{"id":"https://openalex.org/W2022676367","doi":"https://doi.org/10.1016/j.ymthe.2006.08.371","title":"315. Identification and Control of Bacterial Contamination in an Academic Good Manufacturing Practice Facility","display_name":"315. Identification and Control of Bacterial Contamination in an Academic Good Manufacturing Practice Facility","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2022676367","doi":"https://doi.org/10.1016/j.ymthe.2006.08.371","mag":"2022676367"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2006.08.371","doi":"https://doi.org/10.1016/j.ymthe.2006.08.371","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.371","pdf_url":"http://www.cell.com/article/S1525001606006289/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cell.com/article/S1525001606006289/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040675375","display_name":"Timothy P. O\u2019Connor","orcid":"https://orcid.org/0000-0002-2512-9973","observed_orcids":["https://orcid.org/0000-0002-2512-9973"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy P. O'Connor","raw_affiliation_strings":["Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001983513","display_name":"Neil R. Hackett","orcid":"https://orcid.org/0009-0006-9184-4437","observed_orcids":["https://orcid.org/0009-0006-9184-4437"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil R. Hackett","raw_affiliation_strings":["Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111782009","display_name":"Robert G. Pergolizzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Pergolizzi","raw_affiliation_strings":["Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075726671","display_name":"Dolan Sondhi","orcid":"https://orcid.org/0000-0002-2218-5910","observed_orcids":["https://orcid.org/0000-0002-2218-5910"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolan Sondhi","raw_affiliation_strings":["Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038176504","display_name":"Julie L. Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie L. Boyer","raw_affiliation_strings":["Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023263749","display_name":"Stephen M. Kaminsky","orcid":"https://orcid.org/0000-0003-1869-834X","observed_orcids":["https://orcid.org/0000-0003-1869-834X"]},"institutions":[{"id":"https://openalex.org/I1310987316","display_name":"International AIDS Vaccine Initiative","ror":"https://ror.org/05ayv2203","country_code":"US","type":"funder","lineage":["https://openalex.org/I1310987316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M. Kaminsky","raw_affiliation_strings":["International AIDS Vaccine Initiative, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International AIDS Vaccine Initiative, New York, NY","institution_ids":["https://openalex.org/I1310987316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064433832","display_name":"Ronald G. Crystal","orcid":"https://orcid.org/0000-0001-6177-6839","observed_orcids":["https://orcid.org/0000-0001-6177-6839"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald G. Crystal","raw_affiliation_strings":["Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12771211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"S120","last_page":"S120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.3700999915599823,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.3700999915599823,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11002","display_name":"Indoor Air Quality and Microbial Exposure","score":0.18440000712871552,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-contamination","display_name":"bacterial contamination","score":0.9819999933242798},{"id":"https://openalex.org/keywords/good-manufacturing-practices","display_name":"good manufacturing practices","score":0.6340000033378601},{"id":"https://openalex.org/keywords/gene-therapy-manufacturing","display_name":"gene therapy manufacturing","score":0.6230000257492065},{"id":"https://openalex.org/keywords/contamination-monitoring","display_name":"contamination monitoring","score":0.5360000133514404},{"id":"https://openalex.org/keywords/biosafety-cabinet","display_name":"biological safety cabinet","score":0.699999988079071},{"id":"https://openalex.org/keywords/particle-monitoring","display_name":"particle monitoring","score":0.37700000405311584},{"id":"https://openalex.org/keywords/contamination-control","display_name":"contamination control","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C112570922","wikidata":"https://www.wikidata.org/wiki/Q60528603","display_name":"Contamination","level":2,"score":0.7412176728248596},{"id":"https://openalex.org/C93497512","wikidata":"https://www.wikidata.org/wiki/Q5164919","display_name":"Contamination control","level":3,"score":0.5174849033355713},{"id":"https://openalex.org/C2779709869","wikidata":"https://www.wikidata.org/wiki/Q1292017","display_name":"Good manufacturing practice","level":3,"score":0.5113093852996826},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.46295908093452454},{"id":"https://openalex.org/C2778660310","wikidata":"https://www.wikidata.org/wiki/Q177998","display_name":"Agar","level":3,"score":0.4178640842437744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4164457321166992},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.37224912643432617},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3483244776725769},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2780511413","wikidata":"https://www.wikidata.org/wiki/Q18749628","display_name":"Regulatory affairs","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ymthe.2006.08.371","doi":"https://doi.org/10.1016/j.ymthe.2006.08.371","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.371","pdf_url":"http://www.cell.com/article/S1525001606006289/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2006.08.371","doi":"https://doi.org/10.1016/j.ymthe.2006.08.371","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2006.08.371","pdf_url":"http://www.cell.com/article/S1525001606006289/pdf","source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2022676367.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142218311","https://openalex.org/W4245483731","https://openalex.org/W2945841426","https://openalex.org/W1975351647","https://openalex.org/W2176669291","https://openalex.org/W4251843418","https://openalex.org/W4240603762","https://openalex.org/W125241394","https://openalex.org/W2484429608","https://openalex.org/W4399592551"],"abstract_inverted_index":{"An":[0],"ongoing":[1],"monitoring":[2,59],"program":[3,60],"is":[4,70],"an":[5],"essential":[6],"component":[7],"of":[8,19,47],"operating":[9],"a":[10,33],"Good":[11],"Manufacturing":[12],"Practice":[13],"(GMP)":[14],"facility.":[15],"To":[16],"support":[17],"manufacture":[18],"clinical":[20],"grade":[21],"viral":[22],"gene":[23],"transfer":[24],"vectors,":[25],"the":[26],"Belfer":[27],"Gene":[28],"Therapy":[29],"Core":[30],"Facility":[31],"has":[32],"Class":[34,52],"100,000":[35],"GMP":[36],"facility":[37],"with":[38],"three":[39],"production":[40,48],"laboratories,":[41],"in":[42,51],"which":[43],"all":[44],"open":[45],"operations":[46],"are":[49],"conducted":[50],"100":[53],"biological":[54],"safety":[55],"cabinets.":[56],"The":[57],"routine":[58],"measures":[61],"viable":[62],"and":[63,67],"non-viable":[64],"particles":[65],"weekly":[66],"temporal":[68],"trending":[69],"assessed":[71],"to":[72],"identify":[73],"emerging":[74],"problems.":[75]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
