{"id":"https://openalex.org/W2022790697","doi":"https://doi.org/10.1073/pnas.0810562105","title":"Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis","display_name":"Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis","publication_year":2008,"publication_date":"2008-12-03","ids":{"openalex":"https://openalex.org/W2022790697","doi":"https://doi.org/10.1073/pnas.0810562105","mag":"2022790697","pmid":"https://pubmed.ncbi.nlm.nih.gov/19052238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2604977"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0810562105","doi":"https://doi.org/10.1073/pnas.0810562105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0810562105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2604977","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stanislav Sokolov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Sokolov","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195-7280","Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002307585","display_name":"Todd Scheuer","orcid":"https://orcid.org/0000-0003-3655-0816","observed_orcids":["https://orcid.org/0000-0003-3655-0816"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Scheuer","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195-7280"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078941732","display_name":"William A. Catterall","orcid":"https://orcid.org/0000-0001-5509-3580","observed_orcids":["https://orcid.org/0000-0001-5509-3580"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Catterall","raw_affiliation_strings":["Department of Pharmacology, University of Washington, Seattle, WA 98195-7280"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":1.8995,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.84809789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"105","issue":"50","first_page":"19980","last_page":"19985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nav1-4-sodium-channel","display_name":"Nav1.4 sodium channel","score":0.8180000185966492},{"id":"https://openalex.org/keywords/slow-inactivation","display_name":"slow inactivation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.4000000059604645},{"id":"https://openalex.org/keywords/sodium-influx","display_name":"sodium influx","score":0.6290000081062317},{"id":"https://openalex.org/keywords/contractile-failure","display_name":"contractile failure","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.9017964601516724},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.8589301109313965},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.6830031275749207},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6705467700958252},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.6342520117759705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6142905354499817},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.5012633800506592},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4853028655052185},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.451009601354599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24552887678146362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1641560196876526},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010245","descriptor_name":"Paralyses, Familial Periodic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010245","descriptor_name":"Paralyses, Familial Periodic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062687","descriptor_name":"Sodium Channel Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0810562105","doi":"https://doi.org/10.1073/pnas.0810562105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0810562105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2604977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2604977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:19052238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19052238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2604977","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2604977","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6737517775","display_name":"Voltage Sensitive Sodium Channels in Brain","funder_award_id":"R01NS015751","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W107588712","https://openalex.org/W1576505582","https://openalex.org/W1937176890","https://openalex.org/W1969129798","https://openalex.org/W1975202593","https://openalex.org/W1983187084","https://openalex.org/W1983519301","https://openalex.org/W1985146688","https://openalex.org/W1985543740","https://openalex.org/W1987382493","https://openalex.org/W1988669735","https://openalex.org/W1998484925","https://openalex.org/W1999108741","https://openalex.org/W2018981526","https://openalex.org/W2054750757","https://openalex.org/W2057460931","https://openalex.org/W2059084665","https://openalex.org/W2073315960","https://openalex.org/W2076113078","https://openalex.org/W2078700589","https://openalex.org/W2081912246","https://openalex.org/W2085980752","https://openalex.org/W2094677101","https://openalex.org/W2095332486","https://openalex.org/W2098499866","https://openalex.org/W2100995549","https://openalex.org/W2104689137","https://openalex.org/W2106670341","https://openalex.org/W2111389201","https://openalex.org/W2120771179","https://openalex.org/W2127627247","https://openalex.org/W2134353614","https://openalex.org/W2136291641","https://openalex.org/W2139670802","https://openalex.org/W2139852988","https://openalex.org/W2143125286","https://openalex.org/W2144178449","https://openalex.org/W2160142455","https://openalex.org/W2165095603","https://openalex.org/W2170154282","https://openalex.org/W2317041692"],"related_works":["https://openalex.org/W1999896739","https://openalex.org/W2078589887","https://openalex.org/W2105806128","https://openalex.org/W1998078867","https://openalex.org/W2803105126","https://openalex.org/W2081912246","https://openalex.org/W2031974620","https://openalex.org/W1987134183","https://openalex.org/W3043304383","https://openalex.org/W1975202593"],"abstract_inverted_index":{"Some":[0],"inherited":[1],"periodic":[2,28,83],"paralyses":[3],"are":[4],"caused":[5,87],"by":[6,88,119],"mutations":[7,30,89,107],"in":[8,39,44,57,90,95,108,125,144,195],"skeletal":[9],"muscle":[10,185],"Na(V)1.4":[11,49,100,110],"sodium":[12,61,71,171],"channels":[13,167],"that":[14,68,105,116,137],"alter":[15],"channel":[16],"gating":[17,37,53,93,113,139],"and":[18,73,121,148,178,187,192],"impair":[19],"action":[20,182],"potential":[21,177],"generation.":[22],"In":[23,133],"the":[24,34,40,48,65,91,99,126,130,145,160,174],"case":[25],"of":[26,31,33,47,60,98,129,164,181],"hypokalemic":[27],"paralysis,":[29],"one":[32],"outermost":[35],"two":[36],"charges":[38],"S4":[41],"voltage":[42,66,131,162],"sensor":[43,67,163],"domain":[45,96],"II":[46,97],"alpha":[50],"subunit":[51],"induce":[52],"pore":[54,114,140,157],"current,":[55],"resulting":[56],"a":[58],"leak":[59],"or":[62],"protons":[63],"through":[64,159],"causes":[69],"depolarization,":[70],"overload,":[72],"contractile":[74,190],"failure":[75,191],"correlated":[76],"with":[77],"low":[78],"serum":[79],"potassium.":[80],"Potassium-sensitive":[81],"normokalemic":[82],"paralysis":[84],"(NormoPP)":[85],"is":[86,117,123,142,149],"third":[92],"charge":[94],"channel.":[101],"Here,":[102],"we":[103,135],"report":[104],"these":[106],"rat":[109],"(R669Q/G/W)":[111],"cause":[112,169],"current":[115,141,158],"activated":[118,127],"depolarization":[120],"therefore":[122],"conducted":[124],"state":[128,147],"sensor.":[132],"addition,":[134],"find":[136],"this":[138],"retained":[143],"slow-inactivated":[146,165],"deactivated":[150],"only":[151],"at":[152,173],"hyperpolarized":[153],"membrane":[154,176],"potentials.":[155],"Gating":[156],"mutant":[161],"NormoPP":[166],"would":[168],"increased":[170],"influx":[172],"resting":[175],"during":[179],"trains":[180],"potentials,":[183],"depolarize":[184],"fibers,":[186],"lead":[188],"to":[189],"cellular":[193],"pathology":[194],"NormoPP.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
