{"id":"https://openalex.org/W2022983553","doi":"https://doi.org/10.1016/0006-8993(93)90492-6","title":"Sleep-wake disturbances in an animal model of chronic cholinergic insufficiency","display_name":"Sleep-wake disturbances in an animal model of chronic cholinergic insufficiency","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2022983553","doi":"https://doi.org/10.1016/0006-8993(93)90492-6","mag":"2022983553","pmid":"https://pubmed.ncbi.nlm.nih.gov/7904530"},"language":"en","primary_location":{"id":"doi:10.1016/0006-8993(93)90492-6","doi":"https://doi.org/10.1016/0006-8993(93)90492-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(93)90492-6","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060383124","display_name":"Ronald S. Szymusiak","orcid":"https://orcid.org/0000-0001-7193-1943","observed_orcids":["https://orcid.org/0000-0001-7193-1943"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210145304","display_name":"VA Sepulveda Ambulatory Care Center","ror":"https://ror.org/04zdeh149","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210145304","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald Szymusiak","raw_affiliation_strings":["Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, Sepulveda, CA 91343","Departments of Anatomy & Cell Biology, University of California, Los Angeles, CA, USA","Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, 16111 Plummer St., Sepulveda CA 91343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, Sepulveda, CA 91343","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210145304"]},{"raw_affiliation_string":"Departments of Anatomy & Cell Biology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, 16111 Plummer St., Sepulveda CA 91343, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210145304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113902795","display_name":"Dennis McGinty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210145304","display_name":"VA Sepulveda Ambulatory Care Center","ror":"https://ror.org/04zdeh149","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210145304","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis McGinty","raw_affiliation_strings":["Psychology, University of California, Los Angeles, CA, USA","Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, 16111 Plummer St., Sepulveda CA 91343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, 16111 Plummer St., Sepulveda CA 91343, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210145304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047735101","display_name":"Matthew Fairchild","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210145304","display_name":"VA Sepulveda Ambulatory Care Center","ror":"https://ror.org/04zdeh149","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210145304","https://openalex.org/I4210156876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. David Fairchild","raw_affiliation_strings":["Pharmacology, School of Medicine, University of California, Los Angeles, CA, USA","Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, 16111 Plummer St., Sepulveda CA 91343, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, School of Medicine, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Sleep Physiology Laboratory (151A3), Department of Veterans Affairs Medical Center, 16111 Plummer St., Sepulveda CA 91343, USA","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210145304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078952307","display_name":"Donald J. Jenden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald J. Jenden","raw_affiliation_strings":["Pharmacology, School of Medicine, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology, School of Medicine, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060383124"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I161318765","https://openalex.org/I4210145304"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.1842,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.46385761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"629","issue":"1","first_page":"141","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-wake-disturbances","display_name":"sleep-wake disturbances","score":0.7879999876022339},{"id":"https://openalex.org/keywords/rem-sleep","display_name":"REM sleep","score":0.7910000085830688},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.996999979019165},{"id":"https://openalex.org/keywords/wakefulness","display_name":"wakefulness","score":0.6259999871253967},{"id":"https://openalex.org/keywords/light-dark-cycle","display_name":"light-dark cycle","score":0.6190000176429749},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.8123222589492798},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.7397603988647461},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7182027101516724},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.7055823802947998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6814457178115845},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.580872654914856},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.5218763947486877},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.476574182510376},{"id":"https://openalex.org/C2779213384","wikidata":"https://www.wikidata.org/wiki/Q211402","display_name":"Rapid eye movement sleep","level":3,"score":0.4436802268028259},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36760878562927246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33443766832351685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32990026473999023},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31085801124572754},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.15803635120391846},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002796","descriptor_name":"Choline Deficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012895","descriptor_name":"Sleep, REM","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-8993(93)90492-6","doi":"https://doi.org/10.1016/0006-8993(93)90492-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-8993(93)90492-6","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:7904530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7904530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3195081290","display_name":"INTERACTION OF DRUGS WITH BRAIN ACETYLCHOLINE","funder_award_id":"R01MH017691","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W103113309","https://openalex.org/W1588053646","https://openalex.org/W1703472577","https://openalex.org/W1989032031","https://openalex.org/W1999959551","https://openalex.org/W2000206451","https://openalex.org/W2021042357","https://openalex.org/W2023586401","https://openalex.org/W2025821577","https://openalex.org/W2037744486","https://openalex.org/W2055904512","https://openalex.org/W2060112762","https://openalex.org/W2060163004","https://openalex.org/W2061763366","https://openalex.org/W2064532781","https://openalex.org/W2084698758","https://openalex.org/W2135533841","https://openalex.org/W2145321763","https://openalex.org/W2172788585","https://openalex.org/W2233915903","https://openalex.org/W2411075130"],"related_works":["https://openalex.org/W2413815200","https://openalex.org/W2023586401","https://openalex.org/W2046644571","https://openalex.org/W2075668332","https://openalex.org/W2013979092","https://openalex.org/W2763517608","https://openalex.org/W1517903621","https://openalex.org/W1975928460","https://openalex.org/W2045815714","https://openalex.org/W2037744486"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}