{"id":"https://openalex.org/W2022820520","doi":"https://doi.org/10.1186/gb-2010-11-5-208","title":"The next frontier of systems biology: higher-order and interspecies interactions","display_name":"The next frontier of systems biology: higher-order and interspecies interactions","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2022820520","doi":"https://doi.org/10.1186/gb-2010-11-5-208","mag":"2022820520","pmid":"https://pubmed.ncbi.nlm.nih.gov/20441613","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898071"},"language":"en","primary_location":{"id":"doi:10.1186/gb-2010-11-5-208","doi":"https://doi.org/10.1186/gb-2010-11-5-208","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2010-11-5-208","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2010-11-5-208","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2010-11-5-208","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050241478","display_name":"Michael Andrew Fischbach","orcid":"https://orcid.org/0000-0003-3079-8247","observed_orcids":["https://orcid.org/0000-0003-3079-8247","https://orcid.org/0000-0002-9203-4026"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A Fischbach","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences and California Institute of Quantitative Biosciences, University of California, San Francisco, CA 94158, USA. fischbach@fischbachgroup.org","Department of Bioengineering and Therapeutic Sciences and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences and California Institute of Quantitative Biosciences, University of California, San Francisco, CA 94158, USA. fischbach@fischbachgroup.org","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026080576","display_name":"Nevan J. Krogan","orcid":"https://orcid.org/0000-0003-4902-337X","observed_orcids":["https://orcid.org/0000-0003-4902-337X"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nevan J Krogan","raw_affiliation_strings":["Department of Cellular and Molecular Pharmacology and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, 94158, USA","Department of Cellular and Molecular Pharmacology and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, 94158, USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Cellular and Molecular Pharmacology and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026080576","https://openalex.org/A5050241478"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I180670191"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":1.0765,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73132604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"5","first_page":"208","last_page":"208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy of Biology and Scientific Explanation","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.9679999947547913},{"id":"https://openalex.org/keywords/higher-order-interactions","display_name":"higher-order interactions","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interspecies-interactions","display_name":"interspecies interactions","score":0.996999979019165},{"id":"https://openalex.org/keywords/network-biology","display_name":"network biology","score":0.4259999990463257},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.4740000069141388},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.527999997138977},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.685670793056488},{"id":"https://openalex.org/C2778571376","wikidata":"https://www.wikidata.org/wiki/Q1355821","display_name":"Frontier","level":2,"score":0.663747251033783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5678397417068481},{"id":"https://openalex.org/C182306322","wikidata":"https://www.wikidata.org/wiki/Q1779371","display_name":"Order (exchange)","level":2,"score":0.5542126893997192},{"id":"https://openalex.org/C36415437","wikidata":"https://www.wikidata.org/wiki/Q7663871","display_name":"Systems medicine","level":3,"score":0.43330058455467224},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4229791760444641},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3876287639141083},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.08695262670516968},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.08414945006370544},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/gb-2010-11-5-208","doi":"https://doi.org/10.1186/gb-2010-11-5-208","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2010-11-5-208","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2010-11-5-208","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2098367","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898071","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2898071","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2898071","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:20441613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20441613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2n25c3xn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2n25c3xn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome biology, vol 11, iss 5","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2n25c3xn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2n25c3xn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, vol 11, iss 5","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/gb-2010-11-5-208","doi":"https://doi.org/10.1186/gb-2010-11-5-208","is_oa":true,"landing_page_url":"https://doi.org/10.1186/gb-2010-11-5-208","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2010-11-5-208","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022820520.pdf","grobid_xml":"https://content.openalex.org/works/W2022820520.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W131810194","https://openalex.org/W147290053","https://openalex.org/W1533712488","https://openalex.org/W1569060300","https://openalex.org/W1644749979","https://openalex.org/W1968698890","https://openalex.org/W1970250905","https://openalex.org/W1990786456","https://openalex.org/W2010577059","https://openalex.org/W2013158844","https://openalex.org/W2016593548","https://openalex.org/W2018756605","https://openalex.org/W2032664706","https://openalex.org/W2034016149","https://openalex.org/W2034775855","https://openalex.org/W2042045767","https://openalex.org/W2044398806","https://openalex.org/W2050721857","https://openalex.org/W2068702161","https://openalex.org/W2068880841","https://openalex.org/W2076710572","https://openalex.org/W2076962060","https://openalex.org/W2082314789","https://openalex.org/W2091015733","https://openalex.org/W2100380298","https://openalex.org/W2111967267","https://openalex.org/W2116117181","https://openalex.org/W2123634400","https://openalex.org/W2127073167","https://openalex.org/W2128036243","https://openalex.org/W2139119391","https://openalex.org/W2140948740","https://openalex.org/W2142437744","https://openalex.org/W2145848202","https://openalex.org/W2146264532"],"related_works":["https://openalex.org/W2208618022","https://openalex.org/W1996392179","https://openalex.org/W2122264917","https://openalex.org/W250626939","https://openalex.org/W2606564142","https://openalex.org/W2184674864","https://openalex.org/W3183067306","https://openalex.org/W7100578085","https://openalex.org/W7096328261","https://openalex.org/W172889218"],"abstract_inverted_index":{"Systems":[0],"approaches":[1],"are":[2],"not":[3],"so":[4,21],"different":[5],"in":[6,15],"essence":[7],"from":[8],"classical":[9],"genetic":[10],"and":[11,14],"biochemical":[12],"approaches,":[13],"the":[16,24],"future":[17],"may":[18],"become":[19,30],"adopted":[20],"widely":[22],"that":[23],"term":[25],"'systems":[26],"biology'":[27],"itself":[28],"will":[29],"obsolete.":[31]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
