{"id":"https://openalex.org/W2022950232","doi":"https://doi.org/10.1002/ijc.2910380616","title":"Retinoblastoma cell differentiation in culture","display_name":"Retinoblastoma cell differentiation in culture","publication_year":1986,"publication_date":"1986-12-15","ids":{"openalex":"https://openalex.org/W2022950232","doi":"https://doi.org/10.1002/ijc.2910380616","mag":"2022950232","pmid":"https://pubmed.ncbi.nlm.nih.gov/3025105"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910380616","doi":"https://doi.org/10.1002/ijc.2910380616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910380616","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004712081","display_name":"Emil Bogenmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emil Bogenmann","raw_affiliation_strings":["Division of Hematology-Oncology, Children's Hospital of Los Angeles, Los Angeles, CA 90027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Children's Hospital of Los Angeles, Los Angeles, CA 90027, USA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004712081"],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.4189,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.56120465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"6","first_page":"883","last_page":"887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.12110000103712082,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoblastoma","display_name":"retinoblastoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/photoreceptor-differentiation","display_name":"photoreceptor differentiation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tumor-cell-culture","display_name":"tumor cell culture","score":0.6919999718666077},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dibutyryl-camp","display_name":"dibutyryl cyclic AMP","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-ultrastructure","display_name":"cell ultrastructure","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cell-junctions","display_name":"cell junctions","score":0.6460000276565552},{"id":"https://openalex.org/keywords/basal-bodies","display_name":"basal bodies","score":0.5799999833106995},{"id":"https://openalex.org/keywords/cilia","display_name":"cilia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.5189999938011169},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.7593015432357788},{"id":"https://openalex.org/C48342290","wikidata":"https://www.wikidata.org/wiki/Q178355","display_name":"Centriole","level":3,"score":0.7349334955215454},{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.621491551399231},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.5976876616477966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5913865566253662},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5740911960601807},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5107929706573486},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5035657286643982},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.4895232915878296},{"id":"https://openalex.org/C131151476","wikidata":"https://www.wikidata.org/wiki/Q809753","display_name":"Basal body","level":4,"score":0.4785521626472473},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45758548378944397},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.418934166431427},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4124698340892792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32158714532852173},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24019664525985718},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.22181755304336548},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0900750458240509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08048132061958313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012175","descriptor_name":"Retinoblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012175","descriptor_name":"Retinoblastoma","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012397","descriptor_name":"Rosette Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910380616","doi":"https://doi.org/10.1002/ijc.2910380616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910380616","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:3025105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3025105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6735570968","display_name":null,"funder_award_id":"EY04950","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1482008785","https://openalex.org/W1778442814","https://openalex.org/W1980759225","https://openalex.org/W1986082682","https://openalex.org/W2006321839","https://openalex.org/W2053305620","https://openalex.org/W2067239811","https://openalex.org/W2082248375","https://openalex.org/W2135241184","https://openalex.org/W2147039086","https://openalex.org/W2162585993","https://openalex.org/W2263921479","https://openalex.org/W2271332419","https://openalex.org/W2416044576","https://openalex.org/W4301424126"],"related_works":["https://openalex.org/W2072171828","https://openalex.org/W2079259990","https://openalex.org/W1943860137","https://openalex.org/W4301424126","https://openalex.org/W2006321839","https://openalex.org/W2044380274","https://openalex.org/W2170335447","https://openalex.org/W105765519","https://openalex.org/W2167775456","https://openalex.org/W2474274483"],"abstract_inverted_index":{"Human":[0],"retinoblastoma":[1,77],"cells":[2,78,93],"were":[3,103,168],"grown":[4],"in":[5,25,38,55,90,106,114,122,125,142],"tissue":[6],"culture":[7],"and":[8,28,100,140,152,171],"their":[9,172],"differentiation":[10,21],"into":[11],"Flexner-Wintersteiner":[12,73],"rosettes":[13,89,95,112],"was":[14,22],"investigated.":[15],"This":[16],"process":[17],"of":[18,32,48,63,76,88,111,118,138,146,159,166],"photoreceptor":[19,162],"cell":[20,30,58,66,132],"only":[23],"observed":[24,105],"primary":[26],"cultures":[27],"subsequent":[29],"passages":[31],"tumors":[33],"which":[34],"showed":[35,116],"these":[36],"structures":[37],"vivo.":[39],"Rosettes":[40],"formed":[41,113],"spontaneously":[42],"within":[43,94],"5-9":[44],"d":[45],"after":[46],"plating":[47],"the":[49,64,86,119,143,147,160],"tumor":[50,57],"cells.":[51],"Under":[52],"optimal":[53],"conditions":[54],"certain":[56],"strains,":[59],"up":[60],"to":[61,79,97],"80%":[62],"cultured":[65],"aggregates":[67],"contained":[68],"one":[69],"or":[70,81],"more":[71],"differentiated":[72],"rosettes.":[74],"Exposure":[75],"RA":[80],"dcAMP":[82],"did":[83],"not":[84],"alter":[85],"number":[87],"culture.":[91],"Retinoblastoma":[92],"continued":[96],"synthesize":[98],"DNA,":[99],"mitotic":[101],"figures":[102],"frequently":[104],"histological":[107],"sections.":[108],"Ultrastructural":[109],"analysis":[110],"vitro":[115],"many":[117],"characteristics":[120],"described":[121],"those":[123],"found":[124,170],"vivo":[126],"including":[127],"a":[128],"polarized":[129],"shape,":[130],"established":[131],"junctions":[133],"(Zonula":[134],"adherens),":[135],"extensive":[136],"accumulation":[137],"mitochondria":[139],"microtubules":[141],"apical":[144],"part":[145],"cells,":[148],"numerous":[149],"basal":[150],"bodies":[151],"centrioles":[153],"as":[154,156],"well":[155],"cilia":[157],"typical":[158],"mature":[161],"cell.":[163],"Lamellated":[164],"stacks":[165],"membranes":[167],"also":[169],"nature":[173],"is":[174],"discussed.":[175]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}