{"id":"https://openalex.org/W2023061657","doi":"https://doi.org/10.1158/0008-5472.can-03-1786","title":"Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy","display_name":"Adeno-Associated Virus 2-Mediated Antiangiogenic Cancer Gene Therapy","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2023061657","doi":"https://doi.org/10.1158/0008-5472.can-03-1786","mag":"2023061657","pmid":"https://pubmed.ncbi.nlm.nih.gov/14996740"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-03-1786","doi":"https://doi.org/10.1158/0008-5472.can-03-1786","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-03-1786","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017420879","display_name":"Selvarangan Ponnazhagan","orcid":"https://orcid.org/0000-0001-5219-8379","observed_orcids":["https://orcid.org/0000-0001-5219-8379"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selvarangan Ponnazhagan","raw_affiliation_strings":["1Pathology and Departments of","Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology and Departments of","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055203521","display_name":"Gandham Mahendra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gandham Mahendra","raw_affiliation_strings":["1Pathology and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080151888","display_name":"Sanjay Kumar","orcid":"https://orcid.org/0000-0002-6568-1148","observed_orcids":["https://orcid.org/0000-0002-6568-1148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjay Kumar","raw_affiliation_strings":["1Pathology and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108535722","display_name":"Denise R. Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise R. Shaw","raw_affiliation_strings":["2Medicine and the Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medicine and the Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058987373","display_name":"Cecil R. Stockard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecil R. Stockard","raw_affiliation_strings":["1Pathology and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology and Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["1Pathology and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pathology and Departments of","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024420238","display_name":"Sreelatha Meleth","orcid":"https://orcid.org/0000-0001-7149-8262","observed_orcids":["https://orcid.org/0000-0001-7149-8262"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sreelatha Meleth","raw_affiliation_strings":["2Medicine and the Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama","GOBOT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medicine and the Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"GOBOT","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1245,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.92814459,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"5","first_page":"1781","last_page":"1787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus-2","display_name":"adeno-associated virus type 2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antiangiogenic-gene-therapy","display_name":"antiangiogenic gene therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/angiostatin","display_name":"angiostatin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/endostatin","display_name":"endostatin","score":1.0},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-neovasculature","display_name":"tumor neovasculature","score":0.8029999732971191},{"id":"https://openalex.org/keywords/sustained-transgene-expression","display_name":"sustained transgene expression","score":0.7049999833106995},{"id":"https://openalex.org/keywords/combination-gene-therapy","display_name":"combination gene therapy","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.47099998593330383},{"id":"https://openalex.org/keywords/adjuvant-cancer-therapy","display_name":"adjuvant cancer therapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-xenograft-models","display_name":"tumor xenograft models","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C106812560","wikidata":"https://www.wikidata.org/wiki/Q2063189","display_name":"Angiostatin","level":3,"score":0.980675220489502},{"id":"https://openalex.org/C75920679","wikidata":"https://www.wikidata.org/wiki/Q359012","display_name":"Endostatin","level":3,"score":0.9252339601516724},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6811808347702026},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6789675354957581},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6189450621604919},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.6169376373291016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5079677700996399},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5066012144088745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4703020453453064},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4613073170185089},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4384118318557739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3668517470359802},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.25901103019714355},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1858818233013153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.182521253824234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1613141894340515},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043168","descriptor_name":"Angiostatins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D043168","descriptor_name":"Angiostatins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-03-1786","doi":"https://doi.org/10.1158/0008-5472.can-03-1786","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-03-1786","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:14996740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14996740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G338997277","display_name":null,"funder_award_id":"5P50 CA 8359","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5132814139","display_name":"Gene Therapy for Prostate Cancer","funder_award_id":"R01CA098817","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5585402700","display_name":"Novel dendritic cell therapy for human cancers","funder_award_id":"R01CA090850","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309078","display_name":"State of New Jersey Department of Health","ror":"https://ror.org/03kmrjq19"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W55352385","https://openalex.org/W1506302384","https://openalex.org/W1557349926","https://openalex.org/W1573363574","https://openalex.org/W1579297325","https://openalex.org/W1595979491","https://openalex.org/W1645009826","https://openalex.org/W1748809707","https://openalex.org/W1942870285","https://openalex.org/W1968431199","https://openalex.org/W1971832103","https://openalex.org/W1983376387","https://openalex.org/W1989429684","https://openalex.org/W1996626361","https://openalex.org/W2001375090","https://openalex.org/W2003775813","https://openalex.org/W2006274666","https://openalex.org/W2007854533","https://openalex.org/W2009310029","https://openalex.org/W2013044761","https://openalex.org/W2015433718","https://openalex.org/W2023827769","https://openalex.org/W2026621524","https://openalex.org/W2035591620","https://openalex.org/W2037273213","https://openalex.org/W2050239255","https://openalex.org/W2051159468","https://openalex.org/W2059983738","https://openalex.org/W2059992425","https://openalex.org/W2071602601","https://openalex.org/W2072928113","https://openalex.org/W2073308580","https://openalex.org/W2086619383","https://openalex.org/W2101217334","https://openalex.org/W2105669313","https://openalex.org/W2108786375","https://openalex.org/W2131623878","https://openalex.org/W2131798870","https://openalex.org/W2134124671","https://openalex.org/W2138490954","https://openalex.org/W2151619744","https://openalex.org/W2152639592","https://openalex.org/W2158743409","https://openalex.org/W2166094737","https://openalex.org/W2172782937","https://openalex.org/W2313434580","https://openalex.org/W2317537028","https://openalex.org/W2325441863","https://openalex.org/W2410606281","https://openalex.org/W2413007786"],"related_works":["https://openalex.org/W2071602601","https://openalex.org/W1495803526","https://openalex.org/W2143321740","https://openalex.org/W2035472160","https://openalex.org/W1571321624","https://openalex.org/W2048298195","https://openalex.org/W1978929016","https://openalex.org/W2109881048","https://openalex.org/W2172782937","https://openalex.org/W2019210828"],"abstract_inverted_index":{"Angiogenesis":[0],"is":[1],"characteristic":[2],"of":[3,18,32,35,68,104,115,143,165,176],"solid":[4],"tumor":[5,19,39,52,95],"growth":[6],"and":[7,24,73,101,107,119,145,168,181],"a":[8,93,150,155],"surrogate":[9],"marker":[10],"for":[11,42],"metastasis":[12],"in":[13,37,92,112,136,154,187],"many":[14],"human":[15],"cancers.":[16],"Inhibition":[17],"angiogenesis":[20],"using":[21],"antiangiogenic":[22,47,70],"drugs":[23],"gene":[25,84,147],"transfer":[26,148],"approaches":[27],"has":[28],"suggested":[29],"the":[30,49,69,116,141],"potential":[31],"this":[33],"form":[34],"therapy":[36],"controlling":[38,51],"growth.":[40],"However,":[41],"long-term":[43,163],"tumor-free":[44],"survival":[45],"by":[46,78,111,120],"therapy,":[48],"factors":[50,71],"neovasculature":[53],"need":[54],"to":[55,138],"be":[56],"systemically":[57],"maintained":[58],"at":[59],"stable":[60],"therapeutic":[61],"levels.":[62],"Here":[63],"we":[64],"show":[65],"sustained":[66],"expression":[67,164],"angiostatin":[72,106,133,146,169],"endostatin":[74,108,131,144,167],"as":[75],"secretory":[76],"proteins":[77],"recombinant":[79],"adeno-associated":[80],"virus":[81],"2":[82],"(rAAV)-mediated":[83],"transfer.":[85],"Both":[86],"vectors":[87],"provided":[88],"significant":[89,139],"protective":[90],"efficacy":[91],"mouse":[94],"xenograft":[96],"model.":[97],"Stable":[98],"transgene":[99],"persistence":[100],"systemic":[102],"levels":[103],"both":[105,166],"were":[109],"confirmed":[110],"situ":[113],"hybridization":[114],"vector-injected":[117],"tissues":[118],"serum":[121],"ELISA":[122],"measurements,":[123],"respectively.":[124],"Whereas":[125],"treatment":[126],"with":[127,189],"rAAV":[128],"containing":[129],"either":[130],"or":[132,191],"alone":[134],"resulted":[135,153],"moderate":[137],"protection,":[140],"combination":[142,188],"from":[149],"single":[151],"vector":[152],"complete":[156],"protection.":[157],"These":[158],"data":[159],"suggest":[160],"that":[161],"AAV-mediated":[162],"may":[170,182],"have":[171],"clinical":[172],"utility":[173],"against":[174],"recurrence":[175],"cancers":[177],"after":[178],"primary":[179],"therapies":[180,186],"represent":[183],"rational":[184],"adjuvant":[185],"radiation":[190],"chemotherapy.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
