{"id":"https://openalex.org/W2023738576","doi":"https://doi.org/10.1242/jcs.02316","title":"Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment","display_name":"Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment","publication_year":2005,"publication_date":"2005-04-19","ids":{"openalex":"https://openalex.org/W2023738576","doi":"https://doi.org/10.1242/jcs.02316","mag":"2023738576","pmid":"https://pubmed.ncbi.nlm.nih.gov/15840656"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.02316","doi":"https://doi.org/10.1242/jcs.02316","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.02316","pdf_url":"https://journals.biologists.com/jcs/article-pdf/118/9/1971/1520461/1971.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.biologists.com/jcs/article-pdf/118/9/1971/1520461/1971.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019899805","display_name":"Aida Habtezion","orcid":"https://orcid.org/0000-0002-4473-006X","observed_orcids":["https://orcid.org/0000-0002-4473-006X"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aida Habtezion","raw_affiliation_strings":["Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066897632","display_name":"Diana M. Toivola","orcid":"https://orcid.org/0000-0001-7165-9839","observed_orcids":["https://orcid.org/0000-0001-7165-9839"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana M. Toivola","raw_affiliation_strings":["Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035047473","display_name":"Eugene C. Butcher","orcid":"https://orcid.org/0000-0001-8786-7907","observed_orcids":["https://orcid.org/0000-0001-8786-7907","https://orcid.org/0000-0001-7422-1453"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene C. Butcher","raw_affiliation_strings":["Department of Pathology, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007337339","display_name":"M. Bishr Omary","orcid":"https://orcid.org/0000-0002-8624-2347","observed_orcids":["https://orcid.org/0000-0002-8624-2347"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Bishr Omary","raw_affiliation_strings":["Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Palo Alto VA Medical Center, 3801 Miranda Avenue, 154J, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Stanford University School of Medicine Digestive Disease Center, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007337339","https://openalex.org/A5019899805"],"corresponding_institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":2.7239,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.8910853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"118","issue":"9","first_page":"1971","last_page":"1980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratin-8","display_name":"keratin 8","score":0.902999997138977},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6800000071525574},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mhc-class-ii-expression","display_name":"MHC class II expression","score":0.6800000071525574},{"id":"https://openalex.org/keywords/integrin-alpha4beta7","display_name":"alpha4beta7 integrin","score":0.765999972820282},{"id":"https://openalex.org/keywords/madcam-1","display_name":"MAdCAM-1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lymphocyte-homing","display_name":"lymphocyte homing","score":0.6309999823570251},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C4175445","wikidata":"https://www.wikidata.org/wiki/Q14907568","display_name":"Addressin","level":4,"score":0.8854212760925293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7890539169311523},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.635679304599762},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6072379350662231},{"id":"https://openalex.org/C50548948","wikidata":"https://www.wikidata.org/wiki/Q14907896","display_name":"Keratin 8","level":3,"score":0.5187473297119141},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47582510113716125},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4667183756828308},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2035955786705017},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.19503098726272583},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12530776858329773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009088","descriptor_name":"Mucoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016827","descriptor_name":"CD8 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1242/jcs.02316","doi":"https://doi.org/10.1242/jcs.02316","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.02316","pdf_url":"https://journals.biologists.com/jcs/article-pdf/118/9/1971/1520461/1971.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:15840656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15840656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:118/9/1971","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/118/9/1971","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pure.atira.dk:publications/24de69b6-4eea-4141-ae62-8654851fd060","doi":null,"is_oa":false,"landing_page_url":"https://research.abo.fi/en/publications/24de69b6-4eea-4141-ae62-8654851fd060","pdf_url":null,"source":{"id":"https://openalex.org/S4406923060","display_name":"\u00c5bo Akademi University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Habtezion, A, Toivola, D, Butcher, EC & Omary, MB 2005, 'Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment', Journal of Cell Science, vol. 118, pp. 1971\u20131980. https://doi.org/10.1242/jcs.02316","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1242/jcs.02316","doi":"https://doi.org/10.1242/jcs.02316","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.02316","pdf_url":"https://journals.biologists.com/jcs/article-pdf/118/9/1971/1520461/1971.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3297101552","display_name":null,"funder_award_id":"AI-47822","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4440821290","display_name":"Keratin Biology and Disease Aspects in Simple Epithelia","funder_award_id":"R01DK047918","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5610264361","display_name":"Molecular Pathogenesis of Digestive Diseases","funder_award_id":"P30DK056339","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000121938","display_name":null,"funder_award_id":"AI47822","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000915805","display_name":"Training Grant in Academic Gastroenterology","funder_award_id":"T32DK007056","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2023738576.pdf","grobid_xml":"https://content.openalex.org/works/W2023738576.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W168699217","https://openalex.org/W1531265936","https://openalex.org/W1536547862","https://openalex.org/W1583750739","https://openalex.org/W1602460865","https://openalex.org/W1619160309","https://openalex.org/W1764985617","https://openalex.org/W1773874353","https://openalex.org/W1981327571","https://openalex.org/W1984610550","https://openalex.org/W1988379927","https://openalex.org/W2000208875","https://openalex.org/W2001835390","https://openalex.org/W2010256250","https://openalex.org/W2016253390","https://openalex.org/W2016693266","https://openalex.org/W2017443683","https://openalex.org/W2024164044","https://openalex.org/W2027586189","https://openalex.org/W2034285135","https://openalex.org/W2042626190","https://openalex.org/W2049672237","https://openalex.org/W2052386537","https://openalex.org/W2052532122","https://openalex.org/W2073542790","https://openalex.org/W2075658584","https://openalex.org/W2094273511","https://openalex.org/W2096539266","https://openalex.org/W2099376515","https://openalex.org/W2100589138","https://openalex.org/W2126742810","https://openalex.org/W2128443448","https://openalex.org/W2138223843","https://openalex.org/W2141597037","https://openalex.org/W2141679700","https://openalex.org/W2145164692","https://openalex.org/W2146605967","https://openalex.org/W2148455779","https://openalex.org/W2150605496","https://openalex.org/W2152910353","https://openalex.org/W2153261285","https://openalex.org/W2165528446","https://openalex.org/W2342314812","https://openalex.org/W4245481577","https://openalex.org/W4292198229"],"related_works":["https://openalex.org/W2619136378","https://openalex.org/W1529471039","https://openalex.org/W148314865","https://openalex.org/W2397227857","https://openalex.org/W2075994961","https://openalex.org/W1536547862","https://openalex.org/W4200089177","https://openalex.org/W4372284339","https://openalex.org/W7098336152","https://openalex.org/W2012066742"],"abstract_inverted_index":{"Keratin":[0],"8":[1],"(K8)":[2],"is":[3,133,223],"the":[4,15,34,49,91,201],"major":[5],"intermediate":[6],"filament":[7],"protein":[8],"present":[9],"in":[10,42,45,74,86,95,178,200],"intestinal":[11,50],"epithelia.":[12],"Depending":[13],"on":[14],"mouse":[16],"genetic":[17],"background,":[18],"absence":[19],"of":[20,39,52,61,77,111,154,159,168],"K8":[21],"causes":[22],"embryonic":[23],"lethality":[24],"or":[25],"colonic":[26],"hyperplasia":[27],"and":[28,37,64,67,69,103,121,143,146,171,187,236],"colitis.":[29,54],"We":[30],"studied":[31],"disease":[32],"progression,":[33],"inflammatory":[35],"responses,":[36],"role":[38,199],"luminal":[40,194],"bacteria":[41,195],"K8-null":[43,179,205],"mice":[44,76,81,107,206,229],"order":[46],"to":[47,115,135,213,225,233],"characterize":[48],"pathology":[51],"K8-associated":[53],"Colon":[55],"lymphocytes":[56],"were":[57],"isolated":[58],"for":[59],"analysis":[60],"their":[62,122],"phenotype":[63],"cytokine":[65,100],"production,":[66],"vascular":[68,149,172],"lymphocyte":[70],"adhesion":[71,176],"molecule":[72],"expression":[73,153],"K8-/-":[75,80,106],"varying":[78],"ages.":[79],"had":[82],"a":[83,214,231],"marked":[84],"increase":[85],"TCR(beta)-positive/CD4-positive":[87],"T":[88,139],"cells":[89,124,140,170],"infiltrating":[90,138],"colon":[92,185],"lamina":[93],"propria,":[94],"association":[96],"with":[97,119,151],"enhanced":[98],"Th2":[99],"(IL-4,":[101],"IL-5":[102],"IL-13)":[104],"production.":[105],"show":[108],"early":[109],"signs":[110],"inflammation":[112,186],"even":[113],"prior":[114],"weaning,":[116],"that":[117,193],"increases":[118],"age,":[120],"epithelial":[123,216],"overexpress":[125],"MHC":[126],"class":[127],"II":[128],"antigens.":[129],"The":[130],"chronic":[131,208],"colitis":[132,211],"related":[134],"increased":[136,166],"CD4-positive":[137],"displaying":[141],"memory":[142],"naive":[144],"phenotypes,":[145],"an":[147,165,197],"altered":[148],"endothelium":[150],"aberrant":[152],"peripheral":[155],"node":[156],"addressin.":[157],"Analysis":[158],"normal":[160],"gut-specific":[161],"homing":[162],"molecules,":[163],"reveals":[164],"number":[167],"alpha(4)beta(7)-positive":[169],"mucosal":[173],"addressin":[174],"cell":[175,220],"molecule-1":[177],"colons.":[180],"Antibiotic":[181],"treatment":[182],"markedly":[183],"decreased":[184],"ion":[188],"transporter":[189],"AE1/2":[190],"mistargeting,":[191],"indicating":[192],"play":[196],"important":[198],"observed":[202],"phenotype.":[203],"Therefore,":[204],"develop":[207],"spontaneous":[209],"Th2-type":[210],"due":[212],"primary":[215],"rather":[217],"than":[218],"immune":[219],"defect,":[221],"which":[222],"amenable":[224],"antibiotic":[226],"therapy.":[227],"These":[228],"provide":[230],"model":[232],"investigate":[234],"epithelial-leukocyte":[235],"epithelial-microbial":[237],"cross-talk.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
