{"id":"https://openalex.org/W2023217604","doi":"https://doi.org/10.1111/j.1349-7006.2006.00292.x","title":"Induction of cell apoptosis in non\u2010small cell lung cancer cells by cyclin A1 small interfering RNA","display_name":"Induction of cell apoptosis in non\u2010small cell lung cancer cells by cyclin A1 small interfering RNA","publication_year":2006,"publication_date":"2006-08-29","ids":{"openalex":"https://openalex.org/W2023217604","doi":"https://doi.org/10.1111/j.1349-7006.2006.00292.x","mag":"2023217604","pmid":"https://pubmed.ncbi.nlm.nih.gov/16984381","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11158377"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.2006.00292.x","doi":"https://doi.org/10.1111/j.1349-7006.2006.00292.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2006.00292.x","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11158377/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107824552","display_name":"Nam Hoon Cho","orcid":"https://orcid.org/0000-0002-0045-6441","observed_orcids":["https://orcid.org/0000-0002-0045-6441"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Nam Hoon Cho","raw_affiliation_strings":["Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. cho1988@yumc.yonsei.ac.kr","Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul","Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. cho1988@yumc.yonsei.ac.kr","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109918137","display_name":"Yoon Pyo Choi","orcid":"https://orcid.org/0000-0001-6229-5818","observed_orcids":["https://orcid.org/0000-0001-6229-5818"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon Pyo Choi","raw_affiliation_strings":["Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul","Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034650529","display_name":"Dong Suk Moon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Suk Moon","raw_affiliation_strings":["Department of Chest Surgery, Kwandong Myunggi Medical University, 411-706, Koyang, Kyunggi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chest Surgery, Kwandong Myunggi Medical University, 411-706, Koyang, Kyunggi","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032641605","display_name":"Haeryoung Kim","orcid":"https://orcid.org/0000-0002-4205-9081","observed_orcids":["https://orcid.org/0000-0002-4205-9081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haeryoung Kim","raw_affiliation_strings":["Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027048462","display_name":"Suki Kang","orcid":"https://orcid.org/0000-0002-9957-3479","observed_orcids":["https://orcid.org/0000-0002-9957-3479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suki Kang","raw_affiliation_strings":["Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041281117","display_name":"Owen Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Owen Ding","raw_affiliation_strings":["Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul","Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024676627","display_name":"Sun Young Rha","orcid":"https://orcid.org/0000-0002-2512-4531","observed_orcids":["https://orcid.org/0000-0002-2512-4531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun Young Rha","raw_affiliation_strings":["Department of Medical Oncology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113581497","display_name":"Yeon Ju Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon Ju Yang","raw_affiliation_strings":["Cancer Metastasis Research Center, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Metastasis Research Center, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 120-752, Seoul, Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082152746","display_name":"Sang-Ho Cho","orcid":"https://orcid.org/0000-0001-5590-1904","observed_orcids":["https://orcid.org/0000-0001-5590-1904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sang Ho Cho","raw_affiliation_strings":["Department of Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107824552"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":null,"fwci":1.1223,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77870096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"10","first_page":"1082","last_page":"1092"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-a1","display_name":"cyclin A1","score":1.0},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.765999972820282},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cdc2","display_name":"cdc2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.6299999952316284},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/extrinsic-apoptotic-pathway","display_name":"extrinsic apoptotic pathway","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.7962368726730347},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.7181124091148376},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.6937258839607239},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6451928019523621},{"id":"https://openalex.org/C28179978","wikidata":"https://www.wikidata.org/wiki/Q5198263","display_name":"Cyclin A2","level":5,"score":0.5978541374206543},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.5973913669586182},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.5969144105911255},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5925429463386536},{"id":"https://openalex.org/C2780360765","wikidata":"https://www.wikidata.org/wiki/Q5198275","display_name":"Cyclin E1","level":5,"score":0.5264571309089661},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.4798857271671295},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47536033391952515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4745265543460846},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.4226025938987732},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42002102732658386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3895537853240967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24507620930671692},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13427424430847168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07738521695137024}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019925","descriptor_name":"Cyclin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056750","descriptor_name":"Cyclin A1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1349-7006.2006.00292.x","doi":"https://doi.org/10.1111/j.1349-7006.2006.00292.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.2006.00292.x","pdf_url":null,"source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmid:16984381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16984381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11158377","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11158377/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/109038","doi":null,"is_oa":true,"landing_page_url":"http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2006.00292.x/abstract","pdf_url":"http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2006.00292.x/abstract","source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11158377","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11158377/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318846","display_name":"Yuhan","ror":"https://ror.org/00bv1jr75"},{"id":"https://openalex.org/F4320321314","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96"},{"id":"https://openalex.org/F4320335295","display_name":"Yonsei University College of Medicine","ror":"https://ror.org/01wjejq96"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2023217604.pdf","grobid_xml":"https://content.openalex.org/works/W2023217604.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W126084106","https://openalex.org/W1496415998","https://openalex.org/W1506799832","https://openalex.org/W1520664789","https://openalex.org/W1544564404","https://openalex.org/W1546820826","https://openalex.org/W1552046925","https://openalex.org/W1934425437","https://openalex.org/W1950719160","https://openalex.org/W1965336678","https://openalex.org/W1967642652","https://openalex.org/W1974069821","https://openalex.org/W1983942187","https://openalex.org/W1993151533","https://openalex.org/W2004812096","https://openalex.org/W2015943575","https://openalex.org/W2016034696","https://openalex.org/W2019667426","https://openalex.org/W2022306557","https://openalex.org/W2024095574","https://openalex.org/W2031376669","https://openalex.org/W2034309045","https://openalex.org/W2037023588","https://openalex.org/W2070127738","https://openalex.org/W2076249094","https://openalex.org/W2078879108","https://openalex.org/W2097786201","https://openalex.org/W2100668965","https://openalex.org/W2102633043","https://openalex.org/W2110846716","https://openalex.org/W2113164364","https://openalex.org/W2132997630","https://openalex.org/W2134864870","https://openalex.org/W2136570275","https://openalex.org/W2149126931","https://openalex.org/W2149950432","https://openalex.org/W2150505696","https://openalex.org/W2155612281","https://openalex.org/W2164660906","https://openalex.org/W2211020944"],"related_works":["https://openalex.org/W2941190909","https://openalex.org/W3029411590","https://openalex.org/W2087893067","https://openalex.org/W2035153010","https://openalex.org/W1991535475","https://openalex.org/W1838275596","https://openalex.org/W2972757197","https://openalex.org/W2130758161","https://openalex.org/W2116798585","https://openalex.org/W2339387787"],"abstract_inverted_index":{"Cyclin":[0,19],"A1":[1,20,37,62,108],"and":[2,38,55,72,84,96],"cyclin":[3,36,39,61,69,107],"B1":[4,40],"are":[5,11],"overexpressed":[6],"in":[7,16,48,64],"various":[8],"tumors":[9],"but":[10],"present":[12],"at":[13],"low":[14],"levels":[15],"normal":[17],"tissues.":[18],"is":[21],"restricted":[22],"to":[23,30,116],"germ":[24],"cells":[25],"undergoing":[26],"meiosis.":[27],"In":[28],"order":[29],"explore":[31],"the":[32],"possibility":[33],"of":[34,91],"using":[35,57],"as":[41],"anticancer":[42,113],"targets,":[43],"we":[44],"knocked":[45],"them":[46],"down":[47],"two":[49],"lung":[50,65,117],"cancer":[51,66],"cell":[52,67],"lines,":[53,68],"H157":[54],"H596,":[56],"siRNA.":[58],"As":[59],"with":[60,98],"siRNA":[63],"B1,":[70],"Cdc2":[71],"CDK2":[73],"were":[74],"all":[75],"significantly":[76],"downregulated.":[77],"The":[78],"S":[79],"phase":[80],"fraction":[81],"increased":[82],"significantly,":[83],"they":[85],"eventually":[86],"underwent":[87],"apoptosis":[88],"by":[89],"way":[90],"downregulated":[92],"intrinsic":[93],"apoptotic":[94,101],"pathways":[95],"modulators":[97],"upregulated":[99],"extrinsic":[100],"pathways.":[102],"Our":[103],"study":[104],"suggests":[105],"that":[106],"might":[109],"be":[110],"a":[111],"promising":[112],"target":[114],"specific":[115],"cancer.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}