"pressure":[154],"+dP/dtmax),":[156],"coronary":[157,170],"flow,":[158],"biochemical":[159,248],"parameters":[160],"(lactate":[161],"dehydrogenase,":[162],"creatine":[163],"kinase-MB":[164],"fraction,":[165],"cardiac":[166],"troponin":[167],"I)":[168],"effluent,":[171],"oxidative":[173,250],"stress":[174,251],"markers":[175,252],"(malondialdehyde,":[176],"glutathione,":[177],"glutathione":[178],"reductase":[179],"nitrite)":[181],"heart":[183],"tissue":[184,292],"homogenates":[185],"each":[187],"group.":[188,208],"RESULTS:":[189],"has":[191,285],"provided":[192],"increased":[193],"preservation":[194],"both":[199],"protocols":[204],"non-treated":[207],"According":[209],"all":[211],"estimated":[212],"parameters,":[214],"while":[215],"statistical":[217],"difference":[218],"between":[219],"treated":[221,236,258,261],"control":[224,245,266],"significant":[227,254,317],"(p<0.05);":[228],"significance":[230],"more":[232],"clear":[233],"groups":[237],"(group":[238],"4)":[241],"when":[242,263],"(p<0.01).":[246],"Likewise,":[247],"displayed":[253],"differences":[255],"(p<0.05":[267],"p<0.01,":[269],"respectively).":[270],"CONCLUSION:":[271],"As":[272],"a":[273,316,332],"flavonoid,":[276],"due":[277],"its":[279],"antioxidant":[280],"cytoprotective":[282],"actions,":[283],"capacity":[287],"protect":[289],"against":[293],"injury.":[298],"In":[299],"instances":[300],"where":[301],"molecule":[303],"administered":[305],"purpose":[308],"therapy,":[311],"cardioprotective":[313],"effect":[314],"degree":[318],"can":[319],"be":[320],"observed":[321],"to;":[322],"however,":[323],"potency":[325],"further":[327],"accentuated":[328],"upon":[329],"administration":[330],"protocol":[335],"seven":[337],"days.":[338]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}