{"id":"https://openalex.org/W2022998640","doi":"https://doi.org/10.1002/art.20439","title":"The V\u03bb\u2013J\u03bb repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoire","display_name":"The V\u03bb\u2013J\u03bb repertoire of patients with systemic lupus erythematosus manifests characteristics of the natural antibody repertoire","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W2022998640","doi":"https://doi.org/10.1002/art.20439","mag":"2022998640","pmid":"https://pubmed.ncbi.nlm.nih.gov/15334475"},"language":"en","primary_location":{"id":"doi:10.1002/art.20439","doi":"https://doi.org/10.1002/art.20439","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.20439","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100349137","display_name":"Jisoo Lee","orcid":"https://orcid.org/0000-0001-6279-7025","observed_orcids":["https://orcid.org/0000-0001-6279-7025","https://orcid.org/0000-0002-6172-8383","https://orcid.org/0009-0002-1695-0433"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jisoo Lee","raw_affiliation_strings":["Ewha Women's University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ewha Women's University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046493269","display_name":"Young-Joo Cho","orcid":"https://orcid.org/0000-0002-9414-5934","observed_orcids":["https://orcid.org/0000-0002-9414-5934"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Joo Cho","raw_affiliation_strings":["Ewha Women's University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ewha Women's University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter E. Lipsky","raw_affiliation_strings":["National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5507,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81353573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"50","issue":"8","first_page":"2604","last_page":"2614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/lambda-light-chain","display_name":"lambda light chain","score":0.7129999995231628},{"id":"https://openalex.org/keywords/natural-autoantibodies","display_name":"natural autoantibodies","score":0.7960000038146973},{"id":"https://openalex.org/keywords/autoantibody-production","display_name":"autoantibody production","score":0.8759999871253967},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cd5-b-cells","display_name":"CD5+ B cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/junctional-diversity","display_name":"junctional diversity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.7693250775337219},{"id":"https://openalex.org/C113067387","wikidata":"https://www.wikidata.org/wiki/Q14912836","display_name":"CD5","level":3,"score":0.6574617624282837},{"id":"https://openalex.org/C2910693471","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody Repertoire","level":3,"score":0.6395142078399658},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6000299453735352},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4942953586578369},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.49405768513679504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49345436692237854},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.4824298322200775},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.44857582449913025},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.43704575300216675},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4077310562133789},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26842254400253296},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06523415446281433},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007144","descriptor_name":"Immunoglobulin J-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007146","descriptor_name":"Immunoglobulin lambda-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007147","descriptor_name":"Immunoglobulin Light Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015322","descriptor_name":"Gene Rearrangement, B-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.20439","doi":"https://doi.org/10.1002/art.20439","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.20439","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:15334475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15334475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W180872527","https://openalex.org/W1482733938","https://openalex.org/W1488045575","https://openalex.org/W1524023204","https://openalex.org/W1551661075","https://openalex.org/W1552738427","https://openalex.org/W1565517226","https://openalex.org/W1597017834","https://openalex.org/W1603837048","https://openalex.org/W1637561808","https://openalex.org/W1900560511","https://openalex.org/W1919334117","https://openalex.org/W1922805044","https://openalex.org/W1923365985","https://openalex.org/W1956586550","https://openalex.org/W1968757041","https://openalex.org/W1977993700","https://openalex.org/W1980713412","https://openalex.org/W2004054985","https://openalex.org/W2004879566","https://openalex.org/W2007412943","https://openalex.org/W2010868937","https://openalex.org/W2016208323","https://openalex.org/W2016913945","https://openalex.org/W2044310955","https://openalex.org/W2045417932","https://openalex.org/W2054080837","https://openalex.org/W2059383814","https://openalex.org/W2068778488","https://openalex.org/W2070527591","https://openalex.org/W2072415380","https://openalex.org/W2073022345","https://openalex.org/W2098497060","https://openalex.org/W2102566053","https://openalex.org/W2108579454","https://openalex.org/W2116592902","https://openalex.org/W2128904113","https://openalex.org/W2129678357","https://openalex.org/W2130171394","https://openalex.org/W2134544592","https://openalex.org/W2145700736","https://openalex.org/W2164964449","https://openalex.org/W2166451951","https://openalex.org/W4313341505","https://openalex.org/W4313347827"],"related_works":["https://openalex.org/W4313347827","https://openalex.org/W2145700736","https://openalex.org/W7095835704","https://openalex.org/W1488065622","https://openalex.org/W2108579454","https://openalex.org/W1775259803","https://openalex.org/W3085903250","https://openalex.org/W2067977668","https://openalex.org/W1993466906","https://openalex.org/W7096444893"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"understand":[2],"in":[3,10,38,58,143,201],"detail":[4,59],"the":[5,23,35,61,100,123,127,130,144,146,152,202,229,237,259],"mechanisms":[6],"of":[7,22,46,64,103,116,126,166,179,191,214,243,261],"autoantibody":[8],"production":[9,260],"patients":[11,53,118,153],"with":[12,34,60,122,154,160,170,194],"systemic":[13],"lupus":[14],"erythematosus":[15],"(SLE),":[16],"we":[17],"performed":[18],"a":[19,176],"comprehensive":[20],"analysis":[21],"normal":[24,81,89,244],"human":[25,71],"immunoglobulin":[26],"light":[27],"chain":[28,109],"V(lambda)":[29,36,44,62,114,136,192,223],"repertoire":[30,37,45,63,115,125,240],"and":[31,56,74,129,139,151,183,206,221,247],"compared":[32,57],"it":[33],"SLE":[39,43,52,117,184,207,222,238],"patients.":[40],"METHODS:":[41],"The":[42,112,135,156],"B":[47,66,76,85,105,133,149,185,208,218,249],"cells":[48,67,77,86,106],"obtained":[49,68,78,87],"from":[50,69,79,88,99],"3":[51,70],"was":[54,175,199],"analyzed":[55],"IgM+":[65],"fetal":[72,248],"spleens":[73],"IgM+,CD5+":[75,246],"2":[80],"adults.":[82],"Conventional":[83],"IgM+,CD5-":[84],"adults":[90],"were":[91,97,141],"used":[92],"as":[93],"controls.":[94],"V(lambda)-J(lambda)":[95,230,239],"rearrangements":[96,159],"amplified":[98],"genomic":[101],"DNA":[102],"individual":[104],"by":[107,164],"polymerase":[108],"reaction.":[110],"RESULTS:":[111],"expressed":[113,124],"contained":[119],"several":[120],"similarities":[121],"fetus":[128],"adult":[131,147,181,203,216,245],"CD5+":[132,148,217],"cells.":[134],"genes":[137],"3L":[138],"1G":[140],"overexpressed":[142],"fetus,":[145],"cells,":[150,219],"SLE.":[155],"selection":[157],"for":[158,258],"restricted":[161],"junctional":[162],"diversity":[163],"utilization":[165],"homology-mediated":[167,226],"joining,":[168],"together":[169],"diminished":[171],"N":[172],"nucleotide":[173],"addition,":[174],"prominent":[177],"feature":[178],"fetal,":[180,205,220],"CD5+,":[182,204],"cell":[186,209,250],"repertoires.":[187,210],"Furthermore,":[188],"profound":[189],"expansion":[190],"clones":[193,224],"identical":[195],"third":[196],"complementarity-determining":[197],"regions":[198],"observed":[200],"Notably,":[211],"significant":[212],"numbers":[213],"expanded":[215],"utilized":[225],"joining":[227],"at":[228],"junctions.":[231],"CONCLUSION:":[232],"These":[233],"data":[234],"demonstrate":[235],"that":[236,252],"manifests":[241],"characteristics":[242],"populations":[251],"are":[253],"known":[254],"to":[255],"be":[256],"enriched":[257],"natural":[262],"autoantibodies.":[263]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
