{"id":"https://openalex.org/W2022965263","doi":"https://doi.org/10.1146/annurev.bi.49.070180.003455","title":"Repeated Genes in Eukaryotes","display_name":"Repeated Genes in Eukaryotes","publication_year":1980,"publication_date":"1980-06-01","ids":{"openalex":"https://openalex.org/W2022965263","doi":"https://doi.org/10.1146/annurev.bi.49.070180.003455","mag":"2022965263","pmid":"https://pubmed.ncbi.nlm.nih.gov/6996571"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.bi.49.070180.003455","doi":"https://doi.org/10.1146/annurev.bi.49.070180.003455","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.bi.49.070180.003455","pdf_url":null,"source":{"id":"https://openalex.org/S53860259","display_name":"Annual Review of Biochemistry","issn_l":"0066-4154","issn":["0066-4154","1545-4509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087340494","display_name":"Eric O. Long","orcid":"https://orcid.org/0000-0002-7793-3728","observed_orcids":["https://orcid.org/0000-0002-7793-3728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric O. Long","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor B. Dawid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":150.2254,"has_fulltext":false,"cited_by_count":1389,"citation_normalized_percentile":{"value":0.99985433,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"49","issue":"1","first_page":"727","last_page":"764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.6639999747276306},{"id":"https://openalex.org/keywords/eukaryotic-genome-evolution","display_name":"eukaryotic genome evolution","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.6930000185966492},{"id":"https://openalex.org/keywords/tissue-growth-regulation","display_name":"tissue growth regulation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.621999979019165},{"id":"https://openalex.org/keywords/organ-size-control","display_name":"organ size control","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.8151302337646484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6399630308151245},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5903173089027405},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.5687915086746216},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5556405782699585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5430455207824707},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.49018198251724243},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4533793032169342},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3733651638031006},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.362702876329422},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3383471369743347},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2336699664592743}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012320","descriptor_name":"RNA Polymerase III","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.bi.49.070180.003455","doi":"https://doi.org/10.1146/annurev.bi.49.070180.003455","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.bi.49.070180.003455","pdf_url":null,"source":{"id":"https://openalex.org/S53860259","display_name":"Annual Review of Biochemistry","issn_l":"0066-4154","issn":["0066-4154","1545-4509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biochemistry","raw_type":"journal-article"},{"id":"pmid:6996571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6996571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1966394554","https://openalex.org/W2004635656"],"related_works":["https://openalex.org/W2174240372","https://openalex.org/W2173706050","https://openalex.org/W2113665291","https://openalex.org/W2115494657","https://openalex.org/W2148132216","https://openalex.org/W2113055221","https://openalex.org/W2133221589","https://openalex.org/W4250863709","https://openalex.org/W3145802305","https://openalex.org/W2172620021"],"abstract_inverted_index":{"The":[0],"Hippo":[1],"pathway":[2],"was":[3],"initially":[4],"discovered":[5],"in":[6],"Drosophila":[7],"melanogaster":[8],"as":[9],"a":[10],"key":[11],"regulator":[12],"of":[13],"tissue":[14],"growth.":[15],"It":[16],"is":[17],"an":[18],"evolutionarily":[19],"conserved":[20],"signaling":[21],"cascade":[22],"regulating":[23],"numerous":[24],"biological":[25],"processes,":[26],"including":[27],"cell":[28],"growth":[29],"and":[30],"fate":[31],"decision,":[32],"organ":[33],"size":[34],"...Read":[35],"More":[36]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":34},{"year":2012,"cited_by_count":33}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}