{"id":"https://openalex.org/W2022550581","doi":"https://doi.org/10.1590/s0066-782x2012005000066","title":"Trimetazidina e resposta inflamat\u00f3ria em cirurgia de revasculariza\u00e7\u00e3o do mioc\u00e1rdio","display_name":"Trimetazidina e resposta inflamat\u00f3ria em cirurgia de revasculariza\u00e7\u00e3o do mioc\u00e1rdio","publication_year":2012,"publication_date":"2012-07-12","ids":{"openalex":"https://openalex.org/W2022550581","doi":"https://doi.org/10.1590/s0066-782x2012005000066","mag":"2022550581","pmid":"https://pubmed.ncbi.nlm.nih.gov/22790403"},"language":"pt","primary_location":{"id":"doi:10.1590/s0066-782x2012005000066","doi":"https://doi.org/10.1590/s0066-782x2012005000066","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0066-782x2012005000066","pdf_url":"https://www.scielo.br/j/abc/a/LZDdgRHHzJ7Tb5jdb93vvGJ/?lang=en&format=pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/abc/a/LZDdgRHHzJ7Tb5jdb93vvGJ/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112299073","display_name":"Gerez Fernandes Martins","orcid":"https://orcid.org/0000-0001-5831-609X","observed_orcids":["https://orcid.org/0000-0001-5831-609X"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gerez Fernandes Martins","raw_affiliation_strings":["Instituto de Cardiologia Aloysio de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. gerezm@cardiol.br","Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cardiologia Aloysio de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. gerezm@cardiol.br","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109998382","display_name":"Aristarco Gon\u00e7alves de Siqueira Filho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aristarco Gon\u00e7alves de Siqueira Filho","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011237274","display_name":"Jo\u00e3o Bosco de Figueiredo Santos","orcid":"https://orcid.org/0000-0001-9711-6808","observed_orcids":["https://orcid.org/0000-0001-9711-6808"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Bosco de Figueiredo Santos","raw_affiliation_strings":["Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005946479","display_name":"Claudio Roberto Cavalcanti Assun\u00e7\u00e3o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Claudio Roberto Cavalcanti Assun\u00e7\u00e3o","raw_affiliation_strings":["Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110039375","display_name":"Francisca Bottino Vieira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisca Bottino Vieira","raw_affiliation_strings":["Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","Rua Humait\u00e1 , 231, apto. 101 , Humait\u00e1. CEP 22261-000 , Rio de Janeiro , RJ - Brasil","Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Rua Humait\u00e1 , 231, apto. 101 , Humait\u00e1. CEP 22261-000 , Rio de Janeiro , RJ - Brasil","institution_ids":[]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078962511","display_name":"Alberto Valencia-Hip\u03cclito","orcid":"https://orcid.org/0000-0002-2733-9421","observed_orcids":["https://orcid.org/0000-0002-2733-9421"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alberto Val\u00eancia","raw_affiliation_strings":["Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027755016","display_name":"K\u00e1ttia Ger\u00fandio de Carvalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"K\u00e1ttia Ger\u00fancio de Carvalho","raw_affiliation_strings":["Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030323629","display_name":"Barbara Jessen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Barbara Jessen","raw_affiliation_strings":["Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Cardiologia Aloysio de Castro , Rio de Janeiro , RJ ; Universidade Federal do Rio de Janeiro , Rio de Janeiro , RJ - Brasil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil","institution_ids":["https://openalex.org/I122140584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I122140584"],"apc_list":null,"apc_paid":null,"fwci":0.6637,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.70310486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"99","issue":"2","first_page":"688","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trimetazidine","display_name":"trimetazidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8790000081062317},{"id":"https://openalex.org/keywords/extracorporeal-circulation","display_name":"extracorporeal circulation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.949999988079071},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9770923256874084},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7232273817062378},{"id":"https://openalex.org/C2994232697","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal circulation","level":2,"score":0.7112843990325928},{"id":"https://openalex.org/C2777927741","wikidata":"https://www.wikidata.org/wiki/Q674703","display_name":"Trimetazidine","level":2,"score":0.6631923913955688},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.552811324596405},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.5142673850059509},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4202791452407837},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39782828092575073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39566972851753235},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3848290741443634},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014292","descriptor_name":"Trimetazidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1590/s0066-782x2012005000066","doi":"https://doi.org/10.1590/s0066-782x2012005000066","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0066-782x2012005000066","pdf_url":"https://www.scielo.br/j/abc/a/LZDdgRHHzJ7Tb5jdb93vvGJ/?lang=en&format=pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},{"id":"pmid:22790403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22790403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos brasileiros de cardiologia","raw_type":"Journal Article"},{"id":"pmh:oai:scielo:S0066-782X2012001100002","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2012001100002","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia v.99 n.2 2012","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2518845","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2518845","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Cardiologia v.99 n.2 2012","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:0c45b20f6fee453ab9952bde048b7b28","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0c45b20f6fee453ab9952bde048b7b28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Cardiologia, Vol 99, Iss 2, Pp 688-696 (2012)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f97db03a9f464a6a917e4c3ccc43511f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f97db03a9f464a6a917e4c3ccc43511f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Cardiologia, Vol 99, Iss 2, Pp 688-696 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/s0066-782x2012005000066","doi":"https://doi.org/10.1590/s0066-782x2012005000066","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0066-782x2012005000066","pdf_url":"https://www.scielo.br/j/abc/a/LZDdgRHHzJ7Tb5jdb93vvGJ/?lang=en&format=pdf","source":{"id":"https://openalex.org/S67004851","display_name":"Arquivos Brasileiros de Cardiologia","issn_l":"0066-782X","issn":["0066-782X","1678-4170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","scielo"],"host_organization":"https://openalex.org/P4310312504","host_organization_name":"Sociedade Brasileira de Cardiologia (SBC)","host_organization_lineage":["https://openalex.org/P4310312504"],"host_organization_lineage_names":["Sociedade Brasileira de Cardiologia (SBC)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Cardiologia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022550581.pdf","grobid_xml":"https://content.openalex.org/works/W2022550581.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1241277991","https://openalex.org/W1546148272","https://openalex.org/W1966420083","https://openalex.org/W1970045575","https://openalex.org/W1970547968","https://openalex.org/W1972045410","https://openalex.org/W1989786238","https://openalex.org/W1999252358","https://openalex.org/W2006389304","https://openalex.org/W2010489167","https://openalex.org/W2016278577","https://openalex.org/W2023002615","https://openalex.org/W2034809025","https://openalex.org/W2034882335","https://openalex.org/W2039597310","https://openalex.org/W2049881307","https://openalex.org/W2053689033","https://openalex.org/W2057658004","https://openalex.org/W2069240175","https://openalex.org/W2070157667","https://openalex.org/W2071126815","https://openalex.org/W2072079908","https://openalex.org/W2074773055","https://openalex.org/W2078954508","https://openalex.org/W2080745848","https://openalex.org/W2098507195","https://openalex.org/W2108726504","https://openalex.org/W2109769967","https://openalex.org/W2132401137","https://openalex.org/W2167233342","https://openalex.org/W2774958894","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2311176695","https://openalex.org/W2002991332","https://openalex.org/W2372198895","https://openalex.org/W2350613532","https://openalex.org/W2403120089","https://openalex.org/W2359759210","https://openalex.org/W3031965703","https://openalex.org/W1966420083","https://openalex.org/W2958230634","https://openalex.org/W2343704889"],"abstract_inverted_index":{"BACKGROUND:":[0],"Organic":[1],"inflammatory":[2,22,48],"response":[3],"is":[4],"a":[5,34],"pathophysiological":[6],"mechanism":[7],"present":[8],"at":[9,91,112,203],"every":[10],"coronary":[11],"artery":[12],"bypass":[13],"grafting":[14],"with":[15,85,127,197],"extracorporeal":[16],"circulation":[17],"(CABG-ECC),":[18],"the":[19,41,47,52,72,113,124,131,170,184,192,200],"release":[20],"of":[21,26,43,115,133,172],"mediators":[23],"being":[24],"one":[25],"its":[27],"defense":[28],"mechanisms.":[29],"OBJECTIVE:":[30],"To":[31],"assess,":[32],"in":[33,54,71,123,191,199,219],"prospective":[35],"double-blind":[36],"randomized":[37],"and":[38,57,62,64,74,89,104,109,149,156,158,177,179],"placebo-controlled":[39],"study,":[40],"effects":[42],"trimetazidine":[44],"(Tmz)":[45],"on":[46,130,141],"response,":[49],"by":[50,107],"using":[51],"variation":[53],"interleukins":[55,155],"6":[56,186,218],"8,":[58,174],"TNF-\u03b1,":[59,175],"complements":[60],"C3":[61,176],"C5,":[63,178],"highly":[65],"sensitive":[66],"C-reactive":[67],"protein":[68],"(HS-CRP)":[69],"levels":[70,171,187],"pre-":[73],"post-operative":[75],"periods.":[76],"METHODS:":[77],"This":[78],"study":[79],"assessed":[80],"30":[81],"patients":[82,97,220],"undergoing":[83,221],"CABG-ECC":[84],"intermittent":[86],"hypothermic":[87],"cardioplegia,":[88],"having,":[90],"most,":[92],"mild":[93],"ventricular":[94],"dysfunction.":[95],"The":[96],"were":[98,119,188],"divided":[99],"into":[100],"two":[101],"groups":[102],"(placebo":[103],"Tmz),":[105],"stratified":[106],"echocardiography,":[108],"received":[110],"drug/placebo":[111],"dose":[114],"60":[116],"mg/day.":[117],"Measurements":[118],"taken":[120],"as":[121,195],"follows:":[122],"pre-operative":[125],"period":[126],"no":[128],"drug;":[129],"day":[132],"surgery,":[134,153,162],"corresponding":[135],"to":[136,138,211],"12":[137,148],"15":[139],"days":[140],"drug/placebo;":[142],"five":[143],"minutes":[144],"after":[145,152,161],"aortic":[146],"unclamping;":[147],"24":[150],"hours":[151,160],"for":[154,163,215],"complements;":[157],"48":[159],"HS-CRP.":[164],"RESULTS:":[165],"No":[166],"significant":[167],"difference":[168],"between":[169],"interleukin":[173,185,217],"HS-CRP":[180],"was":[181],"observed.":[182],"However,":[183],"significantly":[189],"lower":[190],"group":[193,202],"treated":[194],"compared":[196],"those":[198],"control":[201],"all":[204],"time":[205],"points":[206],"assessed.":[207],"CONCLUSION:":[208],"Trimetazidine":[209],"proved":[210],"be":[212],"effective":[213],"only":[214],"reducing":[216],"CABG.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}