{"id":"https://openalex.org/W2023354564","doi":"https://doi.org/10.1007/bf02628664","title":"The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections","display_name":"The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W2023354564","doi":"https://doi.org/10.1007/bf02628664","mag":"2023354564","pmid":"https://pubmed.ncbi.nlm.nih.gov/8993765"},"language":"en","primary_location":{"id":"doi:10.1007/bf02628664","doi":"https://doi.org/10.1007/bf02628664","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02628664","pdf_url":null,"source":{"id":"https://openalex.org/S4210185807","display_name":"Biotherapy","issn_l":"0921-299X","issn":["0921-299X","1573-8280"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056840163","display_name":"I H\u00e1na","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ivo Hana","raw_affiliation_strings":["Dept. of Immunology, Institute for Clinical and Experimental Medicine, Prague, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Immunology, Institute for Clinical and Experimental Medicine, Prague, Czechia","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058567428","display_name":"J Vrubel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127955","display_name":"Institute of Clinical and Experimental Medicine","ror":"https://ror.org/036zr1b90","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210127955"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jiri Vrubel","raw_affiliation_strings":["Department of Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210127955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079563481","display_name":"J Pek\u00e1rek","orcid":"https://orcid.org/0000-0002-9857-1981","observed_orcids":["https://orcid.org/0000-0002-9857-1981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Pekarek","raw_affiliation_strings":["Institute of Sera and Vaccines, Prague, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sera and Vaccines, Prague, Czechia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003786016","display_name":"K Cech","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karel Cech","raw_affiliation_strings":["Institute of Sera and Vaccines, Prague, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sera and Vaccines, Prague, Czechia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2544,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.51548629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"1-3","first_page":"91","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transfer-factor","display_name":"transfer factor","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cellular-immunodeficiency","display_name":"cellular immunodeficiency","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chronic-viral-infection","display_name":"chronic viral infection","score":0.9359999895095825},{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7300000190734863},{"id":"https://openalex.org/keywords/t-cell-count","display_name":"T-cell count","score":0.75},{"id":"https://openalex.org/keywords/absolute-lymphocyte-count","display_name":"absolute lymphocyte count","score":0.7480000257492065},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2779566273","wikidata":"https://www.wikidata.org/wiki/Q209733","display_name":"Chronic fatigue syndrome","level":2,"score":0.6769822239875793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5901833176612854},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4984002113342285},{"id":"https://openalex.org/C2781128717","wikidata":"https://www.wikidata.org/wiki/Q1133884","display_name":"Transfer factor","level":2,"score":0.48683470487594604},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4657870829105377},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4522746205329895},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4498799741268158},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30882561206817627},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.05400705337524414}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014165","descriptor_name":"Transfer Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02628664","doi":"https://doi.org/10.1007/bf02628664","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02628664","pdf_url":null,"source":{"id":"https://openalex.org/S4210185807","display_name":"Biotherapy","issn_l":"0921-299X","issn":["0921-299X","1573-8280"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotherapy","raw_type":"journal-article"},{"id":"pmid:8993765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8993765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotherapy (Dordrecht, Netherlands)","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1976653613","https://openalex.org/W1993257712","https://openalex.org/W1995309025","https://openalex.org/W2002373619","https://openalex.org/W2030183133","https://openalex.org/W2039791749","https://openalex.org/W2040900427","https://openalex.org/W2052747235","https://openalex.org/W2084330444","https://openalex.org/W2098287790","https://openalex.org/W2312328448","https://openalex.org/W2342123488","https://openalex.org/W2397464867","https://openalex.org/W2779663048"],"related_works":["https://openalex.org/W2431153942","https://openalex.org/W2179473069","https://openalex.org/W2057148624","https://openalex.org/W165431482","https://openalex.org/W2507341097","https://openalex.org/W2372154159","https://openalex.org/W7024211285","https://openalex.org/W2032479717","https://openalex.org/W4220839646","https://openalex.org/W4200298634"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
