{"id":"https://openalex.org/W2022936370","doi":"https://doi.org/10.4158/ep.17.6.906","title":"Efficacy of Anti Hyperglycemic Therapies and the Influence of Baseline Hemoglobin A1C: A Meta-Analysis of the Liraglutide Development Program","display_name":"Efficacy of Anti Hyperglycemic Therapies and the Influence of Baseline Hemoglobin A1C: A Meta-Analysis of the Liraglutide Development Program","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2022936370","doi":"https://doi.org/10.4158/ep.17.6.906","mag":"2022936370","pmid":"https://pubmed.ncbi.nlm.nih.gov/22193143"},"language":"en","primary_location":{"id":"doi:10.4158/ep.17.6.906","doi":"https://doi.org/10.4158/ep.17.6.906","is_oa":false,"landing_page_url":"https://doi.org/10.4158/ep.17.6.906","pdf_url":null,"source":{"id":"https://openalex.org/S165390330","display_name":"Endocrine Practice","issn_l":"1530-891X","issn":["1530-891X","1934-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Practice","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045462483","display_name":"Robert R. Henry","orcid":"https://orcid.org/0000-0002-4821-0117","observed_orcids":["https://orcid.org/0000-0002-4821-0117"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert R. Henry","raw_affiliation_strings":["University of California San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA. rrhenry@vapop.ucsd.edu","University of California San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA. rrhenry@vapop.ucsd.edu","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040182038","display_name":"John B. Buse","orcid":"https://orcid.org/0000-0002-9723-3876","observed_orcids":["https://orcid.org/0000-0002-9723-3876","https://orcid.org/0000-0001-6894-4110"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Buse","raw_affiliation_strings":["University of North Carolina School of Medicine Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina School of Medicine Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084623347","display_name":"Giorgio Sesti","orcid":"https://orcid.org/0000-0002-1618-7688","observed_orcids":["https://orcid.org/0000-0002-1618-7688"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Sesti","raw_affiliation_strings":["Universita degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy,","Universita degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy,","institution_ids":["https://openalex.org/I36443711"]},{"raw_affiliation_string":"Universita degli Studi Magna Gr\u00e6cia di Catanzaro, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084593004","display_name":"Melanie Jane Davies","orcid":"https://orcid.org/0000-0002-9987-9371","observed_orcids":["https://orcid.org/0000-0002-9987-9371"]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melanie J. Davies","raw_affiliation_strings":["Leicester Royal Infirmary Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leicester Royal Infirmary Leicester, United Kingdom","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061856428","display_name":"Klaus H. Jensen","orcid":"https://orcid.org/0000-0003-3234-6068","observed_orcids":["https://orcid.org/0000-0003-3234-6068"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Klaus H. Jensen","raw_affiliation_strings":["Novo Nordisk A/S, Soborg, Denmark,","Novo Nordisk A/S , S\u00f8borg , Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Soborg, Denmark,","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S , S\u00f8borg , Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111550916","display_name":"Jason Brett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268700","display_name":"Novo Nordisk Canada (Canada)","ror":"https://ror.org/01th56526","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405268700"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jason Brett","raw_affiliation_strings":["Novo Nordisk, Inc., Princeton, New, Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk, Inc., Princeton, New, Jersey","institution_ids":["https://openalex.org/I4405268700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[{"id":"https://openalex.org/I4405270336","display_name":"AdventHealth","ror":"https://ror.org/00gqase94","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405270336"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Pratley","raw_affiliation_strings":["Diabetes Institute, Florida Hospital, Orlando, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Institute, Florida Hospital, Orlando, Florida","institution_ids":["https://openalex.org/I4405270336"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5045462483"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"],"apc_list":{"value":3480,"currency":"USD","value_usd":3480},"apc_paid":null,"fwci":0.3306,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.30245747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"6","first_page":"906","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9350000023841858},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":0.7689999938011169},{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":0.8989999890327454},{"id":"https://openalex.org/keywords/sitagliptin","display_name":"sitagliptin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.8920000195503235},{"id":"https://openalex.org/keywords/exenatide","display_name":"exenatide","score":1.0},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8500000238418579},{"id":"https://openalex.org/keywords/antihyperglycemic-therapy","display_name":"antihyperglycemic therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/glycemic-targets","display_name":"glycemic targets","score":0.8479999899864197},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9438915252685547},{"id":"https://openalex.org/C2776307423","wikidata":"https://www.wikidata.org/wiki/Q425027","display_name":"Glimepiride","level":4,"score":0.922609806060791},{"id":"https://openalex.org/C2781308992","wikidata":"https://www.wikidata.org/wiki/Q2526479","display_name":"Liraglutide","level":4,"score":0.8854891061782837},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.6803877353668213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5818802118301392},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.577575147151947},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.5754361152648926},{"id":"https://openalex.org/C2780533449","wikidata":"https://www.wikidata.org/wiki/Q417762","display_name":"Exenatide","level":4,"score":0.5234605669975281},{"id":"https://openalex.org/C2779284873","wikidata":"https://www.wikidata.org/wiki/Q419832","display_name":"Sitagliptin","level":4,"score":0.5136787295341492},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4693860709667206},{"id":"https://openalex.org/C2777538456","wikidata":"https://www.wikidata.org/wiki/Q311213","display_name":"Glycated hemoglobin","level":4,"score":0.4604398012161255},{"id":"https://openalex.org/C2777393523","wikidata":"https://www.wikidata.org/wiki/Q50008082","display_name":"Hemoglobin A","level":3,"score":0.4410865604877472},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.32314831018447876},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3056056797504425},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19352635741233826}],"mesh":[{"descriptor_ui":"D000067757","descriptor_name":"Glucagon-Like Peptide-1 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069450","descriptor_name":"Liraglutide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018027","descriptor_name":"Receptors, Glucagon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4158/ep.17.6.906","doi":"https://doi.org/10.4158/ep.17.6.906","is_oa":false,"landing_page_url":"https://doi.org/10.4158/ep.17.6.906","pdf_url":null,"source":{"id":"https://openalex.org/S165390330","display_name":"Endocrine Practice","issn_l":"1530-891X","issn":["1530-891X","1934-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Practice","raw_type":"journal-article"},{"id":"pmid:22193143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22193143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists","raw_type":"Comparative Study"},{"id":"pmh:oai:iris.uniroma1.it:11573/1312573","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1312573","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W354890834","https://openalex.org/W1983133005","https://openalex.org/W2012117258","https://openalex.org/W2015893101","https://openalex.org/W2028272916","https://openalex.org/W2042129134","https://openalex.org/W2050826565","https://openalex.org/W2061549173","https://openalex.org/W2071770035","https://openalex.org/W2071835038","https://openalex.org/W2098459806","https://openalex.org/W2113367996","https://openalex.org/W2137352234","https://openalex.org/W2138290933","https://openalex.org/W2155568871","https://openalex.org/W2159347383","https://openalex.org/W2160001758","https://openalex.org/W2170606300","https://openalex.org/W2610940923"],"related_works":["https://openalex.org/W2133162614","https://openalex.org/W7037660426","https://openalex.org/W2050851282","https://openalex.org/W2948324842","https://openalex.org/W2944529529","https://openalex.org/W2809206610","https://openalex.org/W2067650081","https://openalex.org/W2331252176","https://openalex.org/W2083415436","https://openalex.org/W2325199747"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}