{"id":"https://openalex.org/W2022628868","doi":"https://doi.org/10.1038/nrn1034","title":"The role of histamine and the tuberomamillary nucleus in the nervous system","display_name":"The role of histamine and the tuberomamillary nucleus in the nervous system","publication_year":2003,"publication_date":"2003-01-31","ids":{"openalex":"https://openalex.org/W2022628868","doi":"https://doi.org/10.1038/nrn1034","mag":"2022628868","pmid":"https://pubmed.ncbi.nlm.nih.gov/12563283"},"language":"en","primary_location":{"id":"doi:10.1038/nrn1034","doi":"https://doi.org/10.1038/nrn1034","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn1034","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110429983","display_name":"Helmut L. Haas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut Haas","raw_affiliation_strings":["Department of Neurophysiology, Heinrich-Heine University, Dusseldorf, Germany. haas@uni-duesseldorf.de","Department of Neurophysiology, Heinrich Heine University, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, Heinrich-Heine University, Dusseldorf, Germany. haas@uni-duesseldorf.de","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Department of Neurophysiology, Heinrich Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014800650","display_name":"Pertti Panula","orcid":"https://orcid.org/0000-0002-1189-5132","observed_orcids":["https://orcid.org/0000-0002-1189-5132"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pertti Panula","raw_affiliation_strings":["Department of Biology, Abo Akademi University and Institute of Biomedicine, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Abo Akademi University and Institute of Biomedicine, University of Helsinki, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3157,"has_fulltext":false,"cited_by_count":929,"citation_normalized_percentile":{"value":0.99380165,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"2","first_page":"121","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.37549999356269836,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.37549999356269836,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.2506999969482422,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.20679999887943268,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histaminergic-system","display_name":"histaminergic system","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tuberomamillary-nucleus","display_name":"tuberomamillary nucleus","score":0.902999997138977},{"id":"https://openalex.org/keywords/histamine-receptors","display_name":"histamine receptors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sleep-wake-cycle","display_name":"sleep-wake cycle","score":0.9120000004768372},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/endocrine-homeostasis","display_name":"endocrine homeostasis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.996999979019165},{"id":"https://openalex.org/keywords/learning","display_name":"learning","score":0.9309999942779541}],"concepts":[{"id":"https://openalex.org/C2778501154","wikidata":"https://www.wikidata.org/wiki/Q18349602","display_name":"Histaminergic","level":3,"score":0.9811612367630005},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7480267286300659},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6357274055480957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5829139947891235},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5766593217849731},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.5555383563041687},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4958134591579437},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.45081597566604614},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.44277533888816833},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38500043749809265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19811809062957764},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1933266818523407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06617170572280884}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001519","descriptor_name":"Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009424","descriptor_name":"Nervous System Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011968","descriptor_name":"Receptors, Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrn1034","doi":"https://doi.org/10.1038/nrn1034","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn1034","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:12563283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12563283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W156887710","https://openalex.org/W1480481839","https://openalex.org/W1531455680","https://openalex.org/W1549300769","https://openalex.org/W1621116580","https://openalex.org/W1640809349","https://openalex.org/W1664200544","https://openalex.org/W1682432066","https://openalex.org/W1838211711","https://openalex.org/W1847746464","https://openalex.org/W1860002328","https://openalex.org/W1964303842","https://openalex.org/W1964922357","https://openalex.org/W1965414505","https://openalex.org/W1965626537","https://openalex.org/W1966477065","https://openalex.org/W1968995022","https://openalex.org/W1969985618","https://openalex.org/W1971542322","https://openalex.org/W1971874410","https://openalex.org/W1972744357","https://openalex.org/W1973920989","https://openalex.org/W1973941257","https://openalex.org/W1975870401","https://openalex.org/W1980756467","https://openalex.org/W1981453391","https://openalex.org/W1984937053","https://openalex.org/W1984961004","https://openalex.org/W1986331805","https://openalex.org/W1986335003","https://openalex.org/W1986776658","https://openalex.org/W1988514864","https://openalex.org/W1988610338","https://openalex.org/W1989067618","https://openalex.org/W1989531381","https://openalex.org/W1989776859","https://openalex.org/W1990809315","https://openalex.org/W1992116689","https://openalex.org/W1992958536","https://openalex.org/W1993984710","https://openalex.org/W1994667935","https://openalex.org/W1996235939","https://openalex.org/W1996285538","https://openalex.org/W1996955278","https://openalex.org/W1998463685","https://openalex.org/W2001495408","https://openalex.org/W2002499460","https://openalex.org/W2002561586","https://openalex.org/W2003702955","https://openalex.org/W2005790492","https://openalex.org/W2011467935","https://openalex.org/W2013448879","https://openalex.org/W2014292015","https://openalex.org/W2015963352","https://openalex.org/W2017280503","https://openalex.org/W2017608248","https://openalex.org/W2017629598","https://openalex.org/W2018056485","https://openalex.org/W2019628762","https://openalex.org/W2023334159","https://openalex.org/W2023671624","https://openalex.org/W2027471981","https://openalex.org/W2031500517","https://openalex.org/W2031539073","https://openalex.org/W2034953057","https://openalex.org/W2037388654","https://openalex.org/W2039178959","https://openalex.org/W2039262215","https://openalex.org/W2042040860","https://openalex.org/W2042733698","https://openalex.org/W2047278319","https://openalex.org/W2049088920","https://openalex.org/W2049511526","https://openalex.org/W2051092834","https://openalex.org/W2051349792","https://openalex.org/W2052032833","https://openalex.org/W2053894101","https://openalex.org/W2055015343","https://openalex.org/W2057511865","https://openalex.org/W2058137702","https://openalex.org/W2058159881","https://openalex.org/W2060119702","https://openalex.org/W2060287150","https://openalex.org/W2060308781","https://openalex.org/W2061112647","https://openalex.org/W2061420115","https://openalex.org/W2067368984","https://openalex.org/W2071596004","https://openalex.org/W2072277814","https://openalex.org/W2074292769","https://openalex.org/W2074671627","https://openalex.org/W2074949244","https://openalex.org/W2079322881","https://openalex.org/W2080527859","https://openalex.org/W2081021664","https://openalex.org/W2082424919","https://openalex.org/W2083051733","https://openalex.org/W2083551870","https://openalex.org/W2087024027","https://openalex.org/W2087991407","https://openalex.org/W2088367343","https://openalex.org/W2091181468","https://openalex.org/W2092094801","https://openalex.org/W2094257584","https://openalex.org/W2094605937","https://openalex.org/W2095163399","https://openalex.org/W2102773142","https://openalex.org/W2106607972","https://openalex.org/W2108497122","https://openalex.org/W2112196515","https://openalex.org/W2112286822","https://openalex.org/W2113796246","https://openalex.org/W2113836851","https://openalex.org/W2114808045","https://openalex.org/W2116540282","https://openalex.org/W2122767334","https://openalex.org/W2123652062","https://openalex.org/W2128218766","https://openalex.org/W2130270464","https://openalex.org/W2140994013","https://openalex.org/W2152452311","https://openalex.org/W2156347069","https://openalex.org/W2157090929","https://openalex.org/W2164701017","https://openalex.org/W2165568690","https://openalex.org/W2167382671","https://openalex.org/W2170842984","https://openalex.org/W2191091382","https://openalex.org/W2255649089","https://openalex.org/W2257594985","https://openalex.org/W2323730096","https://openalex.org/W2414042622","https://openalex.org/W2414818666","https://openalex.org/W2477235922","https://openalex.org/W2497125243","https://openalex.org/W3013344680","https://openalex.org/W4250786658","https://openalex.org/W4302230037"],"related_works":["https://openalex.org/W2123035658","https://openalex.org/W175128892","https://openalex.org/W3023825757","https://openalex.org/W2067032924","https://openalex.org/W2981937068","https://openalex.org/W2041960301","https://openalex.org/W2118388838","https://openalex.org/W1544705343","https://openalex.org/W107032819","https://openalex.org/W1514751202"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":31},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":36},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":38},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":31},{"year":2017,"cited_by_count":36},{"year":2016,"cited_by_count":40},{"year":2015,"cited_by_count":39},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":56},{"year":2012,"cited_by_count":45}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}