{"id":"https://openalex.org/W2022978758","doi":"https://doi.org/10.1371/journal.pone.0030541","title":"DNA Repair in Human Pluripotent Stem Cells Is Distinct from That in Non-Pluripotent Human Cells","display_name":"DNA Repair in Human Pluripotent Stem Cells Is Distinct from That in Non-Pluripotent Human Cells","publication_year":2012,"publication_date":"2012-03-06","ids":{"openalex":"https://openalex.org/W2022978758","doi":"https://doi.org/10.1371/journal.pone.0030541","mag":"2022978758","pmid":"https://pubmed.ncbi.nlm.nih.gov/22412831","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3295811"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0030541","doi":"https://doi.org/10.1371/journal.pone.0030541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030541","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030541&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030541&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084736794","display_name":"Li Luo","orcid":"https://orcid.org/0000-0002-8680-4119","observed_orcids":["https://orcid.org/0000-0002-8680-4119"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Z. Luo","raw_affiliation_strings":["Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063564060","display_name":"Sailesh Gopalakrishna-Pillai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sailesh Gopalakrishna-Pillai","raw_affiliation_strings":["Department of Stem Cell Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079813729","display_name":"Stephanie L. Nay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie L. Nay","raw_affiliation_strings":["Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698573","display_name":"Sang\u2010Won Park","orcid":"https://orcid.org/0000-0002-0550-1897","observed_orcids":["https://orcid.org/0000-0002-0550-1897"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang-Won Park","raw_affiliation_strings":["Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077050376","display_name":"Steven Bates","orcid":"https://orcid.org/0000-0003-0489-5705","observed_orcids":["https://orcid.org/0000-0003-0489-5705"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Bates","raw_affiliation_strings":["Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102153977","display_name":"Xianmin Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianmin Zeng","raw_affiliation_strings":["North Bay CIRM Shared Research Laboratory for Stem Cells and Aging, Buck Institute for Age Research, Novato, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Bay CIRM Shared Research Laboratory for Stem Cells and Aging, Buck Institute for Age Research, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108492681","display_name":"Linda E. Iverson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda E. Iverson","raw_affiliation_strings":["Department of Stem Cell Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035390675","display_name":"Timothy R O'Connor","orcid":"https://orcid.org/0000-0001-5848-3592","observed_orcids":["https://orcid.org/0000-0001-5848-3592"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy R. O'Connor","raw_affiliation_strings":["Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035390675"],"corresponding_institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6761,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91432146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"3","first_page":"e30541","last_page":"e30541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.14380000531673431,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nucleotide-excision-repair","display_name":"nucleotide excision repair","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.847000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.9340000152587891},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.9348773956298828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6535156965255737},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6179177761077881},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5564984083175659},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5227532386779785},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.49223247170448303},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.46813854575157166},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4266453683376312},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.416521281003952},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.4101332128047943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34041494131088257},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32885709404945374},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.22935330867767334},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22060567140579224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08590376377105713}],"mesh":[{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011740","descriptor_name":"Pyrimidine Dimers","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D013463","descriptor_name":"Sulfuric Acid Esters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0030541","doi":"https://doi.org/10.1371/journal.pone.0030541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030541","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030541&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3295811","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3295811","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22412831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22412831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.316","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/15/0a/pone.0030541.PMC3295811.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ee407c8d20324d3fa49ab870eff4364c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ee407c8d20324d3fa49ab870eff4364c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e30541 (2012)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt76t6f7f1","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/76t6f7f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE, vol 7, iss 3","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/128094","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/DNA_Repair_in_Human_Pluripotent_Stem_Cells_Is_Distinct_from_That_in_Non_Pluripotent_Human_Cells/128094","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0030541","doi":"https://doi.org/10.1371/journal.pone.0030541","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0030541","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030541&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4283778863","display_name":"City of Hope Lymphoma SPORE","funder_award_id":"P50CA107399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000889907","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA033572","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320309885","display_name":"California Institute of Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320310407","display_name":"Beckman Research Institute, City of Hope","ror":"https://ror.org/00w6g5w60"},{"id":"https://openalex.org/F4320310408","display_name":"Comprehensive Cancer Center, City of Hope","ror":"https://ror.org/00w6g5w60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022978758.pdf","grobid_xml":"https://content.openalex.org/works/W2022978758.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W80522390","https://openalex.org/W1269552450","https://openalex.org/W1499179356","https://openalex.org/W1531823089","https://openalex.org/W1575137033","https://openalex.org/W1965655477","https://openalex.org/W1971012430","https://openalex.org/W1973796414","https://openalex.org/W1974115274","https://openalex.org/W1974371729","https://openalex.org/W1974691766","https://openalex.org/W1976619282","https://openalex.org/W1977075613","https://openalex.org/W1977284533","https://openalex.org/W1981900473","https://openalex.org/W1982501879","https://openalex.org/W1987364221","https://openalex.org/W1987610133","https://openalex.org/W1987774343","https://openalex.org/W1990170308","https://openalex.org/W1990828107","https://openalex.org/W1996083284","https://openalex.org/W2000639651","https://openalex.org/W2014385950","https://openalex.org/W2015853472","https://openalex.org/W2017350087","https://openalex.org/W2019082839","https://openalex.org/W2022534144","https://openalex.org/W2027623197","https://openalex.org/W2028044172","https://openalex.org/W2030841684","https://openalex.org/W2037338370","https://openalex.org/W2037898576","https://openalex.org/W2042699407","https://openalex.org/W2049217916","https://openalex.org/W2050560941","https://openalex.org/W2052454337","https://openalex.org/W2054791794","https://openalex.org/W2059428532","https://openalex.org/W2061245152","https://openalex.org/W2061821048","https://openalex.org/W2062619573","https://openalex.org/W2065796189","https://openalex.org/W2071411482","https://openalex.org/W2072990456","https://openalex.org/W2074018558","https://openalex.org/W2075084906","https://openalex.org/W2079853060","https://openalex.org/W2084264548","https://openalex.org/W2091175914","https://openalex.org/W2092139028","https://openalex.org/W2095092396","https://openalex.org/W2099627146","https://openalex.org/W2100413563","https://openalex.org/W2106845421","https://openalex.org/W2110487265","https://openalex.org/W2115626825","https://openalex.org/W2117808727","https://openalex.org/W2122020045","https://openalex.org/W2126432370","https://openalex.org/W2127702552","https://openalex.org/W2128635872","https://openalex.org/W2135758906","https://openalex.org/W2137022580","https://openalex.org/W2139964075","https://openalex.org/W2142046859","https://openalex.org/W2154546296","https://openalex.org/W2157785989","https://openalex.org/W2158811885","https://openalex.org/W2160366468","https://openalex.org/W2161085054"],"related_works":["https://openalex.org/W7098523101","https://openalex.org/W93491728","https://openalex.org/W4205652989","https://openalex.org/W2254025460","https://openalex.org/W2061821048","https://openalex.org/W2883170327","https://openalex.org/W2080274817","https://openalex.org/W2007701240","https://openalex.org/W2030328183","https://openalex.org/W2982457185"],"abstract_inverted_index":{"The":[0],"potential":[1],"for":[2,113,190],"human":[3,7,49],"disease":[4],"treatment":[5],"using":[6],"pluripotent":[8,17,48,74,89,106,143,157,165,188,237],"stem":[9,13,18,50],"cells,":[10,75,82,131],"including":[11],"embryonic":[12],"cells":[14,19,51,107,134,144,158,166,176,189],"and":[15,61,101,140,211,251],"induced":[16,125],"(iPSCs),":[20],"also":[21],"carries":[22],"the":[23,179,184],"risk":[24],"of":[25,43,69,88,97,156,186,219],"added":[26],"genomic":[27,245],"instability.":[28],"Genomic":[29],"instability":[30,210],"is":[31,161],"most":[32],"often":[33],"linked":[34],"to":[35,58,78,137,150,159,231,242,248],"DNA":[36,70,85,110,171,191,213,221,233],"repair":[37,45,71,86,111,192,214,222,234],"deficiencies,":[38],"which":[39],"indicates":[40],"that":[41,84,119,142,177,200],"screening/characterization":[42],"possible":[44],"deficiencies":[46],"in":[47,73,80,129,216,236,240],"should":[52],"be":[53],"a":[54,67,146,202,229],"necessary":[55],"step":[56],"prior":[57,247],"their":[59,244,249],"clinical":[60,252],"research":[62],"use.":[63,253],"In":[64,182],"this":[65,138],"study,":[66],"comparison":[68],"pathways":[72,223],"as":[76],"compared":[77],"those":[79,96],"non-pluripotent":[81],"demonstrated":[83,201],"capacities":[87,112,215,235],"cell":[90,238],"lines":[91,99],"were":[92,102],"more":[93],"heterogeneous":[94],"than":[95,173],"differentiated":[98,133,175],"examined":[100],"generally":[103],"greater.":[104],"Although":[105],"had":[108,145],"high":[109],"nucleotide":[114],"excision":[115],"repair,":[116],"we":[117],"show":[118],"ultraviolet":[120,169],"radiation":[121],"at":[122],"low":[123],"fluxes":[124],"an":[126,197],"apoptotic":[127,148],"response":[128,136,149],"these":[130,226],"while":[132],"lacked":[135],"stimulus,":[139],"note":[141],"similar":[147],"alkylating":[151],"agent":[152],"damage.":[153],"This":[154],"sensitivity":[155],"damage":[160,172],"notable":[162],"since":[163],"viable":[164],"exhibit":[167],"less":[168],"light-induced":[170],"do":[174],"receive":[178],"same":[180],"flux.":[181],"addition,":[183],"importance":[185],"screening":[187],"defects":[193],"was":[194],"highlighted":[195],"by":[196],"iPSC":[198],"line":[199],"normal":[203],"spectral":[204],"karyotype,":[205],"but":[206],"showed":[207],"both":[208],"microsatellite":[209],"reduced":[212],"three":[217],"out":[218],"four":[220],"examined.":[224],"Together,":[225],"results":[227],"demonstrate":[228],"need":[230],"evaluate":[232],"lines,":[239],"order":[241],"characterize":[243],"stability,":[246],"pre-clinical":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}