{"id":"https://openalex.org/W2022700331","doi":"https://doi.org/10.1007/bf00370302","title":"Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre","display_name":"Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2022700331","doi":"https://doi.org/10.1007/bf00370302","mag":"2022700331","pmid":"https://pubmed.ncbi.nlm.nih.gov/1664937"},"language":"en","primary_location":{"id":"doi:10.1007/bf00370302","doi":"https://doi.org/10.1007/bf00370302","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00370302","pdf_url":null,"source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\ufffdgers Archiv European Journal of Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2022700331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060607593","display_name":"\u00c9velyne Benoit","orcid":"https://orcid.org/0000-0001-5501-0888","observed_orcids":["https://orcid.org/0000-0001-5501-0888"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Evelyne Benoit","raw_affiliation_strings":["Laboratoire de Physiologie compar\u00e9e, URA CNRS 1121, Universit\u00e9 Paris Sud, Orsay, France","Laboratoire de Physiologie Compar\u00e9e, URA CNRS 1121, b\u00e2t. 443, Universit\u00e9 Paris-Sud, Orsay Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiologie compar\u00e9e, URA CNRS 1121, Universit\u00e9 Paris Sud, Orsay, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Laboratoire de Physiologie Compar\u00e9e, URA CNRS 1121, b\u00e2t. 443, Universit\u00e9 Paris-Sud, Orsay Cedex, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103423891","display_name":"Denis Escande","orcid":"https://orcid.org/0000-0002-0460-8385","observed_orcids":["https://orcid.org/0000-0002-0460-8385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denis Escande","raw_affiliation_strings":["Rh\u00f4ne-Poulenc Rorer, Centre de Recherches de Vitry, 13 Quai J. Guesde, F-94403, Vitry-sur-Seine, France","Rh\u00f4ne-Poulenc Rorer, Centre de Recherches de Vitry, Vitry-sur-Seine, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rh\u00f4ne-Poulenc Rorer, Centre de Recherches de Vitry, 13 Quai J. Guesde, F-94403, Vitry-sur-Seine, France","institution_ids":[]},{"raw_affiliation_string":"Rh\u00f4ne-Poulenc Rorer, Centre de Recherches de Vitry, Vitry-sur-Seine, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.0025,"has_fulltext":false,"cited_by_count":223,"citation_normalized_percentile":{"value":0.86995089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"419","issue":"6","first_page":"603","last_page":"609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riluzole","display_name":"riluzole","score":1.0},{"id":"https://openalex.org/keywords/sodium-channel-blockade","display_name":"sodium channel blockade","score":0.7059999704360962},{"id":"https://openalex.org/keywords/nodes-of-ranvier","display_name":"nodes of Ranvier","score":0.875},{"id":"https://openalex.org/keywords/myelinated-nerve-fibers","display_name":"myelinated axons","score":0.9580000042915344},{"id":"https://openalex.org/keywords/potassium-currents","display_name":"potassium currents","score":0.5379999876022339},{"id":"https://openalex.org/keywords/use-dependent-block","display_name":"use-dependent block","score":0.6200000047683716},{"id":"https://openalex.org/keywords/steady-state-inactivation","display_name":"steady-state inactivation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/recovery-from-inactivation","display_name":"recovery from inactivation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.8169999718666077},{"id":"https://openalex.org/keywords/frog-sciatic-nerve","display_name":"frog sciatic nerve","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2779319286","wikidata":"https://www.wikidata.org/wiki/Q415744","display_name":"Riluzole","level":4,"score":0.9064176082611084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4287446141242981},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.11700144410133362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06469675898551941},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05528107285499573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011893","descriptor_name":"Rana esculenta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011901","descriptor_name":"Ranvier's Nodes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011901","descriptor_name":"Ranvier's Nodes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019782","descriptor_name":"Riluzole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00370302","doi":"https://doi.org/10.1007/bf00370302","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00370302","pdf_url":null,"source":{"id":"https://openalex.org/S203465302","display_name":"Pfl\u00fcgers Archiv - European Journal of Physiology","issn_l":"0031-6768","issn":["0031-6768","0365-267X","1432-2013"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pfl\ufffdgers Archiv European Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:1664937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1664937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pflugers Archiv : European journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W160004286","https://openalex.org/W1965878712","https://openalex.org/W1977347051","https://openalex.org/W1979546613","https://openalex.org/W1991404498","https://openalex.org/W2012698812","https://openalex.org/W2015220091","https://openalex.org/W2025712791","https://openalex.org/W2044802282","https://openalex.org/W2069884282","https://openalex.org/W2116411564","https://openalex.org/W2143239901","https://openalex.org/W2245220155","https://openalex.org/W2333030118","https://openalex.org/W2334565321","https://openalex.org/W2398056820","https://openalex.org/W3179996438"],"related_works":["https://openalex.org/W1924751878","https://openalex.org/W2025765372","https://openalex.org/W1966742463","https://openalex.org/W2105741259","https://openalex.org/W2775804686","https://openalex.org/W1983568884","https://openalex.org/W1994904086","https://openalex.org/W3136167647","https://openalex.org/W1979456296"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}