{"id":"https://openalex.org/W2022632526","doi":"https://doi.org/10.1055/s-1997-1234","title":"Expeditious Syntheses of Two Arylglycine Derivatives Corresponding to the Central Amino Acid of the Vancomycin Family of Antibiotics","display_name":"Expeditious Syntheses of Two Arylglycine Derivatives Corresponding to the Central Amino Acid of the Vancomycin Family of Antibiotics","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2022632526","doi":"https://doi.org/10.1055/s-1997-1234","mag":"2022632526"},"language":"en","primary_location":{"id":"doi:10.1055/s-1997-1234","doi":"https://doi.org/10.1055/s-1997-1234","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-1997-1234","pdf_url":null,"source":{"id":"https://openalex.org/S197964166","display_name":"Synthesis","issn_l":"0039-7881","issn":["0039-7881","1437-210X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072747947","display_name":"Anthony J. Pearson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J. Pearson","raw_affiliation_strings":["Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006; E-mail [email\u00a0protected]","Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006","E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006; E-mail [email\u00a0protected]","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"E-mail","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113622543","display_name":"Mariappan V. Chelliah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariappan V. Chelliah","raw_affiliation_strings":["Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006; E-mail [email\u00a0protected]","Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006","E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006; E-mail [email\u00a0protected]","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"E-mail","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Gilles C. Bignan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilles C. Bignan","raw_affiliation_strings":["Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006; E-mail [email\u00a0protected]","Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006","E-mail"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006; E-mail [email\u00a0protected]","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA, Fax +1(216)3683006","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"E-mail","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":1.5448,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78445168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1997","issue":"05","first_page":"536","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.29249998927116394,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.29249998927116394,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.21979999542236328,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.2184000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.75},{"id":"https://openalex.org/keywords/ristocetin","display_name":"ristocetin","score":0.902999997138977},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9475622177124023},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7161566019058228},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.6720097661018372},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6512402892112732},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.6085352301597595},{"id":"https://openalex.org/C2776057759","wikidata":"https://www.wikidata.org/wiki/Q904599","display_name":"Ristocetin","level":4,"score":0.5271515250205994},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5141480565071106},{"id":"https://openalex.org/C2779390152","wikidata":"https://www.wikidata.org/wiki/Q2293474","display_name":"Glycopeptide antibiotic","level":5,"score":0.5073713660240173},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.49490422010421753},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.47107329964637756},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4154942035675049},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3532482385635376},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.11554399132728577},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10240247845649719},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0444415807723999},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-1997-1234","doi":"https://doi.org/10.1055/s-1997-1234","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-1997-1234","pdf_url":null,"source":{"id":"https://openalex.org/S197964166","display_name":"Synthesis","issn_l":"0039-7881","issn":["0039-7881","1437-210X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthesis","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2951371615","https://openalex.org/W2951512797","https://openalex.org/W2104629787","https://openalex.org/W2008452479","https://openalex.org/W2061737286","https://openalex.org/W2067571731","https://openalex.org/W2036930023","https://openalex.org/W2135397988","https://openalex.org/W2153729327","https://openalex.org/W2074774295"],"abstract_inverted_index":{"All":[0],"articles":[1],"of":[2,24,40,57,94,98],"this":[3],"category":[4],"Two":[5],"expeditious":[6],"and":[7,12,77,84,100],"efficient":[8,55],"syntheses":[9,73],"(in":[10],"7":[11],"4":[13],"steps,":[14],"respectively)":[15],"are":[16,74,85],"described":[17],"for":[18],"the":[19,25,51,92,95],"central":[20],"amino":[21,111],"acid":[22,112],"part":[23],"vancomycin":[26,99,102],"family.":[27],"The":[28],"first":[29],"method":[30],"constitutes":[31],"a":[32,58],"concise":[33],"asymmetric":[34,47,108],"synthesis,":[35],"starting":[36,64],"from":[37,65],"4-hydroxyphenylacetic":[38],"acid,":[39],"(":[41,68],"R":[42,69],")-(3,5-dihydroxy-4-methoxyphenyl)glycine":[43],"derivatives":[44],"using":[45],"Evans\u2019":[46],"azidation":[48],"methodology.":[49],"In":[50],"second":[52],"approach,":[53],"an":[54,89],"synthesis":[56,109],"protected":[59],"3,5-dichloro-4-methoxyphenylglycine":[60],"derivative":[61],"is":[62],"described,":[63,83],"commercially":[66],"available":[67],")-4-hydroxyphenylglycine.":[70],"These":[71],"two":[72],"much":[75],"shorter":[76],"operationally":[78],"simpler":[79],"than":[80],"those":[81],"previously":[82],"currently":[86],"employed":[87],"in":[88],"effort":[90],"towards":[91],"construction":[93],"bicyclic":[96],"system":[97],"ristocetin.":[101],"-":[103,105,107,110],"antibiotic":[104],"arylglycine":[106]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
