{"id":"https://openalex.org/W2022779304","doi":"https://doi.org/10.1016/s0014-4827(03)00309-4","title":"Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts","display_name":"Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts","publication_year":2003,"publication_date":"2003-08-12","ids":{"openalex":"https://openalex.org/W2022779304","doi":"https://doi.org/10.1016/s0014-4827(03)00309-4","mag":"2022779304","pmid":"https://pubmed.ncbi.nlm.nih.gov/14567979"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-4827(03)00309-4","doi":"https://doi.org/10.1016/s0014-4827(03)00309-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-4827(03)00309-4","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009966599","display_name":"Claudio A. Torres","orcid":"https://orcid.org/0000-0002-7103-5783","observed_orcids":["https://orcid.org/0000-0002-7103-5783"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio Torres","raw_affiliation_strings":["The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113649309","display_name":"Mary Kay Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Kay Francis","raw_affiliation_strings":["The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005124809","display_name":"Antonello Lorenzini","orcid":"https://orcid.org/0000-0001-9615-9697","observed_orcids":["https://orcid.org/0000-0001-9615-9697"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonello Lorenzini","raw_affiliation_strings":["The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012506113","display_name":"Maria Tresini","orcid":"https://orcid.org/0000-0001-7711-3204","observed_orcids":["https://orcid.org/0000-0001-7711-3204"]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Tresini","raw_affiliation_strings":["The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055763114","display_name":"Vincent J. Cristofalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182321934","display_name":"Lankenau Institute for Medical Research","ror":"https://ror.org/030g3hg75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I182321934"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent J Cristofalo","raw_affiliation_strings":["The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA","institution_ids":["https://openalex.org/I182321934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055763114"],"corresponding_institution_ids":["https://openalex.org/I182321934"],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":null,"fwci":1.32,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.77285462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"290","issue":"2","first_page":"195","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.33079999685287476,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mkp-2","display_name":"MKP-2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.9010000228881836},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/wi-38-fibroblasts","display_name":"WI-38 fibroblasts","score":0.8980000019073486},{"id":"https://openalex.org/keywords/proteasome-activity","display_name":"proteasome activity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8086485862731934},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.7195728421211243},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7190831899642944},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6845942139625549},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6093893051147461},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.537956714630127},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5300680994987488},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5034043192863464},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.43164339661598206},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.427062064409256},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.4213809072971344},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.416336327791214},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.41360875964164734},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4132188558578491},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.32482558488845825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.323782742023468},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.20410925149917603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17429190874099731}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007976","descriptor_name":"Leupeptins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054637","descriptor_name":"Dual-Specificity Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054639","descriptor_name":"Mitogen-Activated Protein Kinase Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054648","descriptor_name":"Protein Phosphatase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0014-4827(03)00309-4","doi":"https://doi.org/10.1016/s0014-4827(03)00309-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-4827(03)00309-4","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:14567979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14567979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Comparative Study"},{"id":"pmh:oai:cris.unibo.it:11585/955193","doi":null,"is_oa":false,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/S0014482703003094?via=ihub","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2123151222","display_name":null,"funder_award_id":"AG00378","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2808087123","display_name":null,"funder_award_id":"AG00378","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G308169915","display_name":"Regulation of the MAP Kinase Pathway in Senescence","funder_award_id":"R01AG020955","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3700451641","display_name":null,"funder_award_id":"AG20955","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W131581480","https://openalex.org/W161994666","https://openalex.org/W190261825","https://openalex.org/W287842095","https://openalex.org/W1791271593","https://openalex.org/W1966550850","https://openalex.org/W1969294711","https://openalex.org/W1970810825","https://openalex.org/W1973963032","https://openalex.org/W1977575725","https://openalex.org/W1984206772","https://openalex.org/W1984972991","https://openalex.org/W1992093304","https://openalex.org/W1993353592","https://openalex.org/W1999853328","https://openalex.org/W2002282120","https://openalex.org/W2007555056","https://openalex.org/W2020184457","https://openalex.org/W2021021216","https://openalex.org/W2023664482","https://openalex.org/W2028526611","https://openalex.org/W2034681915","https://openalex.org/W2034883634","https://openalex.org/W2042921323","https://openalex.org/W2048781554","https://openalex.org/W2050252881","https://openalex.org/W2051899951","https://openalex.org/W2052071148","https://openalex.org/W2060588008","https://openalex.org/W2062397310","https://openalex.org/W2064129448","https://openalex.org/W2073106992","https://openalex.org/W2073922677","https://openalex.org/W2079350783","https://openalex.org/W2080352303","https://openalex.org/W2080453174","https://openalex.org/W2080918528","https://openalex.org/W2082632084","https://openalex.org/W2085797277","https://openalex.org/W2100847793","https://openalex.org/W2105989455","https://openalex.org/W2111305451","https://openalex.org/W2112251100","https://openalex.org/W2115701574","https://openalex.org/W2117245487","https://openalex.org/W2119670701","https://openalex.org/W2129498342","https://openalex.org/W2134812217","https://openalex.org/W2140490890","https://openalex.org/W2145592505","https://openalex.org/W2145906341","https://openalex.org/W2159831275","https://openalex.org/W2164010163","https://openalex.org/W2288844445","https://openalex.org/W2299926476","https://openalex.org/W4211258630","https://openalex.org/W6610356322"],"related_works":["https://openalex.org/W2054644399","https://openalex.org/W1983846798","https://openalex.org/W2090741482","https://openalex.org/W1976324142","https://openalex.org/W2157151526","https://openalex.org/W2061227901","https://openalex.org/W2002733731","https://openalex.org/W7026029947","https://openalex.org/W1991721995","https://openalex.org/W2043092024"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
