{"id":"https://openalex.org/W2022565622","doi":"https://doi.org/10.1006/jmbi.1999.3285","title":"The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5","display_name":"The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2022565622","doi":"https://doi.org/10.1006/jmbi.1999.3285","mag":"2022565622","pmid":"https://pubmed.ncbi.nlm.nih.gov/10588902"},"language":"en","primary_location":{"id":"doi:10.1006/jmbi.1999.3285","doi":"https://doi.org/10.1006/jmbi.1999.3285","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jmbi.1999.3285","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022283699932850/pdf","source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0022283699932850/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112756627","display_name":"Peter L. Privalov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter L. Privalov","raw_affiliation_strings":["Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. privalov@jhu.edu","Department of Biology, Johns Hopkins University, Baltimore MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. privalov@jhu.edu","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biology, Johns Hopkins University, Baltimore MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063734176","display_name":"Ilian Jelesarov","orcid":"https://orcid.org/0000-0002-4143-3377","observed_orcids":["https://orcid.org/0000-0002-4143-3377"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilian Jelesarov","raw_affiliation_strings":["Department of Biology Johns Hopkins University, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology Johns Hopkins University, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108531634","display_name":"Christopher M. Read","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher M. Read","raw_affiliation_strings":["Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037782085","display_name":"Anatoly I. Dragan","orcid":"https://orcid.org/0000-0002-1679-8307","observed_orcids":["https://orcid.org/0000-0002-1679-8307"]},"institutions":[{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anatoly I. Dragan","raw_affiliation_strings":["Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophysics Laboratories, School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019581385","display_name":"Colyn Crane\u2010Robinson","orcid":"https://orcid.org/0000-0002-6853-5293","observed_orcids":["https://orcid.org/0000-0002-6853-5293"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colyn Crane-Robinson","raw_affiliation_strings":["Department of Biology Johns Hopkins University, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology Johns Hopkins University, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112756627"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":{"value":4730,"currency":"USD","value_usd":4730},"fwci":3.6958,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.94334026,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"294","issue":"4","first_page":"997","last_page":"1013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmg-box","display_name":"HMG box","score":0.8420000076293945},{"id":"https://openalex.org/keywords/minor-groove-binding","display_name":"minor groove binding","score":0.6880000233650208},{"id":"https://openalex.org/keywords/binding-enthalpy","display_name":"binding enthalpy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/binding-entropy","display_name":"binding entropy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/heat-capacity-change","display_name":"heat capacity change","score":0.6909999847412109},{"id":"https://openalex.org/keywords/counterion-release","display_name":"counterion release","score":0.8009999990463257},{"id":"https://openalex.org/keywords/binding-constant","display_name":"binding constant","score":0.5580000281333923},{"id":"https://openalex.org/keywords/temperature-dependent-binding","display_name":"temperature dependence of binding","score":0.7319999933242798},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.3059999942779541},{"id":"https://openalex.org/keywords/binding-free-energy","display_name":"binding free energy","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.9158775806427002},{"id":"https://openalex.org/C60205243","wikidata":"https://www.wikidata.org/wiki/Q179388","display_name":"Heat capacity","level":2,"score":0.7972960472106934},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7368751764297485},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.7051339149475098},{"id":"https://openalex.org/C202270520","wikidata":"https://www.wikidata.org/wiki/Q634314","display_name":"Calorimetry","level":2,"score":0.7012597322463989},{"id":"https://openalex.org/C3288061","wikidata":"https://www.wikidata.org/wiki/Q161064","display_name":"Enthalpy","level":2,"score":0.6357190608978271},{"id":"https://openalex.org/C146477669","wikidata":"https://www.wikidata.org/wiki/Q334631","display_name":"Gibbs free energy","level":2,"score":0.5937976837158203},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.5118107199668884},{"id":"https://openalex.org/C20976626","wikidata":"https://www.wikidata.org/wiki/Q12571883","display_name":"Endothermic process","level":3,"score":0.49360978603363037},{"id":"https://openalex.org/C45119746","wikidata":"https://www.wikidata.org/wiki/Q205949","display_name":"Exothermic reaction","level":2,"score":0.45029374957084656},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.4487449824810028},{"id":"https://openalex.org/C39353612","wikidata":"https://www.wikidata.org/wiki/Q5283759","display_name":"Atmospheric temperature range","level":2,"score":0.41965562105178833},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.39145025610923767},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.34944015741348267},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11224475502967834},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.07524862885475159},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055755","descriptor_name":"SOXD Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/jmbi.1999.3285","doi":"https://doi.org/10.1006/jmbi.1999.3285","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jmbi.1999.3285","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022283699932850/pdf","source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:10588902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10588902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1006/jmbi.1999.3285","doi":"https://doi.org/10.1006/jmbi.1999.3285","is_oa":true,"landing_page_url":"https://doi.org/10.1006/jmbi.1999.3285","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022283699932850/pdf","source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3810336858","display_name":"FORCES STABILIZING NATIVE PROTEIN STRUCTURES","funder_award_id":"R01GM048036","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022565622.pdf","grobid_xml":"https://content.openalex.org/works/W2022565622.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W28039676","https://openalex.org/W31788419","https://openalex.org/W129812222","https://openalex.org/W176210329","https://openalex.org/W187801720","https://openalex.org/W618112851","https://openalex.org/W1495475575","https://openalex.org/W1518002808","https://openalex.org/W1524706855","https://openalex.org/W1533569014","https://openalex.org/W1570696801","https://openalex.org/W1572030366","https://openalex.org/W1965127482","https://openalex.org/W1965398400","https://openalex.org/W1967191931","https://openalex.org/W1974197041","https://openalex.org/W1975938313","https://openalex.org/W1981482769","https://openalex.org/W1982967693","https://openalex.org/W1983678802","https://openalex.org/W1992043136","https://openalex.org/W1994706623","https://openalex.org/W2001857107","https://openalex.org/W2001898035","https://openalex.org/W2005367001","https://openalex.org/W2007434518","https://openalex.org/W2008172549","https://openalex.org/W2008846230","https://openalex.org/W2013562725","https://openalex.org/W2016233481","https://openalex.org/W2021010454","https://openalex.org/W2026598193","https://openalex.org/W2028847605","https://openalex.org/W2032864324","https://openalex.org/W2032897685","https://openalex.org/W2034543599","https://openalex.org/W2035797443","https://openalex.org/W2037122000","https://openalex.org/W2044791372","https://openalex.org/W2045694929","https://openalex.org/W2046278558","https://openalex.org/W2049307015","https://openalex.org/W2054448211","https://openalex.org/W2056192634","https://openalex.org/W2059992766","https://openalex.org/W2077368232","https://openalex.org/W2091755990","https://openalex.org/W2094825303","https://openalex.org/W2141171773","https://openalex.org/W2151226445","https://openalex.org/W2154863979","https://openalex.org/W2160293127","https://openalex.org/W2281810567","https://openalex.org/W2312733215","https://openalex.org/W2411963429","https://openalex.org/W6714901847"],"related_works":["https://openalex.org/W2008172549","https://openalex.org/W2077368232","https://openalex.org/W2078493408","https://openalex.org/W2157459448","https://openalex.org/W2013268783","https://openalex.org/W2091755990","https://openalex.org/W170478169","https://openalex.org/W1987693921","https://openalex.org/W7217327714","https://openalex.org/W2166454956"],"abstract_inverted_index":{"The":[0,328,359],"energetics":[1],"of":[2,37,45,78,81,107,125,138,162,169,180,194,209,223,238,240,256,268,270,298,310,312,332,340,346,357,362,379,381,394],"the":[3,12,34,42,46,56,79,135,142,149,159,163,166,177,181,195,199,205,210,215,236,241,245,251,263,271,277,306,325,336,353,376],"Sox-5":[4,170],"HMG":[5,39,167,274],"box":[6,40,168,275,388],"interaction":[7],"with":[8,41,52,232,276,292,391],"DNA":[9,182,279,341],"duplexes,":[10],"containing":[11],"recognition":[13],"sequence":[14,299],"AACAAT,":[15],"were":[16,290],"studied":[17],"by":[18,375],"fluorescence":[19],"spectroscopy,":[20],"isothermal":[21],"titration":[22,31],"calorimetry":[23,28],"(ITC)":[24],"and":[25,95,176,212,250,253,266,308,349,355,366],"differential":[26],"scanning":[27],"(DSC).":[29],"Fluorescence":[30],"showed":[32,87,156],"that":[33,134,157,193,233,305,386],"association":[35,82,143,257,269,311,389],"constant":[36],"this":[38,84],"duplexes":[43,183,280],"is":[44,59],"order":[47],"4x10(7)":[48],"M(-1),":[49],"increasing":[50],"somewhat":[51],"temperature":[53,85,151,160,221,286],"rise,":[54],"i.e.":[55,397],"Gibbs":[57,254],"energy":[58,255],"-40":[60],"kJ":[61,70,110,226],"mol(-1)":[62,71],"at":[63,72,259,352],"5":[64,260],"degrees":[65,74,93,261],"C,":[66,262],"decreasing":[67],"to":[68,172,335,368,372],"-48":[69],"32":[73],"C.":[75],"ITC":[76,126,164,200],"measurements":[77],"enthalpy":[80,252,265,307],"over":[83,148,158,283],"range":[86,161],"an":[88,96],"endothermic":[89],"effect":[90,98],"below":[91],"17":[92],"C":[94],"exothermic":[97],"above,":[99],"suggesting":[100],"a":[101,113,220,284],"heat":[102,129,136,175,178,188,206,247],"capacity":[103,130,189,207,248],"change":[104,147,249],"on":[105,235],"binding":[106,202,315,323,334],"about":[108,224],"-4":[109],"K(-1)":[111,227],"mol(-1),":[112,228],"value":[114],"twice":[115],"larger":[116],"than":[117,320],"expected":[118,360],"from":[119,192,344],"structural":[120],"considerations.":[121],"A":[122],"straightforward":[123],"interpretation":[124],"data":[127],"in":[128,141,229,324,399],"terms":[131],"assumes,":[132],"however,":[133],"capacities":[137,179],"all":[139],"participants":[140],"reaction":[144],"do":[145],"not":[146],"considered":[150],"range.":[152,287],"Our":[153],"previous":[154],"studies":[155],"experiments":[165],"starts":[171],"unfold,":[173],"absorbing":[174],"also":[184],"increase":[185],"significantly.":[186],"These":[187,288],"effects":[190],"differ":[191],"DNA/Sox-5":[196],"complex.":[197],"Correcting":[198],"measured":[201,258],"enthalpies":[203,217],"for":[204,294,321],"changes":[208],"components":[211],"complex":[213],"yielded":[214],"net":[216,264],"which":[218],"exhibit":[219],"dependence":[222],"-2":[225],"good":[230],"agreement":[231],"predicted":[234],"basis":[237],"dehydration":[239,345,363],"protein-DNA":[242],"interface.":[243],"Using":[244],"derived":[246],"entropy":[267,309,361,378],"fully":[272],"folded":[273],"target":[278],"was":[281,364],"determined":[282],"broad":[285],"functions":[289],"compared":[291],"those":[293],"other":[295],"known":[296],"cases":[297],"specific":[300],"DNA/protein":[301],"association.":[302],"It":[303],"appears":[304],"minor":[313,338],"groove":[314,339],"proteins":[316,322],"are":[317],"more":[318],"positive":[319],"major":[326],"groove.":[327],"observed":[329],"thermodynamic":[330],"characteristics":[331],"protein":[333],"A+T-rich":[337],"might":[342],"result":[343],"both":[347],"polar":[348],"non-polar":[350],"groups":[351],"interface":[354],"release":[356],"counterions.":[358],"calculated":[365],"found":[367],"be":[369,373],"too":[370],"large":[371],"compensated":[374],"negative":[377],"reduction":[380,398],"translational/rotational":[382],"freedom.":[383],"This":[384],"implies":[385],"DNA/HMG":[387],"proceeds":[390],"significant":[392],"decrease":[393],"conformational":[395,400],"entropy,":[396],"mobility.":[401]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}