{"id":"https://openalex.org/W2022545149","doi":"https://doi.org/10.1007/s12017-010-8138-2","title":"Functional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression and Disease Association","display_name":"Functional Genomics of Serotonin Receptor 2A (HTR2A): Interaction of Polymorphism, Methylation, Expression and Disease Association","publication_year":2010,"publication_date":"2010-10-13","ids":{"openalex":"https://openalex.org/W2022545149","doi":"https://doi.org/10.1007/s12017-010-8138-2","mag":"2022545149","pmid":"https://pubmed.ncbi.nlm.nih.gov/20941551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3044825"},"language":"en","primary_location":{"id":"doi:10.1007/s12017-010-8138-2","doi":"https://doi.org/10.1007/s12017-010-8138-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12017-010-8138-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12017-010-8138-2.pdf","source":{"id":"https://openalex.org/S45104802","display_name":"NeuroMolecular Medicine","issn_l":"1535-1084","issn":["1535-1084","1559-1174"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroMolecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12017-010-8138-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032130920","display_name":"Virginia R. Falkenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia R. Falkenberg","raw_affiliation_strings":["Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA 30333, USA","Division of Viral & Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta GA 30333, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA 30333, USA","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Division of Viral & Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta GA 30333, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054097366","display_name":"Brian M. Gurbaxani","orcid":"https://orcid.org/0000-0002-9731-7359","observed_orcids":["https://orcid.org/0000-0002-9731-7359"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian M. Gurbaxani","raw_affiliation_strings":["Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA","Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051624252","display_name":"Elizabeth R. Unger","orcid":"https://orcid.org/0000-0002-2925-5635","observed_orcids":["https://orcid.org/0000-0002-2925-5635"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R. Unger","raw_affiliation_strings":["Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA","Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111993184","display_name":"Mangalathu S. Rajeevan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mangalathu S. Rajeevan","raw_affiliation_strings":["Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA","Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA","institution_ids":["https://openalex.org/I1289490764"]},{"raw_affiliation_string":"Division of Viral and Rickettsial Diseases, Centers for Disease Control & Prevention, Atlanta, USA","institution_ids":["https://openalex.org/I1289490764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111993184"],"corresponding_institution_ids":["https://openalex.org/I1289490764"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.8053,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.84192505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"66","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.20399999618530273,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.09730000048875809,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/htr2a","display_name":"HTR2A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/chronic-fatigue-syndrome","display_name":"chronic fatigue syndrome","score":0.7120000123977661},{"id":"https://openalex.org/keywords/allele-specific-expression","display_name":"allele-specific expression","score":0.6669999957084656},{"id":"https://openalex.org/keywords/glucocorticoid-receptor-binding","display_name":"glucocorticoid receptor binding","score":0.8529999852180481},{"id":"https://openalex.org/keywords/sp1-binding","display_name":"Sp1 binding","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.7300000190734863},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5841819643974304},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5592086911201477},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5368016362190247},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.48208409547805786},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.44254356622695923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4294363856315613},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4271537661552429},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4229121208190918},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3460920453071594},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.320002943277359},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2736581563949585},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.209524005651474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19490689039230347},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18465015292167664},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1773395538330078},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1364840269088745},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.08473175764083862}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015673","descriptor_name":"Fatigue Syndrome, Chronic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1007/s12017-010-8138-2","doi":"https://doi.org/10.1007/s12017-010-8138-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12017-010-8138-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12017-010-8138-2.pdf","source":{"id":"https://openalex.org/S45104802","display_name":"NeuroMolecular Medicine","issn_l":"1535-1084","issn":["1535-1084","1559-1174"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroMolecular Medicine","raw_type":"journal-article"},{"id":"pmid:20941551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20941551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuromolecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3044825","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3044825/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuromolecular Med","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1816640","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1816640","pdf_url":"https://www.osti.gov/servlets/purl/1816640","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.293.2889","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.2889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/00/d4/Neuromolecular_Med_2011_Mar_13_13(1)_66-76.tar.gz","raw_type":"text"},{"id":"mag:2183560329","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/s12017-010-8138-2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/s12017-010-8138-2","doi":"https://doi.org/10.1007/s12017-010-8138-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12017-010-8138-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12017-010-8138-2.pdf","source":{"id":"https://openalex.org/S45104802","display_name":"NeuroMolecular Medicine","issn_l":"1535-1084","issn":["1535-1084","1559-1174"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroMolecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022545149.pdf","grobid_xml":"https://content.openalex.org/works/W2022545149.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W46266345","https://openalex.org/W1517511965","https://openalex.org/W1659444689","https://openalex.org/W1964471207","https://openalex.org/W1966051795","https://openalex.org/W1967844297","https://openalex.org/W1974002816","https://openalex.org/W1989573122","https://openalex.org/W1989741780","https://openalex.org/W1996292235","https://openalex.org/W2022452929","https://openalex.org/W2065628230","https://openalex.org/W2065754201","https://openalex.org/W2069799601","https://openalex.org/W2079763005","https://openalex.org/W2080450769","https://openalex.org/W2105194498","https://openalex.org/W2106308884","https://openalex.org/W2107763532","https://openalex.org/W2108819945","https://openalex.org/W2126230123","https://openalex.org/W2138445399","https://openalex.org/W2140425130","https://openalex.org/W2140428747","https://openalex.org/W2143162176","https://openalex.org/W2145759110","https://openalex.org/W2153550523","https://openalex.org/W2170165650","https://openalex.org/W2416184099"],"related_works":["https://openalex.org/W2183560329","https://openalex.org/W56460069","https://openalex.org/W2164963538","https://openalex.org/W2571471875","https://openalex.org/W2140425130","https://openalex.org/W2047958166","https://openalex.org/W2079763005","https://openalex.org/W2003640444","https://openalex.org/W2002560462","https://openalex.org/W2094670444"],"abstract_inverted_index":{"Serotonergic":[0],"neurotransmission":[1],"plays":[2],"a":[3,16,80,115,122,145,161,211],"key":[4],"role":[5],"in":[6,21,37,73,86,98,210,245],"the":[7,24,38,59,62,110,152,182,205,225],"pathophysiology":[8],"of":[9,15,23,27,40,61,112,154,207,228,231,234],"neuropsychiatric":[10],"illnesses.":[11],"The":[12],"functional":[13,50,239],"significance":[14],"promoter":[17,183,193],"polymorphism,":[18],"-1438G/A":[19],"(rs6311),":[20,64],"one":[22],"major":[25,232],"genes":[26,233],"this":[28,196],"system":[29],"(serotonin":[30],"receptor":[31,117],"2A,":[32],"HTR2A)":[33],"remains":[34],"poorly":[35],"understood":[36],"context":[39],"epigenetic":[41],"factors,":[42],"transcription":[43,93,189,209],"factors":[44,94],"and":[45,51,67,127,167,192,195,213,241],"endocrine":[46],"influences.":[47],"We":[48],"used":[49],"structural":[52],"equation":[53],"modeling":[54],"(SEM)":[55],"approaches":[56],"to":[57,70],"assess":[58],"contributions":[60],"polymorphism":[63,184],"DNA":[65],"methylation":[66,132,142],"clinical":[68],"variables":[69],"HTR2A":[71,83,176,208],"expression":[72,90],"chronic":[74],"fatigue":[75],"syndrome":[76],"(CFS)":[77],"subjects":[78],"from":[79],"population-based":[81],"study.":[82],"was":[84,138],"up-regulated":[85],"CFS":[87],"through":[88],"allele-specific":[89],"modulated":[91],"by":[92,109,237],"at":[95,105,124,130,136,143,156],"critical":[96],"sites":[97],"its":[99],"promoter:":[100],"an":[101,199,221,246],"E47":[102,166],"binding":[103,119,129,169,191],"site":[104,120,133,147],"position":[106,125,157],"-1,438,":[107],"(created":[108],"A-allele":[111],"rs6311":[113,155],"polymorphism),":[114],"glucocorticoid":[116],"(GR)":[118],"encompassing":[121],"CpG":[123,131,146],"-1,420,":[126],"Sp1":[128],"-1,224.":[134],"Methylation":[135],"-1,420":[137],"strongly":[139],"correlated":[140],"with":[141,172,198],"-1,439,":[144],"that":[148,181],"is":[149,250],"dependent":[150],"upon":[151],"G-allele":[153],"-1,438.":[158],"SEM":[159,242],"revealed":[160],"strong":[162],"negative":[163],"interaction":[164],"between":[165],"GR":[168],"(in":[170],"conjunction":[171],"cortisol":[173],"level)":[174],"on":[175],"expression.":[177],"This":[178,216],"study":[179,217,248],"suggests":[180],"(rs6311)":[185],"can":[186,203,218],"affect":[187],"both":[188],"factor":[190],"methylation,":[194],"along":[197],"individual's":[200],"stress":[201],"response":[202],"impact":[204],"rate":[206],"genotype":[212],"methylation-dependent":[214],"manner.":[215],"serve":[219],"as":[220],"example":[222],"for":[223],"deciphering":[224],"molecular":[226],"determinants":[227],"transcriptional":[229],"regulation":[230],"medical":[235],"importance":[236],"integrating":[238],"genomics":[240],"approaches.":[243],"Confirmation":[244],"independent":[247],"population":[249],"required.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}