{"id":"https://openalex.org/W2022845130","doi":"https://doi.org/10.1046/j.1365-2362.1999.00463.x","title":"Chlamydia pneumoniae reactive T lymphocytes in the walls of abdominal aortic aneurysms","display_name":"Chlamydia pneumoniae reactive T lymphocytes in the walls of abdominal aortic aneurysms","publication_year":1999,"publication_date":"1999-06-01","ids":{"openalex":"https://openalex.org/W2022845130","doi":"https://doi.org/10.1046/j.1365-2362.1999.00463.x","mag":"2022845130","pmid":"https://pubmed.ncbi.nlm.nih.gov/10354217"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2362.1999.00463.x","doi":"https://doi.org/10.1046/j.1365-2362.1999.00463.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2362.1999.00463.x","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000487895","display_name":"S. Halme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"S. Halme","raw_affiliation_strings":["National Public Health Institute, Oulu, University of Oulu, Finland","National Public Health Institute, Oulu,","University of Oulu, Oulu,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Public Health Institute, Oulu, University of Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"National Public Health Institute, Oulu,","institution_ids":[]},{"raw_affiliation_string":"University of Oulu, Oulu,","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109134539","display_name":"Tatu Sakari Juvonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"T. Juvonen","raw_affiliation_strings":["Oulu University Hospital, Oulu,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Oulu,","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108536176","display_name":"Aino Laurila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Laurila","raw_affiliation_strings":["National Public Health Institute, Oulu,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Public Health Institute, Oulu,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751667","display_name":"Jukka Juvonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148628","display_name":"Kainuun keskussairaala","ror":"https://ror.org/040yv4379","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210148628"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"J. Juvonen","raw_affiliation_strings":["Central Hospital of Kainuu, Kajaani, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Hospital of Kainuu, Kajaani, Finland","institution_ids":["https://openalex.org/I4210148628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108999190","display_name":"Matti-Aleksi Mosorin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. Mosorin","raw_affiliation_strings":["Oulu University Hospital, Oulu,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Oulu,","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075015536","display_name":"Pekka Saikku","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Saikku","raw_affiliation_strings":["National Public Health Institute, Oulu,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Public Health Institute, Oulu,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111496361","display_name":"Helj\u00e4\u2010Marja Surcel","orcid":"https://orcid.org/0000-0002-5770-1380","observed_orcids":["https://orcid.org/0000-0002-5770-1380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.\u2010M. Surcel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109134539","https://openalex.org/A5111751667"],"corresponding_institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I4210148628"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":6.0672,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.96191253,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"29","issue":"6","first_page":"546","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12453","display_name":"Infectious Aortic and Vascular Conditions","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydia-pneumoniae","display_name":"Chlamydia pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antigen-specific-t-cell-proliferation","display_name":"antigen-specific T cell proliferation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/aortitis","display_name":"aortitis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cd45ro-t-cells","display_name":"CD45RO+ memory T cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5189999938011169},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7160000205039978},{"id":"https://openalex.org/keywords/t-cell-lines","display_name":"T cell lines","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7550020217895508},{"id":"https://openalex.org/C2778419347","wikidata":"https://www.wikidata.org/wiki/Q132319","display_name":"Chlamydophila pneumoniae","level":4,"score":0.6421765089035034},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5051663517951965},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4961737096309662},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4633064866065979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42127883434295654},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.41163623332977295},{"id":"https://openalex.org/C2780122209","wikidata":"https://www.wikidata.org/wiki/Q153356","display_name":"Chlamydia","level":2,"score":0.39061611890792847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.363044410943985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3499932289123535},{"id":"https://openalex.org/C2777038808","wikidata":"https://www.wikidata.org/wiki/Q13474598","display_name":"Chlamydiaceae","level":3,"score":0.18663430213928223}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016993","descriptor_name":"Chlamydophila pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016993","descriptor_name":"Chlamydophila pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017544","descriptor_name":"Aortic Aneurysm, Abdominal","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2362.1999.00463.x","doi":"https://doi.org/10.1046/j.1365-2362.1999.00463.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2362.1999.00463.x","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:10354217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10354217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W126987811","https://openalex.org/W1543657232","https://openalex.org/W1558221257","https://openalex.org/W1587697394","https://openalex.org/W1598614064","https://openalex.org/W1666569441","https://openalex.org/W1981343643","https://openalex.org/W1984781373","https://openalex.org/W1991609451","https://openalex.org/W1999833937","https://openalex.org/W2002368631","https://openalex.org/W2015652416","https://openalex.org/W2017524691","https://openalex.org/W2020853125","https://openalex.org/W2027181290","https://openalex.org/W2038628039","https://openalex.org/W2049057533","https://openalex.org/W2053906855","https://openalex.org/W2061041332","https://openalex.org/W2071808530","https://openalex.org/W2076749881","https://openalex.org/W2077228061","https://openalex.org/W2089166710","https://openalex.org/W2102907425","https://openalex.org/W2105044959","https://openalex.org/W2118403859","https://openalex.org/W2154596400","https://openalex.org/W2154696423","https://openalex.org/W2155036039","https://openalex.org/W2155807420","https://openalex.org/W2160722686","https://openalex.org/W2163233433","https://openalex.org/W2339946950","https://openalex.org/W4249899366","https://openalex.org/W4253973486"],"related_works":["https://openalex.org/W2155807420","https://openalex.org/W2416439611","https://openalex.org/W1976900227","https://openalex.org/W172900548","https://openalex.org/W2150974492","https://openalex.org/W2088863129","https://openalex.org/W2016783457","https://openalex.org/W2396159871","https://openalex.org/W1969147368","https://openalex.org/W1972171854"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,146,205],"presence":[2,117,134,173,206],"of":[3,9,26,50,81,108,118,129,135,142,150,174,183,200,207,231,246],"Chlamydia":[4,187],"pneumoniae":[5,45,137,188,209,226],"in":[6,21,55,115,139,171,180,198,214,228,235,243],"the":[7,22,34,40,47,82,88,99,109,116,133,143,151,164,172,184,201,219,229,232,236,244,247],"walls":[8],"abdominal":[10],"aortic":[11,27],"aneurysms":[12],"(AAAs)":[13],"has":[14],"been":[15],"demonstrated":[16],"recently,":[17],"but":[18],"its":[19],"role":[20],"cause":[23],"and/or":[24],"maintenance":[25,230],"wall":[28],"inflammation":[29,54],"is":[30],"not":[31],"known.":[32],"In":[33,91],"present":[35],"study,":[36],"we":[37],"have":[38],"investigated":[39],"possible":[41],"relationship":[42],"between":[43],"C.":[44,136,208,225],"and":[46,105,158,238],"antigen":[48,106,138,170,189],"specificity":[49,107],"T":[51,94,156,211],"lymphocytes":[52,95,212],"mediating":[53],"AAA":[56,68,130,152,220],"tissue.":[57],"MATERIALS":[58],"AND":[59],"METHODS:":[60],"Tissue":[61],"specimens":[62,100,166,222],"were":[63,96,167],"obtained":[64],"from":[65,98,218],"22":[66,185],"consecutive":[67],"patients":[69],"undergoing":[70],"elective":[71],"surgery":[72],"(mean":[73],"age":[74],"67":[75],"+/-":[76],"1":[77],"year).":[78],"Immunohistochemical":[79],"analysis":[80],"formalin-fixed":[83],"tissue":[84,131,153,165,221,237],"was":[85,113,178,190],"performed":[86],"using":[87,122],"streptavidin-biotin-peroxidase":[89],"method.":[90],"vivo":[92,215],"activated":[93,216],"propagated":[97],"with":[101],"interleukin":[102],"(IL)":[103],"2,":[104],"established":[110],"T-cell":[111],"lines":[112],"analysed":[114],"autologous":[119],"antigen-presenting":[120],"cells":[121,217],"radioactive":[123],"thymidine":[124],"labelling.":[125],"RESULTS:":[126],"Immunohistological":[127],"staining":[128],"showed":[132],"55%":[140],"(6/11)":[141],"samples":[144],"studied.":[145],"inflammatory":[147,233],"cell":[148],"infiltrate":[149],"contained":[154],"60-90%":[155],"(CD45RO)":[157],"0-10%":[159],"B":[160],"(CD20)":[161],"cells.":[162],"When":[163],"cultured":[168],"without":[169],"IL-2,":[175],"lymphocyte":[176],"propagation":[177],"achieved":[179],"17":[181,202],"out":[182],"samples.":[186],"found":[191],"to":[192],"induce":[193],"a":[194],"positive":[195],"proliferative":[196],"response":[197,234],"8":[199],"lines.":[203],"CONCLUSIONS:":[204],"specific":[210],"among":[213],"suggests":[223],"that":[224],"participates":[227],"may":[239],"thus":[240],"be":[241],"involved":[242],"progression":[245],"disease.":[248]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}