{"id":"https://openalex.org/W2022840703","doi":"https://doi.org/10.1002/jcp.10308","title":"Hyperoxia induces Egr\u20101 expression through activation of extracellular signal\u2010regulated kinase 1/2 pathway","display_name":"Hyperoxia induces Egr\u20101 expression through activation of extracellular signal\u2010regulated kinase 1/2 pathway","publication_year":2003,"publication_date":"2003-06-10","ids":{"openalex":"https://openalex.org/W2022840703","doi":"https://doi.org/10.1002/jcp.10308","mag":"2022840703","pmid":"https://pubmed.ncbi.nlm.nih.gov/12811826"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.10308","doi":"https://doi.org/10.1002/jcp.10308","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.10308","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nicole Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Jones","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052746065","display_name":"Faton H. Agani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Faton H. Agani","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052746065"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":1.7917,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.83912306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"196","issue":"2","first_page":"326","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.461899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/egr1","display_name":"EGR1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pi-3-kinase","display_name":"PI3-kinase","score":0.902999997138977},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5820000171661377},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.9092790484428406},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8102995157241821},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6651217341423035},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6579881906509399},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6265701055526733},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.524898886680603},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5014569759368896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4927413761615753},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.49180176854133606},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4388488531112671},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.4326724112033844},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.3213098347187042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16171813011169434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12517884373664856},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.1098741888999939}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.10308","doi":"https://doi.org/10.1002/jcp.10308","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.10308","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:12811826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12811826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6015516375","display_name":"Mitochondria and regulation of HIF-1","funder_award_id":"R01NS041309","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8434403640","display_name":"MECHANISMS OF APOPTOTIC DEATH IN DOPAMINERGIC NEURONS","funder_award_id":"R01NS039469","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320322755","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W42031309","https://openalex.org/W1521510973","https://openalex.org/W1566540765","https://openalex.org/W1567881416","https://openalex.org/W1705232837","https://openalex.org/W1963981548","https://openalex.org/W1964304127","https://openalex.org/W1968830328","https://openalex.org/W1980669305","https://openalex.org/W1980692339","https://openalex.org/W1982023759","https://openalex.org/W1984767179","https://openalex.org/W1992938326","https://openalex.org/W2001230322","https://openalex.org/W2001381510","https://openalex.org/W2003142397","https://openalex.org/W2005065484","https://openalex.org/W2006345574","https://openalex.org/W2014945678","https://openalex.org/W2017597379","https://openalex.org/W2023189063","https://openalex.org/W2026301617","https://openalex.org/W2031578545","https://openalex.org/W2041456547","https://openalex.org/W2048983596","https://openalex.org/W2049370164","https://openalex.org/W2050912993","https://openalex.org/W2051241476","https://openalex.org/W2052537645","https://openalex.org/W2059028043","https://openalex.org/W2069637592","https://openalex.org/W2071366179","https://openalex.org/W2087367550","https://openalex.org/W2090280626","https://openalex.org/W2092368761","https://openalex.org/W2111986039","https://openalex.org/W2118959467","https://openalex.org/W2120787511","https://openalex.org/W2123995229","https://openalex.org/W2145084438","https://openalex.org/W2148700883","https://openalex.org/W2149719174","https://openalex.org/W2151920252","https://openalex.org/W2156396769","https://openalex.org/W2256253694"],"related_works":["https://openalex.org/W69449422","https://openalex.org/W1968259548","https://openalex.org/W2074990934","https://openalex.org/W2065882173","https://openalex.org/W2372222353","https://openalex.org/W4296491896","https://openalex.org/W2031988022","https://openalex.org/W2129480791","https://openalex.org/W2142079271","https://openalex.org/W3158590511"],"abstract_inverted_index":{"Early":[0],"growth":[1,17,120],"response":[2,8,70,165,202],"gene":[3,9],"(Egr-1)":[4],"is":[5,126],"a":[6,80,160,183],"stress":[7,15],"activated":[10],"by":[11,108],"various":[12],"forms":[13,182],"of":[14,25,49,67,83,99,140,187],"and":[16,31,61,134,172,195],"factor":[18,121],"signaling.":[19,124],"We":[20],"report":[21],"that":[22,152,166],"supraphysiologic":[23],"concentrations":[24],"O(2)":[26,155],"(hyperoxia)":[27],"induced":[28],"Egr-1":[29,68,106,114,179,191],"mRNA":[30],"protein":[32,52],"expression":[33],"in":[34,42,45,69,79,87,131,137,145],"cultured":[35],"alveolar":[36,89],"epithelial":[37,90],"cells,":[38],"as":[39,41,128],"well":[40],"mouse":[43,88],"lung":[44,147],"vivo.":[46],"The":[47,110],"contribution":[48],"the":[50,65,150,163],"mitogen-activated":[51],"kinase":[53,54,57],"(MEK)/extracellular":[55],"signal-regulated":[56],"(ERK),":[58],"p38":[59,100],"MAPK":[60,101],"PI3-kinase":[62,103],"pathways":[63],"to":[64,71,76,118,178,203],"activation":[66,115,192],"hyperoxia":[72,77,164,194],"was":[73,116],"examined.":[74],"Exposure":[75],"resulted":[78],"rapid":[81],"phosphorylation":[82],"ERK":[84],"1/2":[85],"kinases":[86],"cells":[91],"LA4.":[92],"MEK":[93],"inhibitor":[94],"PD98059,":[95],"but":[96],"not":[97],"inhibitors":[98],"or":[102],"pathway,":[104,171],"prevented":[105],"induction":[107],"hyperoxia.":[109],"signaling":[111,175],"cascade":[112],"preceding":[113],"traced":[117],"epidermal":[119],"receptor":[122],"(EGFR)":[123],"Hyperoxia":[125],"used":[127],"supplemental":[129],"therapy":[130],"some":[132],"diseases":[133],"typically":[135],"results":[136,158],"elevated":[138],"levels":[139],"reactive":[141],"oxygen":[142,204],"intermediates":[143],"(ROI)":[144],"many":[146],"cell":[148,201],"types,":[149],"organ":[151],"receives":[153],"highest":[154],"exposure.":[156],"Our":[157],"support":[159],"pathway":[161],"for":[162,185,199],"involves":[167],"EGF":[168],"receptor,":[169],"MEK/ERK":[170],"other":[173],"unknown":[174],"components":[176],"leading":[177],"induction.":[180],"This":[181],"foundation":[184],"analysis":[186],"detailed":[188],"mechanisms":[189],"underlying":[190],"during":[193],"understanding":[196],"its":[197],"consequences":[198],"regulating":[200],"toxicity.":[205]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}