{"id":"https://openalex.org/W2022644576","doi":"https://doi.org/10.1016/j.stem.2010.03.009","title":"The Hair Follicle Bulge Stem Cell Niche Resists Transformation by the Hedgehog Pathway","display_name":"The Hair Follicle Bulge Stem Cell Niche Resists Transformation by the Hedgehog Pathway","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2022644576","doi":"https://doi.org/10.1016/j.stem.2010.03.009","mag":"2022644576","pmid":"https://pubmed.ncbi.nlm.nih.gov/20362530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3689650"},"language":"en","primary_location":{"id":"doi:10.1016/j.stem.2010.03.009","doi":"https://doi.org/10.1016/j.stem.2010.03.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2010.03.009","pdf_url":"http://www.cell.com/article/S1934590910001062/pdf","source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1934590910001062/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085814203","display_name":"Todd W. Ridky","orcid":"https://orcid.org/0000-0001-8482-1284","observed_orcids":["https://orcid.org/0000-0001-8482-1284"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd W. Ridky","raw_affiliation_strings":["Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010090782","display_name":"Paul A. Khavari","orcid":"https://orcid.org/0000-0003-0098-4989","observed_orcids":["https://orcid.org/0000-0003-0098-4989"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul A. Khavari","raw_affiliation_strings":["Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: khavari@stanford.edu","Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA; Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: khavari@stanford.edu","institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Veterans Affairs, Palo Alto Healthcare System, Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010090782"],"corresponding_institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":0.6509,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.65406945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":"4","first_page":"292","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tumor-origin","display_name":"tumor origin","score":0.753000020980835},{"id":"https://openalex.org/keywords/interfollicular-epidermis","display_name":"interfollicular epidermis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.798844575881958},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.7459004521369934},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5519440174102783},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5471129417419434},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5280283689498901},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.525047779083252},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.5104193091392517},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.47337669134140015},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.41080614924430847},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29154273867607117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20403599739074707},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19330346584320068},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16645127534866333},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.13149330019950867},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12509089708328247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.stem.2010.03.009","doi":"https://doi.org/10.1016/j.stem.2010.03.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2010.03.009","pdf_url":"http://www.cell.com/article/S1934590910001062/pdf","source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},{"id":"pmid:20362530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20362530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell stem cell","raw_type":"Comment"},{"id":"pmh:oai:europepmc.org:2683821","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3689650","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3689650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3689650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Stem Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.stem.2010.03.009","doi":"https://doi.org/10.1016/j.stem.2010.03.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.stem.2010.03.009","pdf_url":"http://www.cell.com/article/S1934590910001062/pdf","source":{"id":"https://openalex.org/S128124174","display_name":"Cell stem cell","issn_l":"1875-9777","issn":["1875-9777","1934-5909"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Stem Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6078157621","display_name":"Regulators of Tumorigenesis","funder_award_id":"R01CA142635","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000859491","display_name":"Epidermal Signaling Regulators","funder_award_id":"R01AR049737","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2022644576.pdf"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1594815607","https://openalex.org/W1980332250","https://openalex.org/W2005341482","https://openalex.org/W2021354108","https://openalex.org/W2035524441","https://openalex.org/W2070110701","https://openalex.org/W2093358903","https://openalex.org/W2140619393"],"related_works":["https://openalex.org/W1986404157","https://openalex.org/W2069857832","https://openalex.org/W1970960957","https://openalex.org/W1998092199","https://openalex.org/W2157069235","https://openalex.org/W2338325982","https://openalex.org/W2935788226","https://openalex.org/W2093358903","https://openalex.org/W1978670524","https://openalex.org/W2019667717"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}