{"id":"https://openalex.org/W2022818656","doi":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","title":"Structural and mechanistic insights into Mps1 kinase activation","display_name":"Structural and mechanistic insights into Mps1 kinase activation","publication_year":2008,"publication_date":"2008-12-16","ids":{"openalex":"https://openalex.org/W2022818656","doi":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","mag":"2022818656","pmid":"https://pubmed.ncbi.nlm.nih.gov/19120698","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2829362"},"language":"en","primary_location":{"id":"doi:10.1111/j.1582-4934.2008.00605.x","doi":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2008.00605.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2008.00605.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003831859","display_name":"Yuting Yang","orcid":"https://orcid.org/0000-0003-2077-2780","observed_orcids":["https://orcid.org/0000-0003-2077-2780"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuting Yang","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA","These authors contributed equally"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"These authors contributed equally","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102995878","display_name":"Yuefeng Gao","orcid":"https://orcid.org/0000-0001-5788-1804","observed_orcids":["https://orcid.org/0000-0001-5788-1804"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuefeng Gao","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053792216","display_name":"Quanbin Xu","orcid":"https://orcid.org/0000-0002-2833-9773","observed_orcids":["https://orcid.org/0000-0002-2833-9773"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quanbin Xu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431441","display_name":"Feng Wang","orcid":"https://orcid.org/0000-0001-7235-1676","observed_orcids":["https://orcid.org/0000-0001-7235-1676","https://orcid.org/0009-0007-5238-8704","https://orcid.org/0000-0002-3826-5579"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Wang","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640883","display_name":"Songcheng Zhu","orcid":"https://orcid.org/0000-0003-3943-3543","observed_orcids":["https://orcid.org/0000-0003-3943-3543"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Songcheng Zhu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049717541","display_name":"William M. Old","orcid":"https://orcid.org/0000-0002-9499-8478","observed_orcids":["https://orcid.org/0000-0002-9499-8478"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Old","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108339789","display_name":"Katheryn A. Resing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katheryn Resing","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066949514","display_name":"Natalie G. Ahn","orcid":"https://orcid.org/0000-0002-2690-2630","observed_orcids":["https://orcid.org/0000-0002-2690-2630"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Ahn","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","Howard Hughes Medical Institute, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069405087","display_name":"Ming Lei","orcid":"https://orcid.org/0000-0002-1153-4791","observed_orcids":["https://orcid.org/0000-0002-1153-4791"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming Lei","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080793835","display_name":"Xuedong Liu","orcid":"https://orcid.org/0000-0001-7209-4964","observed_orcids":["https://orcid.org/0000-0001-7209-4964"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xuedong Liu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069405087","https://openalex.org/A5080793835"],"corresponding_institution_ids":["https://openalex.org/I188538660","https://openalex.org/I27837315"],"apc_list":{"value":5210,"currency":"USD","value_usd":5210},"apc_paid":null,"fwci":0.8952,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.68034541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"8b","first_page":"1679","last_page":"1694"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mps1-kinase","display_name":"Mps1 kinase","score":1.0},{"id":"https://openalex.org/keywords/mitotic-spindle-assembly-checkpoint","display_name":"mitotic spindle checkpoint","score":0.8550000190734863},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/kinase-domain-crystal-structure","display_name":"kinase domain crystal structure","score":0.8539999723434448},{"id":"https://openalex.org/keywords/inactive-conformation","display_name":"inactive conformation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"autophosphorylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/activation-loop","display_name":"activation loop","score":0.7730000019073486},{"id":"https://openalex.org/keywords/transphosphorylation","display_name":"transphosphorylation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/substrate-recruitment","display_name":"substrate recruitment","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/spindle-damage","display_name":"spindle damage","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.9416666030883789},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.5969568490982056},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5952290296554565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4844236671924591},{"id":"https://openalex.org/C59143045","wikidata":"https://www.wikidata.org/wiki/Q15314942","display_name":"Cyclin-dependent kinase 9","level":5,"score":0.4614831805229187},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44337233901023865},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4263022541999817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4078254997730255},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.40446174144744873},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3787079155445099},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.36872220039367676},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.13553735613822937},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1582-4934.2008.00605.x","doi":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2008.00605.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1909429","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2829362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19120698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19120698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2829362","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2829362/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/74441","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/74441","pdf_url":"https://hdl.handle.net/2027.42/74441","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/j.1582-4934.2008.00605.x","doi":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1582-4934.2008.00605.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1582-4934.2008.00605.x","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G102163711","display_name":null,"funder_award_id":"DE\u2010 AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1286251239","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G1384768361","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G2219523378","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G222407312","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2287611682","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G2363639003","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G262962599","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3152346458","display_name":null,"funder_award_id":"DE-AC02-06CH11357","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3244038948","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G3351052168","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G402281873","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G426311843","display_name":null,"funder_award_id":"DE-AC- 02-06CH11357","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G4385809619","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4866076653","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G536846052","display_name":"Mechanisms of p27Kipl Proteolysis in Cancer Cells","funder_award_id":"R01CA107098","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5387317844","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G5607048534","display_name":null,"funder_award_id":"DE-AC02\u201306CH11357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6004781752","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6848031779","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6918803902","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G7583137537","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G7688398576","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G993149817","display_name":null,"funder_award_id":"DE-AC02-06CH11357 ","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022818656.pdf","grobid_xml":"https://content.openalex.org/works/W2022818656.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W93901503","https://openalex.org/W192751579","https://openalex.org/W1539796472","https://openalex.org/W1591680814","https://openalex.org/W1880615100","https://openalex.org/W1963750681","https://openalex.org/W1973916918","https://openalex.org/W1981433220","https://openalex.org/W1983544779","https://openalex.org/W1984428716","https://openalex.org/W1991116680","https://openalex.org/W1992945955","https://openalex.org/W1995017064","https://openalex.org/W1995627045","https://openalex.org/W2012347372","https://openalex.org/W2013083986","https://openalex.org/W2025216788","https://openalex.org/W2036827835","https://openalex.org/W2037023154","https://openalex.org/W2061946629","https://openalex.org/W2063330798","https://openalex.org/W2067234514","https://openalex.org/W2067405360","https://openalex.org/W2072945335","https://openalex.org/W2077278757","https://openalex.org/W2082723977","https://openalex.org/W2089001126","https://openalex.org/W2092961902","https://openalex.org/W2106285650","https://openalex.org/W2114460232","https://openalex.org/W2118460316","https://openalex.org/W2127926172","https://openalex.org/W2134435289","https://openalex.org/W2137984821","https://openalex.org/W2140224974","https://openalex.org/W2142227713","https://openalex.org/W2144827830","https://openalex.org/W2145009672","https://openalex.org/W2146958715","https://openalex.org/W2154809041","https://openalex.org/W2157471438","https://openalex.org/W2161340336","https://openalex.org/W2161698983","https://openalex.org/W2171641076","https://openalex.org/W2172240299"],"related_works":["https://openalex.org/W2037023154","https://openalex.org/W2144827830","https://openalex.org/W2905981291","https://openalex.org/W2112299240","https://openalex.org/W2790606657","https://openalex.org/W2124092111","https://openalex.org/W422442234","https://openalex.org/W7143476491","https://openalex.org/W2973032422","https://openalex.org/W2912835894"],"abstract_inverted_index":{"Mps1":[0,21,42,62,112,202],"is":[1,10,22,135],"one":[2],"of":[3,20,49,53,81,142,156,192],"the":[4,38,46,50,61,73,78,82,86,90,94,97,116,119,131,138,175],"several":[5],"essential":[6,184],"kinases":[7],"whose":[8],"activation":[9,117,123],"required":[11],"for":[12,107,163,185,201],"robust":[13],"mitotic":[14],"spindle":[15,34],"checkpoint":[16],"signalling.":[17],"The":[18,55],"activity":[19],"tightly":[23],"regulated":[24],"and":[25,85,118,149,180,188],"increases":[26],"dramatically":[27],"during":[28],"mitosis":[29],"or":[30],"in":[31,77,89,96,115,174],"response":[32],"to":[33,102],"damage.":[35],"To":[36],"understand":[37],"molecular":[39],"mechanism":[40],"underlying":[41],"regulation,":[43],"we":[44,152,168],"determined":[45],"crystal":[47,57],"structure":[48,58],"kinase":[51,63,95,108,127,193,203],"domain":[52,64],"Mps1.":[54],"2.7-A-resolution":[56],"shows":[59],"that":[60,154,182],"adopts":[65],"a":[66,104,160],"unique":[67],"inactive":[68,98],"conformation.":[69,99],"Intramolecular":[70],"interactions":[71],"between":[72,177],"key":[74],"Glu":[75],"residue":[76],"C":[79],"helix":[80],"N-terminal":[83],"lobe":[84],"backbone":[87],"amides":[88],"catalytic":[91],"loop":[92,124,133,176],"lock":[93],"Autophosphorylation":[100],"appears":[101],"be":[103,159],"priming":[105,161],"event":[106,162],"activation.":[109],"We":[110],"identified":[111,169],"autophosphorylation":[113,125,129,144,148],"sites":[114],"P+1":[120,132],"loops.":[121],"Whereas":[122],"enhances":[126],"activity,":[128],"at":[130,165],"(T686)":[134],"associated":[136],"with":[137],"active":[139],"kinase.":[140],"Mutation":[141],"T686":[143],"site":[145],"impairs":[146],"both":[147],"transphosphorylation.":[150],"Furthermore,":[151],"demonstrated":[153],"phosphorylation":[155,164],"T676":[157],"may":[158],"T686.":[166],"Finally,":[167],"two":[170],"critical":[171,198],"lysine":[172],"residues":[173],"helices":[178],"EF":[179],"F":[181],"are":[183],"substrate":[186],"recruitment":[187],"maintaining":[189],"high":[190],"levels":[191],"activity.":[194],"Our":[195],"studies":[196],"reveal":[197],"biochemical":[199],"mechanisms":[200],"regulation.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}