{"id":"https://openalex.org/W2023364466","doi":"https://doi.org/10.1016/0092-8674(88)90470-9","title":"A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli","display_name":"A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W2023364466","doi":"https://doi.org/10.1016/0092-8674(88)90470-9","mag":"2023364466","pmid":"https://pubmed.ncbi.nlm.nih.gov/2830029"},"language":"en","primary_location":{"id":"doi:10.1016/0092-8674(88)90470-9","doi":"https://doi.org/10.1016/0092-8674(88)90470-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(88)90470-9","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055443428","display_name":"Christopher F. Higgins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher F. Higgins","raw_affiliation_strings":["Department of Biochemistry, University of Dundee, Scotland","Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Dundee, Scotland","institution_ids":["https://openalex.org/I177639307"]},{"raw_affiliation_string":"Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN Scotland","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009549280","display_name":"Charles J. Dorman","orcid":"https://orcid.org/0000-0002-6018-9170","observed_orcids":["https://orcid.org/0000-0002-6018-9170"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charles J. Dorman","raw_affiliation_strings":["Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN, Scotland","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089883334","display_name":"Douglas A. Stirling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Douglas A. Stirling","raw_affiliation_strings":["Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN, Scotland","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007613246","display_name":"Lesley Waddell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lesley Waddell","raw_affiliation_strings":["Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory Department of Biochemistry University of Dundee Dundee DD1 4HN, Scotland","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111427008","display_name":"Ian R. Booth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian R. Booth","raw_affiliation_strings":["Department of Microbiology and Genetics University of Aberdeen Aberdeen AB9 1AS, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Genetics University of Aberdeen Aberdeen AB9 1AS, Scotland","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043759747","display_name":"Gerhard May","orcid":"https://orcid.org/0000-0002-2532-6758","observed_orcids":["https://orcid.org/0000-0002-2532-6758"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard May","raw_affiliation_strings":["Department of Biology, University of Konstanz, PO Box 5560, D-7750 Konstanz, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Konstanz, PO Box 5560, D-7750 Konstanz, Federal Republic of Germany","institution_ids":["https://openalex.org/I189712700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046618148","display_name":"Erhard Bremer","orcid":"https://orcid.org/0000-0002-2225-7005","observed_orcids":["https://orcid.org/0000-0002-2225-7005"]},"institutions":[{"id":"https://openalex.org/I189712700","display_name":"University of Konstanz","ror":"https://ror.org/0546hnb39","country_code":"DE","type":"education","lineage":["https://openalex.org/I189712700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erhard Bremer","raw_affiliation_strings":["Department of Biology, University of Konstanz, PO Box 5560, D-7750 Konstanz, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Konstanz, PO Box 5560, D-7750 Konstanz, Federal Republic of Germany","institution_ids":["https://openalex.org/I189712700"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":23.9402,"has_fulltext":false,"cited_by_count":715,"citation_normalized_percentile":{"value":0.99873257,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"52","issue":"4","first_page":"569","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-supercoiling","display_name":"DNA supercoiling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.8500000238418579},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/topa","display_name":"topA","score":0.6290000081062317},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8930000066757202},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9929999709129333},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/osmotic-adaptation","display_name":"osmoadaptation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/ompf","display_name":"OmpF","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ompc","display_name":"OmpC","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fima","display_name":"fimA","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bgl-operon","display_name":"bgl operon","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C158456008","wikidata":"https://www.wikidata.org/wiki/Q412639","display_name":"DNA supercoil","level":4,"score":0.949687123298645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8643190860748291},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.7513806819915771},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.6208216547966003},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5857341885566711},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5136918425559998},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48686283826828003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.465488076210022},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46294084191322327},{"id":"https://openalex.org/C179069550","wikidata":"https://www.wikidata.org/wiki/Q7180971","display_name":"Phase variation","level":4,"score":0.4430847764015198},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4200442433357239},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.41536635160446167},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.19885119795799255},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.14875492453575134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14678719639778137},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.14462387561798096}],"mesh":[{"descriptor_ui":"D001622","descriptor_name":"Betaine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004278","descriptor_name":"DNA, Superhelical","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/0092-8674(88)90470-9","doi":"https://doi.org/10.1016/0092-8674(88)90470-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0092-8674(88)90470-9","pdf_url":null,"source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:2830029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2830029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:205260","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/205260/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W87019046","https://openalex.org/W143022191","https://openalex.org/W1022642962","https://openalex.org/W1458283204","https://openalex.org/W1483230445","https://openalex.org/W1483396522","https://openalex.org/W1485095106","https://openalex.org/W1486955858","https://openalex.org/W1500494043","https://openalex.org/W1501308253","https://openalex.org/W1512374553","https://openalex.org/W1531812761","https://openalex.org/W1537831154","https://openalex.org/W1539488471","https://openalex.org/W1546783991","https://openalex.org/W1552284012","https://openalex.org/W1555593260","https://openalex.org/W1556903685","https://openalex.org/W1564031035","https://openalex.org/W1584931839","https://openalex.org/W1586559853","https://openalex.org/W1588664883","https://openalex.org/W1596478298","https://openalex.org/W1598546208","https://openalex.org/W1599116685","https://openalex.org/W1620357615","https://openalex.org/W1696841837","https://openalex.org/W1698614185","https://openalex.org/W1708604775","https://openalex.org/W1711115402","https://openalex.org/W1720245305","https://openalex.org/W1782700290","https://openalex.org/W1799406891","https://openalex.org/W1823805550","https://openalex.org/W1912830421","https://openalex.org/W1940781171","https://openalex.org/W1959857562","https://openalex.org/W1964108835","https://openalex.org/W1965532529","https://openalex.org/W1968650967","https://openalex.org/W1968996043","https://openalex.org/W1969049566","https://openalex.org/W1970430624","https://openalex.org/W1971425374","https://openalex.org/W1972424827","https://openalex.org/W1978235532","https://openalex.org/W1981897803","https://openalex.org/W1984360565","https://openalex.org/W1984626765","https://openalex.org/W1985345774","https://openalex.org/W1986115510","https://openalex.org/W1990963283","https://openalex.org/W1992238200","https://openalex.org/W1993165949","https://openalex.org/W1993971869","https://openalex.org/W1997131813","https://openalex.org/W2011686415","https://openalex.org/W2017036937","https://openalex.org/W2019410656","https://openalex.org/W2031053922","https://openalex.org/W2031717136","https://openalex.org/W2032359606","https://openalex.org/W2033313498","https://openalex.org/W2042814467","https://openalex.org/W2045710759","https://openalex.org/W2047606118","https://openalex.org/W2049639006","https://openalex.org/W2057203470","https://openalex.org/W2057481976","https://openalex.org/W2057854477","https://openalex.org/W2060417297","https://openalex.org/W2063227644","https://openalex.org/W2071829103","https://openalex.org/W2072406605","https://openalex.org/W2072859411","https://openalex.org/W2075786946","https://openalex.org/W2078089931","https://openalex.org/W2078864852","https://openalex.org/W2079053054","https://openalex.org/W2084550319","https://openalex.org/W2084586272","https://openalex.org/W2084971218","https://openalex.org/W2085094910","https://openalex.org/W2122257837","https://openalex.org/W2132911413","https://openalex.org/W2136771065","https://openalex.org/W2139675851","https://openalex.org/W2141653906","https://openalex.org/W2146827949","https://openalex.org/W2147746526","https://openalex.org/W2151938785","https://openalex.org/W2164849104","https://openalex.org/W2169763389","https://openalex.org/W2317250816","https://openalex.org/W2405461894","https://openalex.org/W2416497829","https://openalex.org/W4233567369"],"related_works":["https://openalex.org/W1545159404","https://openalex.org/W2403126506","https://openalex.org/W2884130748","https://openalex.org/W2027425484","https://openalex.org/W2035721356","https://openalex.org/W2010321216","https://openalex.org/W2012374243","https://openalex.org/W2117249826","https://openalex.org/W1981369765","https://openalex.org/W2056714168"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
