{"id":"https://openalex.org/W2022449923","doi":"https://doi.org/10.1359/jbmr.060808","title":"Robust and Comprehensive Analysis of 20 Osteoporosis Candidate Genes by Very High-Density Single-Nucleotide Polymorphism Screen Among 405 White Nuclear Families Identified Significant Association and Gene\u2013Gene Interaction","display_name":"Robust and Comprehensive Analysis of 20 Osteoporosis Candidate Genes by Very High-Density Single-Nucleotide Polymorphism Screen Among 405 White Nuclear Families Identified Significant Association and Gene\u2013Gene Interaction","publication_year":2006,"publication_date":"2006-09-29","ids":{"openalex":"https://openalex.org/W2022449923","doi":"https://doi.org/10.1359/jbmr.060808","mag":"2022449923","pmid":"https://pubmed.ncbi.nlm.nih.gov/17002564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1829486"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.060808","doi":"https://doi.org/10.1359/jbmr.060808","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.060808","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1829486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110132148","display_name":"Dong-Hai Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Hai Xiong","raw_affiliation_strings":["Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013518217","display_name":"Hui Shen","orcid":"https://orcid.org/0000-0003-0335-6064","observed_orcids":["https://orcid.org/0000-0003-0335-6064","https://orcid.org/0009-0007-1039-8955"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Shen","raw_affiliation_strings":["Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri\u2013Kansas City, Kansas City, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri\u2013Kansas City, Kansas City, Missouri, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113534058","display_name":"Lan-Juan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan-Juan Zhao","raw_affiliation_strings":["Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059561825","display_name":"Peng Xiao","orcid":"https://orcid.org/0000-0003-0075-581X","observed_orcids":["https://orcid.org/0000-0003-0075-581X"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Xiao","raw_affiliation_strings":["Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078356696","display_name":"Tie\u2010Lin Yang","orcid":"https://orcid.org/0000-0001-7062-3025","observed_orcids":["https://orcid.org/0000-0001-7062-3025"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tie-Lin Yang","raw_affiliation_strings":["The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059564497","display_name":"Yan Guo","orcid":"https://orcid.org/0000-0002-7364-2392","observed_orcids":["https://orcid.org/0000-0002-7364-2392","https://orcid.org/0000-0002-2908-4231"]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Guo","raw_affiliation_strings":["Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China","The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I173759888"]},{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695506","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-5750-6980","observed_orcids":["https://orcid.org/0000-0002-5750-6980","https://orcid.org/0000-0002-5974-1589","https://orcid.org/0000-0001-6280-0191"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100845057","display_name":"Yan-Fang Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Fang Guo","raw_affiliation_strings":["Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China","The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I173759888"]},{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007234866","display_name":"Yong\u2010Jun Liu","orcid":"https://orcid.org/0000-0002-1728-480X","observed_orcids":["https://orcid.org/0000-0002-1728-480X"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong-Jun Liu","raw_affiliation_strings":["Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052478195","display_name":"Robert R. Recker","orcid":"https://orcid.org/0000-0002-8774-1404","observed_orcids":["https://orcid.org/0000-0002-8774-1404"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R Recker","raw_affiliation_strings":["Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024194480","display_name":"Hong\u2010Wen Deng","orcid":"https://orcid.org/0000-0002-0387-8818","observed_orcids":["https://orcid.org/0000-0002-0387-8818","https://orcid.org/0000-0003-1933-7095"]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Hong-Wen Deng","raw_affiliation_strings":["Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri\u2013Kansas City, Kansas City, Missouri, USA","Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China","The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri\u2013Kansas City, Kansas City, Missouri, USA","institution_ids":["https://openalex.org/I75421653"]},{"raw_affiliation_string":"Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I173759888"]},{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China","institution_ids":["https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024194480"],"corresponding_institution_ids":["https://openalex.org/I173759888","https://openalex.org/I75421653","https://openalex.org/I87445476"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":13.5762,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.99131211,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"11","first_page":"1678","last_page":"1695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.09260000288486481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/family-based-association","display_name":"family-based association","score":0.6570000052452087},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.9819999933242798},{"id":"https://openalex.org/keywords/rank","display_name":"RANK","score":0.49399998784065247},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cyp17","display_name":"CYP17","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lrp5","display_name":"LRP5","score":0.847000002861023},{"id":"https://openalex.org/keywords/dbp","display_name":"DBP","score":0.722000002861023},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tnfr2","display_name":"TNFR2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/galactic-cosmic-rays","display_name":"galactic cosmic rays","score":0.7760000228881836},{"id":"https://openalex.org/keywords/esr2","display_name":"ESR2","score":0.996999979019165},{"id":"https://openalex.org/keywords/sex-stratified-analysis","display_name":"sex-stratified analysis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ultradistal-radius","display_name":"ultradistal radius","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8298588991165161},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6648291349411011},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6300062537193298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.587878406047821},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5741868019104004},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.48307326436042786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47138816118240356},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.47088250517845154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4567417502403259},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.4357031583786011},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4254688620567322},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3471672236919403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.322573721408844},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.24383914470672607},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22563698887825012},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16314992308616638}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1359/jbmr.060808","doi":"https://doi.org/10.1359/jbmr.060808","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.060808","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:17002564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17002564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1829486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1829486","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Bone Miner Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1829486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1829486","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Bone Miner Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2150513565","display_name":"GENETIC LINKAGE TO LOW PEAK BONE MASS","funder_award_id":"R01AR045349","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G319540772","display_name":null,"funder_award_id":"R01 GM 60402-01A1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G427003618","display_name":null,"funder_award_id":"R01-AR-45349-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5164333802","display_name":"Robust and Powerful Test of Candidate Genes to Bone Mass","funder_award_id":"R01AR050496","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6064384742","display_name":"CHARACTERIZATION OF DELETERIOUS GENOMIC MUTATIONS","funder_award_id":"R01GM060402","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G749568872","display_name":"Genetic Basis of Osteoporotic Fractures and Bone Mass","funder_award_id":"K01AR002170","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G956266236","display_name":null,"funder_award_id":"K01 AR02170-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320309641","display_name":"Creighton University","ror":"https://ror.org/05wf30g94"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322195","display_name":"Huo Yingdong Education Foundation","ror":"https://ror.org/05w1m1q56"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W128384236","https://openalex.org/W1964091097","https://openalex.org/W1968426968","https://openalex.org/W1977945634","https://openalex.org/W1978146975","https://openalex.org/W2001930576","https://openalex.org/W2002604694","https://openalex.org/W2010061045","https://openalex.org/W2021134103","https://openalex.org/W2028225768","https://openalex.org/W2030705868","https://openalex.org/W2049352378","https://openalex.org/W2050691335","https://openalex.org/W2052393782","https://openalex.org/W2052930003","https://openalex.org/W2064803580","https://openalex.org/W2066326568","https://openalex.org/W2066813035","https://openalex.org/W2072038834","https://openalex.org/W2072203652","https://openalex.org/W2078070625","https://openalex.org/W2078870313","https://openalex.org/W2083413750","https://openalex.org/W2085266575","https://openalex.org/W2088657877","https://openalex.org/W2090999990","https://openalex.org/W2092856704","https://openalex.org/W2095483721","https://openalex.org/W2096551200","https://openalex.org/W2097237683","https://openalex.org/W2098611654","https://openalex.org/W2105306382","https://openalex.org/W2108903310","https://openalex.org/W2109572473","https://openalex.org/W2118578196","https://openalex.org/W2122893558","https://openalex.org/W2123774216","https://openalex.org/W2126561288","https://openalex.org/W2130318116","https://openalex.org/W2133389919","https://openalex.org/W2139587812","https://openalex.org/W2142198096","https://openalex.org/W2143719721","https://openalex.org/W2152664025","https://openalex.org/W2154572047","https://openalex.org/W2155635136","https://openalex.org/W2157020561","https://openalex.org/W2162530578","https://openalex.org/W2168766899","https://openalex.org/W2315295323"],"related_works":["https://openalex.org/W2131295941","https://openalex.org/W2139680032","https://openalex.org/W2587785064","https://openalex.org/W2031611890","https://openalex.org/W7098572172","https://openalex.org/W2020955666","https://openalex.org/W7100990139","https://openalex.org/W2067641079","https://openalex.org/W2512874803","https://openalex.org/W2072853202"],"abstract_inverted_index":{"UNLABELLED:":[0],"Many":[1],"\"novel\"":[2],"osteoporosis":[3,45,63,82,292,311],"candidate":[4,64,293],"genes":[5,25,46,65,163,187,200,294],"have":[6],"been":[7],"proposed":[8,299],"in":[9,19,32,253,300],"recent":[10,301],"years.":[11],"To":[12],"advance":[13],"our":[14],"knowledge":[15],"of":[16,29,43,50,60,118,249,291],"their":[17],"roles":[18],"osteoporosis,":[20],"we":[21,267],"screened":[22],"20":[23,61,126],"such":[24,148],"using":[26,66,145],"a":[27,33,271],"set":[28],"high-density":[30],"SNPs":[31],"large":[34],"family-based":[35,57,136],"study.":[36],"Our":[37,286],"efforts":[38],"led":[39],"to":[40],"the":[41,48,73,79,125,225,232,250,254,289,297,305],"prioritization":[42,290],"those":[44,219],"and":[47,78,92,112,134,140,153,167,191,198,204,218,228,269,278,303],"detection":[49],"gene-gene":[51,142,273,307],"interactions.":[52],"INTRODUCTION:":[53],"We":[54,128,160],"performed":[55,141],"large-scale":[56],"association":[58,130,137],"analyses":[59,131,144,244],"novel":[62],"277":[67],"single":[68],"nucleotide":[69],"polymorphisms":[70],"(SNPs)":[71],"for":[72,195,208,280],"quantitative":[74],"trait":[75,81],"BMD":[76,217],"variation":[77],"qualitative":[80],"(OP)":[83],"at":[84,224],"three":[85],"clinically":[86],"important":[87],"skeletal":[88],"sites:":[89],"spine,":[90,226],"hip,":[91,227],"ultradistal":[93],"radius":[94],"(UD).":[95],"MATERIALS":[96],"AND":[97,158],"METHODS:":[98],"One":[99],"thousand":[100],"eight":[101],"hundred":[102],"seventy-three":[103],"subjects":[104],"from":[105,295],"405":[106],"white":[107],"nuclear":[108],"families":[109],"were":[110,257],"genotyped":[111],"analyzed":[113],"with":[114,183,215,222],"an":[115],"average":[116],"density":[117],"one":[119],"SNP":[120],"per":[121],"4":[122],"kb":[123],"across":[124],"genes.":[127],"conducted":[129],"by":[132,259],"SNP-":[133],"haplotype-based":[135],"test":[138],"(FBAT)":[139],"interaction":[143,274,308],"multianalytic":[146],"approaches":[147],"as":[149],"multifactor-dimensionality":[150],"reduction":[151],"(MDR)":[152],"conditional":[154],"logistic":[155],"regression.":[156],"RESULTS":[157],"CONCLUSIONS:":[159],"detected":[161],"four":[162,186,199],"(DBP,":[164],"LRP5,":[165],"CYP17,":[166],"RANK)":[168],"that":[169,247],"showed":[170,246],"highly":[171,193,206],"suggestive":[172,194,207],"associations":[173,212,252],"(10,000-permutation":[174],"derived":[175],"empirical":[176],"global":[177,237],"p":[178,238],"<":[179,239],"or":[180,240,262],"=":[181,241],"0.01)":[182],"spine":[184],"BMD/OP;":[185,197],"(CYP19,":[188,201],"RANK,":[189,203],"RANKL,":[190],"CYP17)":[192],"hip":[196],"BMP2,":[202],"TNFR2)":[205],"UD":[209,216,229],"BMD/OP.":[210],"The":[211],"between":[213,220],"BMP2":[214],"RANK":[221],"OP":[223],"also":[230],"met":[231],"experiment-wide":[233],"stringent":[234],"criterion":[235],"(empirical":[236],"0.0007).":[242],"Sex-stratified":[243],"further":[245],"some":[248],"significant":[251,306],"total":[255],"sample":[256],"driven":[258],"either":[260],"male":[261],"female":[263],"subjects.":[264],"In":[265],"addition,":[266],"identified":[268],"validated":[270],"two-locus":[272],"model":[275],"involving":[276],"GCR":[277],"ESR2,":[279],"which":[281],"prior":[282],"biological":[283],"evidence":[284],"exists.":[285],"results":[287],"suggested":[288],"among":[296],"many":[298],"years":[302],"revealed":[304],"effects":[309],"influencing":[310],"risk.":[312]},"counts_by_year":[{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}