{"id":"https://openalex.org/W2023314902","doi":"https://doi.org/10.1002/bip.360310105","title":"Heteronuclear two\u2010dimensional 15N\u2010 and 13C\u2010nmr studies of DNA oligomers and their netropsin complexes using indirect proton detection","display_name":"Heteronuclear two\u2010dimensional 15N\u2010 and 13C\u2010nmr studies of DNA oligomers and their netropsin complexes using indirect proton detection","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2023314902","doi":"https://doi.org/10.1002/bip.360310105","mag":"2023314902","pmid":"https://pubmed.ncbi.nlm.nih.gov/1851045"},"language":"en","primary_location":{"id":"doi:10.1002/bip.360310105","doi":"https://doi.org/10.1002/bip.360310105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bip.360310105","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048813235","display_name":"Joseph S. Ashcroft","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Ashcroft","raw_affiliation_strings":["Rockefeller University, New York, New York 10021","The Rockefeller University, 1230 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073108061","display_name":"David H. Live","orcid":"https://orcid.org/0000-0003-2187-6872","observed_orcids":["https://orcid.org/0000-0003-2187-6872"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Live","raw_affiliation_strings":["Department of Chemistry, Emory University, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077706769","display_name":"Dinshaw J. Patel","orcid":"https://orcid.org/0000-0002-9779-7778","observed_orcids":["https://orcid.org/0000-0002-9779-7778"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dinshaw J. Patel","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018456881","display_name":"David Cowburn","orcid":"https://orcid.org/0000-0001-6770-7172","observed_orcids":["https://orcid.org/0000-0001-6770-7172"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Cowburn","raw_affiliation_strings":["The Rockefeller University, 1230 York Avenue, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, 1230 York Avenue, New York, New York 10021","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.1125,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75643371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"1","first_page":"45","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/netropsin","display_name":"netropsin","score":0.859000027179718},{"id":"https://openalex.org/keywords/dna-oligomers","display_name":"DNA oligomers","score":0.7269999980926514},{"id":"https://openalex.org/keywords/double-stranded-dna","display_name":"double-stranded DNA","score":0.800000011920929},{"id":"https://openalex.org/keywords/proton-detected-nmr","display_name":"proton-detected NMR","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dna-drug-complexes","display_name":"DNA-drug complexes","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C92381491","wikidata":"https://www.wikidata.org/wiki/Q5747409","display_name":"Heteronuclear molecule","level":3,"score":0.953499436378479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9115006923675537},{"id":"https://openalex.org/C2781063032","wikidata":"https://www.wikidata.org/wiki/Q3874969","display_name":"Netropsin","level":4,"score":0.681466817855835},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.5784732699394226},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4558890461921692},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.34974658489227295},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.338030606508255},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3228922188282013},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.13312998414039612},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08652341365814209},{"id":"https://openalex.org/C3019303373","wikidata":"https://www.wikidata.org/wiki/Q60535862","display_name":"Minor groove","level":3,"score":0.08436191082000732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07192739844322205}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009429","descriptor_name":"Netropsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bip.360310105","doi":"https://doi.org/10.1002/bip.360310105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bip.360310105","pdf_url":null,"source":{"id":"https://openalex.org/S56808608","display_name":"Biopolymers","issn_l":"0006-3525","issn":["0006-3525","1097-0282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"journal-article"},{"id":"pmid:1851045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1851045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopolymers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3362229202","display_name":"CONFORMATION OF MITOGENIC PEPTIDE GROWTH FACTORS","funder_award_id":"R29DK038676","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4140519180","display_name":"CONFORMATIONS OF INSULIN &ITS RECEPTOR COMPLEXES","funder_award_id":"R01DK020357","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7982940455","display_name":"DNA/RNA G-Quadruplexes: Structures, Transitions and Recognition","funder_award_id":"R01GM034504","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1499962425","https://openalex.org/W1589810575","https://openalex.org/W1619326219","https://openalex.org/W1656714822","https://openalex.org/W1967082228","https://openalex.org/W1968191853","https://openalex.org/W1979610587","https://openalex.org/W1979860617","https://openalex.org/W1982347187","https://openalex.org/W1989739192","https://openalex.org/W1990367089","https://openalex.org/W1990885130","https://openalex.org/W1995412269","https://openalex.org/W1997208628","https://openalex.org/W1998533627","https://openalex.org/W2002537095","https://openalex.org/W2002767280","https://openalex.org/W2004271773","https://openalex.org/W2014408390","https://openalex.org/W2018996043","https://openalex.org/W2019731175","https://openalex.org/W2025842644","https://openalex.org/W2039556954","https://openalex.org/W2051340923","https://openalex.org/W2058293114","https://openalex.org/W2061128078","https://openalex.org/W2062697216","https://openalex.org/W2064552314","https://openalex.org/W2067245150","https://openalex.org/W2072010950","https://openalex.org/W2083958255","https://openalex.org/W2108557355","https://openalex.org/W2113358853","https://openalex.org/W2127439444","https://openalex.org/W2127836998","https://openalex.org/W2213681588","https://openalex.org/W2326540817","https://openalex.org/W2952639157","https://openalex.org/W3005061426"],"related_works":["https://openalex.org/W1990885130","https://openalex.org/W175290290","https://openalex.org/W1656714822","https://openalex.org/W2100878960","https://openalex.org/W2060537650","https://openalex.org/W2064754959","https://openalex.org/W2043642866","https://openalex.org/W2037167408","https://openalex.org/W2331610909","https://openalex.org/W2078701345"],"abstract_inverted_index":{"Heteronuclear":[0],"multispin":[1],"coherence":[2],"proton-detected":[3],"two-dimensional":[4,66],"nmr":[5,67],"spectroscopic":[6],"experiments":[7],"were":[8,52],"used":[9],"to":[10,40,58,100],"obtain":[11],"information":[12],"on":[13,43,62],"protonated":[14],"carbons":[15],"and":[16,22,26,46],"nitrogens":[17],"of":[18,37,49,94],"the":[19,28,44,50,55,77],"self-complementary":[20],"d(G-G-T-A-T-A-C-C)":[21],"d(G-G-A-A-T-T-C-C)":[23],"duplexes,":[24],"with":[25],"without":[27],"drug":[29],"netropsin":[30],"dissolved":[31],"in":[32,96],"aqueous":[33],"solution.":[34],"Many":[35],"correlations":[36],"protons":[38],"coupled":[39],"13C":[41],"nuclei":[42],"base":[45],"sugar":[47],"rings":[48],"octanucleotides":[51],"detected,":[53],"allowing":[54],"carbon":[56],"resonances":[57],"be":[59,74,91],"assigned":[60],"based":[61],"previous":[63,81],"homonuclear":[64],"proton":[65,78],"studies.":[68],"Imino":[69,87],"nitrogen":[70,88],"assignments":[71,79],"can":[72],"also":[73],"made":[75],"using":[76],"from":[80],"one-dimensional":[82],"nuclear":[83],"overhauser":[84],"effect":[85],"experiments.":[86],"shifts":[89],"may":[90],"useful":[92],"indicators":[93],"changes":[95],"local":[97],"hydrogen-bonding":[98],"interactions":[99],"base-pair":[101],"edges.":[102]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}