{"id":"https://openalex.org/W2022851768","doi":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","title":"DIFFERENTIAL EFFECTS OF TWO AMPHETAMINE\u2010BARBITURATE MIXTURES IN MAN","display_name":"DIFFERENTIAL EFFECTS OF TWO AMPHETAMINE\u2010BARBITURATE MIXTURES IN MAN","publication_year":1965,"publication_date":"1965-02-01","ids":{"openalex":"https://openalex.org/W2022851768","doi":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","mag":"2022851768","pmid":"https://pubmed.ncbi.nlm.nih.gov/14301994","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1704062"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1965.tb02076.x","doi":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1965.tb02076.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1965.tb02076.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084458562","display_name":"David W. Dickins","orcid":"https://orcid.org/0000-0003-2030-5541","observed_orcids":["https://orcid.org/0000-0003-2030-5541"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. W. DICKINS","raw_affiliation_strings":["Department of Pharmacology, University College London","Psychology Department, University of Liverpool"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Psychology Department, University of Liverpool","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108285762","display_name":"MALCOLM H. LADER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115181","display_name":"Maudsley Hospital","ror":"https://ror.org/02788t795","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923","https://openalex.org/I4210115181"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. H. LADER","raw_affiliation_strings":["Department of Pharmacology, University College London","Institute of Psychiatry, Maudsley Hospital, Denmark Hill, London, S.E.5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Psychiatry, Maudsley Hospital, Denmark Hill, London, S.E.5","institution_ids":["https://openalex.org/I4210115181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052338854","display_name":"Hannah Steinberg","orcid":"https://orcid.org/0000-0002-0271-0191","observed_orcids":["https://orcid.org/0000-0002-0271-0191"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"HANNAH STEINBERG","raw_affiliation_strings":["Department of Pharmacology, University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2331,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.73402675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":"14","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-amphetamine","display_name":"d-amphetamine","score":0.6480000019073486},{"id":"https://openalex.org/keywords/amylobarbitone","display_name":"amylobarbitone","score":0.9670000076293945},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3790000081062317},{"id":"https://openalex.org/keywords/elation","display_name":"elation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pulse-rate","display_name":"pulse rate","score":0.4909999966621399},{"id":"https://openalex.org/keywords/psychomotor-function","display_name":"psychomotor performance","score":0.6309999823570251},{"id":"https://openalex.org/keywords/central-nervous-system-effects","display_name":"central nervous system effects","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2780077838","wikidata":"https://www.wikidata.org/wiki/Q206348","display_name":"Barbiturate","level":2,"score":0.4492824375629425},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.44724220037460327},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4469425678253174},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43335655331611633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4038221538066864},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.261052668094635},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17199262976646423}],"mesh":[{"descriptor_ui":"D000661","descriptor_name":"Amphetamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000662","descriptor_name":"Amphetamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001463","descriptor_name":"Barbiturates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008606","descriptor_name":"Mental Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009048","descriptor_name":"Motor Skills","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1965.tb02076.x","doi":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1965.tb02076.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1704062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1704062","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol Chemother","raw_type":"Text"},{"id":"pmid:14301994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14301994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1965.tb02076.x","doi":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1965.tb02076.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1965.tb02076.x","source":{"id":"https://openalex.org/S2755662391","display_name":"British Journal of Pharmacology and Chemotherapy","issn_l":"0366-0826","issn":["0366-0826","2056-8177"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022851768.pdf","grobid_xml":"https://content.openalex.org/works/W2022851768.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W382594183","https://openalex.org/W1975305679","https://openalex.org/W1993406222","https://openalex.org/W2002664886","https://openalex.org/W2004572815","https://openalex.org/W2013254925","https://openalex.org/W2018365549","https://openalex.org/W2018466104","https://openalex.org/W2022973383","https://openalex.org/W2027590856","https://openalex.org/W2031304160","https://openalex.org/W2035831984","https://openalex.org/W2037642248","https://openalex.org/W2041282815","https://openalex.org/W2047294057","https://openalex.org/W2053293311","https://openalex.org/W2064781783","https://openalex.org/W2080515558","https://openalex.org/W2104699974","https://openalex.org/W2133560314","https://openalex.org/W2408138728","https://openalex.org/W2794663839","https://openalex.org/W4231145374","https://openalex.org/W4290970049"],"related_works":["https://openalex.org/W2018365549","https://openalex.org/W2051670294","https://openalex.org/W2075873900","https://openalex.org/W2004572815","https://openalex.org/W2010072666","https://openalex.org/W1993406222","https://openalex.org/W1967197440","https://openalex.org/W1998972541","https://openalex.org/W2417054597","https://openalex.org/W4245346381"],"abstract_inverted_index":{"Mixtures":[0],"of":[1,19,42,59,62,68,92,102,105,155,190,237,266,298,308,313,340,343,354,372,393],"amphetamine":[2,63,128,224,355],"and":[3,22,65,70,81,130,158,184,226,258,289,356,374,383],"a":[4,50,57,89,120,170,188,205,255,331,349],"barbiturate":[5,113,168,357],"continue":[6],"to":[7,195,243,245,263,275],"be":[8,196,244,388],"fairly":[9,378],"widely":[10,171,379],"used":[11,161,172,380],"in":[12,16,77,122,153,187,212,249,253,285,295,301,310,361,381],"psy-":[13],"chiatry,":[14],"especially":[15,252],"the":[17,40,71,86,95,100,103,112,123,193,198,209,214,230,233,267,270,290,296,303,317,321,344,351,364,366,385,391,394],"treatment":[18],"mild":[20],"anxiety":[21],"depression":[23],"(Lancet,":[24],"1962;":[25,29],"British":[26],"Medical":[27],"Journal,":[28],"Ornstein":[30],"&":[31,54,178],"Whitman,":[32],"1963),":[33],"but":[34],"relatively":[35],"little":[36],"is":[37],"known":[38],"about":[39],"effects":[41,93,312,353,386],"such":[43],"mixtures":[44,241,342],"from":[45,94,139],"laboratory":[46],"experiments":[47,194,291],"on":[48,316],"man.In":[49],"previous":[51],"investigation":[52],"(Legge":[53],"Steinberg,":[55],"1962)":[56],"mixture":[58,87,160,200,206],"15":[60],"mg":[61,67],"sulphate":[64,183,225],"300":[66],"cyclobarbitone":[69,227],"two":[72,210,341],"ingredients":[73],"separately":[74],"were":[75,228,273,281,292,359,368,377,397],"studied":[76,398],"normal":[78],"human":[79],"subjects,":[80],"it":[82,98,115,131,323],"was":[83,149,201,261,324],"found":[84],"that":[85,220,326,370,384],"produced":[88,116,132],"different":[90],"pattern":[91],"separate":[96],"ingredients:":[97],"impaired":[99],"efficiency":[101],"performance":[104],"three":[106],"simple":[107,306],"tasks":[108],"less":[109],"than":[110,142],"did":[111,127,143],"alone;":[114,129],"almost":[117],"as":[118,126,166,169,217,348],"big":[119],"rise":[121],"pulse":[124],"rate":[125],"spontaneous":[133],"reports":[134,154,265],"suggesting":[135],"\"":[136,138],"elation":[137],"more":[140],"subjects":[141,280,367],"either":[144,334],"drug":[145,240],"separately,":[146],"though":[147],"there":[148],"no":[150],"corresponding":[151],"increase":[152],"other":[156],"feelings":[157],"sensations.The":[159],"contained":[162,208],"proportionally":[163],"several":[164],"times":[165],"much":[167],"commercial":[173],"preparation,":[174],"Drinamyl":[175],"(Smith,":[176],"Kline":[177],"French),":[179],"which":[180,207,302],"contains":[181],"dexamphetamine":[182],"amylobarbitone":[185],"sodium":[186],"ratio":[189],"1:":[191],"6.5.In":[192],"reported":[197],"earlier":[199],"therefore":[202],"compared":[203],"with":[204],"drugs":[211,314,358,376],"approximately":[213],"same":[215],"proportions":[216],"Drinamyl,":[218],"except":[219],"for":[221],"practical":[222,299],"reasons":[223],"again":[229],"compounds":[231],"used.Since":[232],"main":[234,352],"clinical":[235],"aim":[236],"using":[238],"these":[239],"appears":[242],"induce":[246],"favourable":[247],"changes":[248],"subjective":[250],"reactions,":[251],"moods,":[254],"standard-":[256],"ized":[257],"detailed":[259],"method":[260],"adopted":[262],"elicit":[264],"subjects'":[268],"feelings.Otherwise":[269],"test":[271],"methods":[272],"similar":[274],"those":[276],"previously":[277],"used.":[278],"METHODSThe":[279],"preclinical":[282],"medical":[283],"students":[284,304],"their":[286],"fourth":[287],"term,":[288],"carried":[293],"out":[294],"course":[297],"classes":[300],"learned":[305],"ways":[307],"assessing":[309],"man":[311],"acting":[315],"central":[318],"nervous":[319],"system.Before":[320],"experiment":[322],"explained":[325],"each":[327],"student":[328],"would":[329,387],"receive":[330],"tablet":[332],"containing":[333],"amphetamine,":[335],"or":[336,338,346],"cyclobarbitone,":[337],"one":[339],"two,":[345],"lactose":[347],"control;":[350],"described":[360],"general":[362],"terms.Regarding":[363],"mixtures,":[365],"told":[369],"combinations":[371],"depressant":[373],"stimulant":[375],"medicine,":[382],"discussed":[389],"at":[390],"end":[392],"class.The":[395],"following":[396]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}